FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2616103626> ?p ?o ?g. }

• W2616103626 endingPage "1211" @default.
• W2616103626 startingPage "1203" @default.
• W2616103626 abstract "Abstract Protein‐binding interactions are displacement reactions which have been implicated as the causative mechanisms in many drug–drug interactions. Thus, the aim of presented study was to analyse human serum albumin‐binding displacement interaction between two ligands, hypoglycaemic drug gliclazide and widely distributed plant flavonoid quercetin. Fluorescence analysis was used in order to investigate the effect of substances on intrinsic fluorescence of human serum albumin (HSA) and to define binding and quenching properties of ligand–albumin complexes in binary and ternary systems, respectively. Both ligands showed the ability to bind to HSA, although to a different extent. The displacement effect of one ligand from HSA by the other one has been described on the basis of the quenching curves and binding constants comparison for the binary and ternary systems. According to the fluorescence data analysis, gliclazide presents a substance with a lower binding capacity towards HSA compared with quercetin. Results also showed that the presence of quercetin hindered the interaction between HSA and gliclazide, as the binding constant for gliclazide in the ternary system was remarkably lower compared with the binary system. This finding indicates a possibility for an increase in the non‐bound fraction of gliclazide which can lead to its more significant hypoglycaemic effect. Additionally, secondary and tertiary structure conformational alterations of HSA upon binding of both ligands were investigated using synchronous fluorescence, circular dichroism and FT‐IR. Experimental data were complemented with molecular docking studies. Obtained results provide beneficial information about possible interference upon simultaneous co‐administration of the food/dietary supplement and drug." @default.
• W2616103626 created "2017-05-26" @default.
• W2616103626 creator A5008258219 @default.
• W2616103626 creator A5009301712 @default.
• W2616103626 creator A5016449058 @default.
• W2616103626 creator A5029316113 @default.
• W2616103626 creator A5034378363 @default.
• W2616103626 creator A5045541961 @default.
• W2616103626 creator A5048629525 @default.
• W2616103626 creator A5057712491 @default.
• W2616103626 creator A5090823299 @default.
• W2616103626 date "2017-05-16" @default.
• W2616103626 modified "2023-10-18" @default.
• W2616103626 title "Influence of quercetin on the interaction of gliclazide with human serum albumin – spectroscopic and docking approaches" @default.
• W2616103626 cites W1965346197 @default.
• W2616103626 cites W1966307646 @default.
• W2616103626 cites W1973238993 @default.
• W2616103626 cites W1975586699 @default.
• W2616103626 cites W1983467685 @default.
• W2616103626 cites W1983542230 @default.
• W2616103626 cites W1984590600 @default.
• W2616103626 cites W1989371402 @default.
• W2616103626 cites W1995894233 @default.
• W2616103626 cites W1995919471 @default.
• W2616103626 cites W1997689921 @default.
• W2616103626 cites W2006097728 @default.
• W2616103626 cites W2014950975 @default.
• W2616103626 cites W2016401253 @default.
• W2616103626 cites W2017057844 @default.
• W2616103626 cites W2020638348 @default.
• W2616103626 cites W2022520522 @default.
• W2616103626 cites W2029136818 @default.
• W2616103626 cites W2049629325 @default.
• W2616103626 cites W2060672233 @default.
• W2616103626 cites W2062102053 @default.
• W2616103626 cites W2066907882 @default.
• W2616103626 cites W2071046019 @default.
• W2616103626 cites W2085011133 @default.
• W2616103626 cites W2086455617 @default.
• W2616103626 cites W2101816854 @default.
• W2616103626 cites W2108142239 @default.
• W2616103626 cites W2126775578 @default.
• W2616103626 cites W2144312770 @default.
• W2616103626 cites W2149138461 @default.
• W2616103626 cites W2157304833 @default.
• W2616103626 cites W2160675185 @default.
• W2616103626 cites W2163388941 @default.
• W2616103626 cites W2164612869 @default.
• W2616103626 cites W2305596509 @default.
• W2616103626 cites W2319621644 @default.
• W2616103626 cites W2491458126 @default.
• W2616103626 cites W28070035 @default.
• W2616103626 cites W771321634 @default.
• W2616103626 cites W987090432 @default.
• W2616103626 doi "https://doi.org/10.1002/bio.3312" @default.
• W2616103626 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28513070" @default.
• W2616103626 hasPublicationYear "2017" @default.
• W2616103626 type Work @default.
• W2616103626 sameAs 2616103626 @default.
• W2616103626 citedByCount "22" @default.
• W2616103626 countsByYear W26161036262018 @default.
• W2616103626 countsByYear W26161036262019 @default.
• W2616103626 countsByYear W26161036262020 @default.
• W2616103626 countsByYear W26161036262021 @default.
• W2616103626 countsByYear W26161036262022 @default.
• W2616103626 countsByYear W26161036262023 @default.
• W2616103626 crossrefType "journal-article" @default.
• W2616103626 hasAuthorship W2616103626A5008258219 @default.
• W2616103626 hasAuthorship W2616103626A5009301712 @default.
• W2616103626 hasAuthorship W2616103626A5016449058 @default.
• W2616103626 hasAuthorship W2616103626A5029316113 @default.
• W2616103626 hasAuthorship W2616103626A5034378363 @default.
• W2616103626 hasAuthorship W2616103626A5045541961 @default.
• W2616103626 hasAuthorship W2616103626A5048629525 @default.
• W2616103626 hasAuthorship W2616103626A5057712491 @default.
• W2616103626 hasAuthorship W2616103626A5090823299 @default.
• W2616103626 hasConcept C107824862 @default.
• W2616103626 hasConcept C121332964 @default.
• W2616103626 hasConcept C121745418 @default.
• W2616103626 hasConcept C133571119 @default.
• W2616103626 hasConcept C134018914 @default.
• W2616103626 hasConcept C159110408 @default.
• W2616103626 hasConcept C165616093 @default.
• W2616103626 hasConcept C185592680 @default.
• W2616103626 hasConcept C2777448766 @default.
• W2616103626 hasConcept C2778004101 @default.
• W2616103626 hasConcept C2778597219 @default.
• W2616103626 hasConcept C2781263971 @default.
• W2616103626 hasConcept C32786932 @default.
• W2616103626 hasConcept C41685203 @default.
• W2616103626 hasConcept C55493867 @default.
• W2616103626 hasConcept C555293320 @default.
• W2616103626 hasConcept C62520636 @default.
• W2616103626 hasConcept C71240020 @default.
• W2616103626 hasConcept C71924100 @default.
• W2616103626 hasConcept C86803240 @default.
• W2616103626 hasConcept C91881484 @default.
• W2616103626 hasConceptScore W2616103626C107824862 @default.

• next