Matches in SemOpenAlex for { <https://semopenalex.org/work/W2616105619> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2616105619 abstract "Summary Pachydermoperiostosis is a very rare osteoarthrodermopathic disorder whose clinical and radiographic presentations may mimic those of acromegaly. In the evaluation of patients with acromegaloid appearances, pachydermoperiostosis should be considered as a differential diagnosis. In this article, we report a 17-year-old boy who presented with 2-year history of acral enlargement and facial appearance changes associated with joint pain and excessive sweating. He had been investigated extensively for acromegaly, and the final diagnosis was pachydermoperiostosis. Learning points There is a broad range of differential diagnosis for acromegaloid features such as acromegaly, pseudoacromegaly with severe insulin resistance, Marfan’s syndrome, McCune–Albright and a rare condition called pachydermoperiostosis. Once a patient is suspected to have acromegaly, the first step is biochemical testing to confirm the clinical diagnosis, followed by radiologic testing to determine the cause of the excess growth hormone (GH) secretion. The cause is a somatotroph adenoma of the pituitary in over 95 percent of cases. The first step is measurement of a serum insulin-like growth factor 1 (IGF1). A normal serum IGF1 concentration is strong evidence that the patient does not have acromegaly. If the serum IGF1 concentration is high (or equivocal), serum GH should be measured after oral glucose administration. Inadequate suppression of GH after a glucose load confirms the diagnosis of acromegaly. Once the presence of excess GH secretion is confirmed, the next step is pituitary magnetic resonance imaging (MRI). Atypical presentation warrants revision of the diagnosis. This patient presented with clubbing with no gigantism, which is expected in adolescent acromegalics as the growth spurt and epiphyseal plate closure have not taken place yet." @default.
- W2616105619 created "2017-05-26" @default.
- W2616105619 creator A5006781006 @default.
- W2616105619 creator A5034039683 @default.
- W2616105619 creator A5042150185 @default.
- W2616105619 date "2017-05-16" @default.
- W2616105619 modified "2023-10-17" @default.
- W2616105619 title "Pachydermoperiostosis: a rare mimicker of acromegaly" @default.
- W2616105619 cites W1964950849 @default.
- W2616105619 cites W1976727975 @default.
- W2616105619 cites W2018359951 @default.
- W2616105619 cites W2047257492 @default.
- W2616105619 cites W2070040521 @default.
- W2616105619 cites W2074809361 @default.
- W2616105619 cites W2112749979 @default.
- W2616105619 cites W2123430532 @default.
- W2616105619 cites W2307512719 @default.
- W2616105619 cites W2417801671 @default.
- W2616105619 cites W2788976368 @default.
- W2616105619 cites W59671044 @default.
- W2616105619 doi "https://doi.org/10.1530/edm-17-0029" @default.
- W2616105619 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5445428" @default.
- W2616105619 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28567291" @default.
- W2616105619 hasPublicationYear "2017" @default.
- W2616105619 type Work @default.
- W2616105619 sameAs 2616105619 @default.
- W2616105619 citedByCount "10" @default.
- W2616105619 countsByYear W26161056192017 @default.
- W2616105619 countsByYear W26161056192019 @default.
- W2616105619 countsByYear W26161056192021 @default.
- W2616105619 countsByYear W26161056192022 @default.
- W2616105619 countsByYear W26161056192023 @default.
- W2616105619 crossrefType "journal-article" @default.
- W2616105619 hasAuthorship W2616105619A5006781006 @default.
- W2616105619 hasAuthorship W2616105619A5034039683 @default.
- W2616105619 hasAuthorship W2616105619A5042150185 @default.
- W2616105619 hasBestOaLocation W26161056191 @default.
- W2616105619 hasConcept C126322002 @default.
- W2616105619 hasConcept C126838900 @default.
- W2616105619 hasConcept C134018914 @default.
- W2616105619 hasConcept C142724271 @default.
- W2616105619 hasConcept C143409427 @default.
- W2616105619 hasConcept C2777428134 @default.
- W2616105619 hasConcept C2777433750 @default.
- W2616105619 hasConcept C2777872460 @default.
- W2616105619 hasConcept C2779318953 @default.
- W2616105619 hasConcept C2780801072 @default.
- W2616105619 hasConcept C2984496839 @default.
- W2616105619 hasConcept C71315377 @default.
- W2616105619 hasConcept C71924100 @default.
- W2616105619 hasConcept C90924648 @default.
- W2616105619 hasConceptScore W2616105619C126322002 @default.
- W2616105619 hasConceptScore W2616105619C126838900 @default.
- W2616105619 hasConceptScore W2616105619C134018914 @default.
- W2616105619 hasConceptScore W2616105619C142724271 @default.
- W2616105619 hasConceptScore W2616105619C143409427 @default.
- W2616105619 hasConceptScore W2616105619C2777428134 @default.
- W2616105619 hasConceptScore W2616105619C2777433750 @default.
- W2616105619 hasConceptScore W2616105619C2777872460 @default.
- W2616105619 hasConceptScore W2616105619C2779318953 @default.
- W2616105619 hasConceptScore W2616105619C2780801072 @default.
- W2616105619 hasConceptScore W2616105619C2984496839 @default.
- W2616105619 hasConceptScore W2616105619C71315377 @default.
- W2616105619 hasConceptScore W2616105619C71924100 @default.
- W2616105619 hasConceptScore W2616105619C90924648 @default.
- W2616105619 hasLocation W26161056191 @default.
- W2616105619 hasLocation W26161056192 @default.
- W2616105619 hasLocation W26161056193 @default.
- W2616105619 hasLocation W26161056194 @default.
- W2616105619 hasLocation W26161056195 @default.
- W2616105619 hasOpenAccess W2616105619 @default.
- W2616105619 hasPrimaryLocation W26161056191 @default.
- W2616105619 hasRelatedWork W1329736 @default.
- W2616105619 hasRelatedWork W1966462916 @default.
- W2616105619 hasRelatedWork W1981300577 @default.
- W2616105619 hasRelatedWork W2006359830 @default.
- W2616105619 hasRelatedWork W2012488328 @default.
- W2616105619 hasRelatedWork W2046295479 @default.
- W2616105619 hasRelatedWork W2083210572 @default.
- W2616105619 hasRelatedWork W2127836255 @default.
- W2616105619 hasRelatedWork W2159072101 @default.
- W2616105619 hasRelatedWork W4247251534 @default.
- W2616105619 hasVolume "2017" @default.
- W2616105619 isParatext "false" @default.
- W2616105619 isRetracted "false" @default.
- W2616105619 magId "2616105619" @default.
- W2616105619 workType "article" @default.