FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2615753090> ?p ?o ?g. }

• W2615753090 endingPage "4116" @default.
• W2615753090 startingPage "4111" @default.
• W2615753090 abstract "Rheumatoid Arthritis (RA) is a chronic autoimmune disease characterized by the inflammatory synovitis and the destructive cartilage and bone. Triptolide is a biologically active component purified from the Chinese herbal plant Tripterygium wilfordii Hook F (TWHF), which has presented benefits for the treatment of RA. In the current study, we investigated therapeutic effects of Triptolide in collageninduced rheumatoid arthritis rat model. Administration of Triptolide (30 μg/kg) was used to treat Collagen-Induced Arthritis (CIA) rat model by the subcutaneous injection of bovine type II collagen. Our data demonstrated the triptolide treatment significantly reduced inflammatory cytokines including IL-1β, TNF-α, IL-17 and IL-8 in serum in experimental rats. Results demonstrated that triptolide treatment reduced the expression of angiogenic activators Vascular Endothelial Growth Factor (VEGF), Toll-like receptor 2 (Tie2), Angiogenin-1 (Ang-1) and Angiogenin-2 (Ang-2) in synovial cells in experimental rats. Potential mechanism analyses triptolide treatment inhibited expression levels of receptor activator of NF-κB (RANK) ligand (RANKL), which further suppressed RANKL-induced expression and phosphorylation of ERK and AKT at protein levels. Histological analysis showed that triptolide treatment decreased immune cell infiltration and suppressed bone destruction that contributed to attenuation of arthritis severity in CIA rats. In conclusion, these results indicate that triptolide treatment not only inhibits inflammatory cytokines, but also possess anti-angiogenic effect in RA both in vivo and in vitro experiments through down-regulation of RANKL-mediated ERK/AKT signalling pathway, which contributes to understand molecular mechanism mediated by triptolide in the progression of RA." @default.
• W2615753090 created "2017-05-26" @default.
• W2615753090 creator A5021384155 @default.
• W2615753090 creator A5045926855 @default.
• W2615753090 creator A5048297609 @default.
• W2615753090 creator A5052304130 @default.
• W2615753090 creator A5056957683 @default.
• W2615753090 date "2017-01-01" @default.
• W2615753090 modified "2023-09-22" @default.
• W2615753090 title "Triptolide protects bone against destruction by targeting RANKL-mediated ERK/AKT signalling pathway in the collagen-induced rheumatoid arthritis" @default.
• W2615753090 cites W1129039978 @default.
• W2615753090 cites W1516626166 @default.
• W2615753090 cites W1761237057 @default.
• W2615753090 cites W1874085523 @default.
• W2615753090 cites W1886771579 @default.
• W2615753090 cites W1964107683 @default.
• W2615753090 cites W1972490124 @default.
• W2615753090 cites W1995490215 @default.
• W2615753090 cites W1996497504 @default.
• W2615753090 cites W2003747141 @default.
• W2615753090 cites W2010373560 @default.
• W2615753090 cites W2029878336 @default.
• W2615753090 cites W2046340040 @default.
• W2615753090 cites W2047563709 @default.
• W2615753090 cites W2082562728 @default.
• W2615753090 cites W2086635018 @default.
• W2615753090 cites W2090978105 @default.
• W2615753090 cites W2091055562 @default.
• W2615753090 cites W2111214871 @default.
• W2615753090 cites W2172338503 @default.
• W2615753090 cites W21878275 @default.
• W2615753090 cites W2216912148 @default.
• W2615753090 cites W2293561363 @default.
• W2615753090 cites W2333716667 @default.
• W2615753090 cites W2341257746 @default.
• W2615753090 cites W2390845717 @default.
• W2615753090 cites W2406719905 @default.
• W2615753090 cites W2413887177 @default.
• W2615753090 cites W2414495720 @default.
• W2615753090 cites W2415147199 @default.
• W2615753090 cites W2418187819 @default.
• W2615753090 cites W2539870148 @default.
• W2615753090 cites W2548614058 @default.
• W2615753090 cites W2615951221 @default.
• W2615753090 cites W2619420016 @default.
• W2615753090 hasPublicationYear "2017" @default.
• W2615753090 type Work @default.
• W2615753090 sameAs 2615753090 @default.
• W2615753090 citedByCount "0" @default.
• W2615753090 crossrefType "journal-article" @default.
• W2615753090 hasAuthorship W2615753090A5021384155 @default.
• W2615753090 hasAuthorship W2615753090A5045926855 @default.
• W2615753090 hasAuthorship W2615753090A5048297609 @default.
• W2615753090 hasAuthorship W2615753090A5052304130 @default.
• W2615753090 hasAuthorship W2615753090A5056957683 @default.
• W2615753090 hasConcept C126322002 @default.
• W2615753090 hasConcept C142724271 @default.
• W2615753090 hasConcept C164027704 @default.
• W2615753090 hasConcept C170493617 @default.
• W2615753090 hasConcept C185592680 @default.
• W2615753090 hasConcept C190283241 @default.
• W2615753090 hasConcept C203014093 @default.
• W2615753090 hasConcept C204787440 @default.
• W2615753090 hasConcept C2776914184 @default.
• W2615753090 hasConcept C2777077863 @default.
• W2615753090 hasConcept C2777575956 @default.
• W2615753090 hasConcept C2779428903 @default.
• W2615753090 hasConcept C2780695664 @default.
• W2615753090 hasConcept C2781164371 @default.
• W2615753090 hasConcept C502942594 @default.
• W2615753090 hasConcept C55493867 @default.
• W2615753090 hasConcept C57074206 @default.
• W2615753090 hasConcept C62478195 @default.
• W2615753090 hasConcept C71924100 @default.
• W2615753090 hasConcept C75217442 @default.
• W2615753090 hasConcept C88045685 @default.
• W2615753090 hasConcept C98274493 @default.
• W2615753090 hasConceptScore W2615753090C126322002 @default.
• W2615753090 hasConceptScore W2615753090C142724271 @default.
• W2615753090 hasConceptScore W2615753090C164027704 @default.
• W2615753090 hasConceptScore W2615753090C170493617 @default.
• W2615753090 hasConceptScore W2615753090C185592680 @default.
• W2615753090 hasConceptScore W2615753090C190283241 @default.
• W2615753090 hasConceptScore W2615753090C203014093 @default.
• W2615753090 hasConceptScore W2615753090C204787440 @default.
• W2615753090 hasConceptScore W2615753090C2776914184 @default.
• W2615753090 hasConceptScore W2615753090C2777077863 @default.
• W2615753090 hasConceptScore W2615753090C2777575956 @default.
• W2615753090 hasConceptScore W2615753090C2779428903 @default.
• W2615753090 hasConceptScore W2615753090C2780695664 @default.
• W2615753090 hasConceptScore W2615753090C2781164371 @default.
• W2615753090 hasConceptScore W2615753090C502942594 @default.
• W2615753090 hasConceptScore W2615753090C55493867 @default.
• W2615753090 hasConceptScore W2615753090C57074206 @default.
• W2615753090 hasConceptScore W2615753090C62478195 @default.
• W2615753090 hasConceptScore W2615753090C71924100 @default.
• W2615753090 hasConceptScore W2615753090C75217442 @default.
• W2615753090 hasConceptScore W2615753090C88045685 @default.

• next