Matches in SemOpenAlex for { <https://semopenalex.org/work/W2616097232> ?p ?o ?g. }
- W2616097232 endingPage "724" @default.
- W2616097232 startingPage "724" @default.
- W2616097232 abstract "<ns4:p>Nucleoside triphosphate (NTP)s, like ATP (adenosine 5’-triphosphate) and GTP (guanosine 5’-triphosphate), have long been considered sufficiently concentrated and diffusible to fuel all cellular ATPases (adenosine triphosphatases) and GTPases (guanosine triphosphatases) in an energetically healthy cell without becoming limiting for function. However, increasing evidence for the importance of local ATP and GTP pools, synthesised in close proximity to ATP- or GTP-consuming reactions, has fundamentally challenged our view of energy metabolism. It has become evident that cellular energy metabolism occurs in many specialised ‘microcompartments’, where energy in the form of NTPs is transferred preferentially from NTP-generating modules directly to NTP-consuming modules. Such energy channeling occurs when diffusion through the cytosol is limited, where these modules are physically close and, in particular, if the NTP-consuming reaction has a very high turnover,<ns4:italic>i.e</ns4:italic>. is very processive. Here, we summarise the evidence for these conclusions and describe new insights into the physiological importance and molecular mechanisms of energy channeling gained from recent studies. In particular, we describe the role of glycolytic enzymes for axonal vesicle transport and nucleoside diphosphate kinases for the functions of dynamins and dynamin-related GTPases.</ns4:p>" @default.
- W2616097232 created "2017-05-26" @default.
- W2616097232 creator A5002057344 @default.
- W2616097232 creator A5015976243 @default.
- W2616097232 creator A5017325892 @default.
- W2616097232 creator A5047545269 @default.
- W2616097232 creator A5066766564 @default.
- W2616097232 creator A5066969008 @default.
- W2616097232 creator A5074609427 @default.
- W2616097232 date "2017-07-18" @default.
- W2616097232 modified "2023-10-15" @default.
- W2616097232 title "The advantage of channeling nucleotides for very processive functions" @default.
- W2616097232 cites W132025854 @default.
- W2616097232 cites W1482512718 @default.
- W2616097232 cites W1483104407 @default.
- W2616097232 cites W1485189111 @default.
- W2616097232 cites W1509382673 @default.
- W2616097232 cites W1520111674 @default.
- W2616097232 cites W1527136114 @default.
- W2616097232 cites W1537605674 @default.
- W2616097232 cites W1539438534 @default.
- W2616097232 cites W1551234630 @default.
- W2616097232 cites W1561476652 @default.
- W2616097232 cites W1565036272 @default.
- W2616097232 cites W1571129442 @default.
- W2616097232 cites W1626150747 @default.
- W2616097232 cites W1628785169 @default.
- W2616097232 cites W1697383903 @default.
- W2616097232 cites W1849159432 @default.
- W2616097232 cites W1851906256 @default.
- W2616097232 cites W185383216 @default.
- W2616097232 cites W1943923304 @default.
- W2616097232 cites W1946944190 @default.
- W2616097232 cites W1964368285 @default.
- W2616097232 cites W1965597871 @default.
- W2616097232 cites W1967646152 @default.
- W2616097232 cites W1970356391 @default.
- W2616097232 cites W1970607892 @default.
- W2616097232 cites W1970851569 @default.
- W2616097232 cites W1971231602 @default.
- W2616097232 cites W1971910048 @default.
- W2616097232 cites W1972114620 @default.
- W2616097232 cites W1972238666 @default.
- W2616097232 cites W1972476228 @default.
- W2616097232 cites W1972812883 @default.
- W2616097232 cites W1973941736 @default.
- W2616097232 cites W1974086756 @default.
- W2616097232 cites W1975981956 @default.
- W2616097232 cites W1977258283 @default.
- W2616097232 cites W1977301516 @default.
- W2616097232 cites W1977598234 @default.
- W2616097232 cites W1978250223 @default.
- W2616097232 cites W1978608872 @default.
- W2616097232 cites W1978627586 @default.
- W2616097232 cites W1978724831 @default.
- W2616097232 cites W1980439311 @default.
- W2616097232 cites W1980804643 @default.
- W2616097232 cites W1980836133 @default.
- W2616097232 cites W1981431290 @default.
- W2616097232 cites W1981439819 @default.
- W2616097232 cites W1983965292 @default.
- W2616097232 cites W1986005076 @default.
- W2616097232 cites W1986199954 @default.
- W2616097232 cites W1986275801 @default.
- W2616097232 cites W1986602531 @default.
- W2616097232 cites W1986665005 @default.
- W2616097232 cites W1987146893 @default.
- W2616097232 cites W1988347671 @default.
- W2616097232 cites W1988418763 @default.
- W2616097232 cites W1992864103 @default.
- W2616097232 cites W1993735775 @default.
- W2616097232 cites W1994981454 @default.
- W2616097232 cites W1995206001 @default.
- W2616097232 cites W1995364852 @default.
- W2616097232 cites W1996344630 @default.
- W2616097232 cites W1996362914 @default.
- W2616097232 cites W1997282555 @default.
- W2616097232 cites W1998401961 @default.
- W2616097232 cites W1999469334 @default.
- W2616097232 cites W2000058843 @default.
- W2616097232 cites W2000428089 @default.
- W2616097232 cites W2000678571 @default.
- W2616097232 cites W2003265295 @default.
- W2616097232 cites W2004942398 @default.
- W2616097232 cites W2005189737 @default.
- W2616097232 cites W2006524711 @default.
- W2616097232 cites W2009329024 @default.
- W2616097232 cites W2010382848 @default.
- W2616097232 cites W2010982372 @default.
- W2616097232 cites W2011589808 @default.
- W2616097232 cites W2012182075 @default.
- W2616097232 cites W2013112818 @default.
- W2616097232 cites W2013720405 @default.
- W2616097232 cites W2014367387 @default.
- W2616097232 cites W2014688322 @default.
- W2616097232 cites W2017976110 @default.
- W2616097232 cites W2018861792 @default.
- W2616097232 cites W2018988493 @default.