Matches in SemOpenAlex for { <https://semopenalex.org/work/W2615885639> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2615885639 endingPage "483" @default.
- W2615885639 startingPage "477" @default.
- W2615885639 abstract "Polysaccharides extracted from medicinal plants possess multiple functions. However, the inhibitory capacity of polysaccharides on the metastasis of breast cancer remains unclear. In the present study, we investigated the inhibitory activity of Aconitum coreanum polysaccharide (ACP1) and its sulphated derivative ACP1-s on migratory behaviour of human breast cancer cells MDA-MB-435s and evaluated the underlying molecular mechanism. The data from Transwell assay indicated that ACP1 and ACP1-s caused a significant inhibition of MDA-MB-435s cell migration in vitro. ACP1 and ACP1-s significantly impaired MDA-MB-435s cell migratory behaviour, and the accumulated distance and average velocity of ACP1- and ACP1-s-treated cells were reduced markedly. We also found ACP1 and ACP1-s treatment could affect dynamic remodeling of actin cytoskeleton, and suppress phosphorylation and activation of signalling molecules, attributing to anti-metastatic role of ACP1 and ACP1-s. These findings reveal a novel therapeutic potential of A. coreanum polysaccharide and its sulphated derivative for breast cancer metastasis." @default.
- W2615885639 created "2017-05-26" @default.
- W2615885639 creator A5000394931 @default.
- W2615885639 creator A5001553975 @default.
- W2615885639 creator A5032726210 @default.
- W2615885639 creator A5042080721 @default.
- W2615885639 creator A5042431714 @default.
- W2615885639 date "2017-10-01" @default.
- W2615885639 modified "2023-09-26" @default.
- W2615885639 title "Effect of Aconitum coreanum polysaccharide and its sulphated derivative on the migration of human breast cancer MDA-MB-435s cell" @default.
- W2615885639 cites W1271389891 @default.
- W2615885639 cites W1981573832 @default.
- W2615885639 cites W1992978098 @default.
- W2615885639 cites W2001473917 @default.
- W2615885639 cites W2040512792 @default.
- W2615885639 cites W2042264070 @default.
- W2615885639 cites W2046307256 @default.
- W2615885639 cites W2057007315 @default.
- W2615885639 cites W2080145523 @default.
- W2615885639 cites W2091981858 @default.
- W2615885639 cites W2096934785 @default.
- W2615885639 cites W2105064482 @default.
- W2615885639 cites W2117692326 @default.
- W2615885639 cites W2146473598 @default.
- W2615885639 cites W2148559158 @default.
- W2615885639 cites W2153774146 @default.
- W2615885639 cites W2158731289 @default.
- W2615885639 cites W2165200432 @default.
- W2615885639 cites W2170825753 @default.
- W2615885639 cites W2215841079 @default.
- W2615885639 cites W2284798206 @default.
- W2615885639 cites W2333884632 @default.
- W2615885639 cites W2402636472 @default.
- W2615885639 doi "https://doi.org/10.1016/j.ijbiomac.2017.05.084" @default.
- W2615885639 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28527995" @default.
- W2615885639 hasPublicationYear "2017" @default.
- W2615885639 type Work @default.
- W2615885639 sameAs 2615885639 @default.
- W2615885639 citedByCount "17" @default.
- W2615885639 countsByYear W26158856392018 @default.
- W2615885639 countsByYear W26158856392019 @default.
- W2615885639 countsByYear W26158856392020 @default.
- W2615885639 countsByYear W26158856392021 @default.
- W2615885639 countsByYear W26158856392022 @default.
- W2615885639 countsByYear W26158856392023 @default.
- W2615885639 crossrefType "journal-article" @default.
- W2615885639 hasAuthorship W2615885639A5000394931 @default.
- W2615885639 hasAuthorship W2615885639A5001553975 @default.
- W2615885639 hasAuthorship W2615885639A5032726210 @default.
- W2615885639 hasAuthorship W2615885639A5042080721 @default.
- W2615885639 hasAuthorship W2615885639A5042431714 @default.
- W2615885639 hasBestOaLocation W26158856391 @default.
- W2615885639 hasConcept C100817775 @default.
- W2615885639 hasConcept C121608353 @default.
- W2615885639 hasConcept C137738243 @default.
- W2615885639 hasConcept C1491633281 @default.
- W2615885639 hasConcept C185592680 @default.
- W2615885639 hasConcept C202751555 @default.
- W2615885639 hasConcept C54355233 @default.
- W2615885639 hasConcept C55493867 @default.
- W2615885639 hasConcept C86803240 @default.
- W2615885639 hasConcept C96232424 @default.
- W2615885639 hasConceptScore W2615885639C100817775 @default.
- W2615885639 hasConceptScore W2615885639C121608353 @default.
- W2615885639 hasConceptScore W2615885639C137738243 @default.
- W2615885639 hasConceptScore W2615885639C1491633281 @default.
- W2615885639 hasConceptScore W2615885639C185592680 @default.
- W2615885639 hasConceptScore W2615885639C202751555 @default.
- W2615885639 hasConceptScore W2615885639C54355233 @default.
- W2615885639 hasConceptScore W2615885639C55493867 @default.
- W2615885639 hasConceptScore W2615885639C86803240 @default.
- W2615885639 hasConceptScore W2615885639C96232424 @default.
- W2615885639 hasFunder F4320321001 @default.
- W2615885639 hasLocation W26158856391 @default.
- W2615885639 hasLocation W26158856392 @default.
- W2615885639 hasOpenAccess W2615885639 @default.
- W2615885639 hasPrimaryLocation W26158856391 @default.
- W2615885639 hasRelatedWork W1971979825 @default.
- W2615885639 hasRelatedWork W1975636936 @default.
- W2615885639 hasRelatedWork W2068594338 @default.
- W2615885639 hasRelatedWork W2100592123 @default.
- W2615885639 hasRelatedWork W2351813201 @default.
- W2615885639 hasRelatedWork W2441983839 @default.
- W2615885639 hasRelatedWork W2533232420 @default.
- W2615885639 hasRelatedWork W3209699046 @default.
- W2615885639 hasRelatedWork W4205097258 @default.
- W2615885639 hasRelatedWork W4306385347 @default.
- W2615885639 hasVolume "103" @default.
- W2615885639 isParatext "false" @default.
- W2615885639 isRetracted "false" @default.
- W2615885639 magId "2615885639" @default.
- W2615885639 workType "article" @default.