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- W2616095402 abstract "Ribosome frameshifting during translation of bacterial dnaX can proceed via different routes, generating a variety of distinct polypeptides. Using kinetic experiments, we show that –1 frameshifting predominantly occurs during translocation of two tRNAs bound to the slippery sequence codons. This pathway depends on a stem-loop mRNA structure downstream of the slippery sequence and operates when aminoacyl-tRNAs are abundant. However, when aminoacyl-tRNAs are in short supply, the ribosome switches to an alternative frameshifting pathway that is independent of a stem-loop. Ribosome stalling at a vacant 0-frame A-site codon results in slippage of the P-site peptidyl-tRNA, allowing for –1-frame decoding. When the –1-frame aminoacyl-tRNA is lacking, the ribosomes switch into –2 frame. Quantitative mass spectrometry shows that the –2-frame product is synthesized in vivo. We suggest that switching between frameshifting routes may enrich gene expression at conditions of aminoacyl-tRNA limitation." @default.
- W2616095402 created "2017-05-26" @default.
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- W2616095402 date "2017-05-01" @default.
- W2616095402 modified "2023-10-14" @default.
- W2616095402 title "Conditional Switch between Frameshifting Regimes upon Translation of dnaX mRNA" @default.
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- W2616095402 doi "https://doi.org/10.1016/j.molcel.2017.04.023" @default.
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