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- W2616105892 abstract "Testicular germ cell tumors are the most common malignacies in young males. Two histological groups, seminoma and nonseminoma, differ morphologically and in malignant behaviour. Although a common cytogenetic feature is seen, amplification of 12p chromosomal region, development mechanisms of weakly aggressive seminoma and more aggressive nonseminoma are unknown. Molecular biology studies of these tumors are often contradictory. Occurence of structural genetic alterations was analysed in 18 seminoma and 22 nonseminoma for genes involved in a malignant tumour phenotype: CDH1, APC (cellular differentiation and adhesion); NME1 (cellular motility); TP53, CDKN2A, RB1 (cell cycle and genome integrity control); RAD51, MSH2, MLH1, BRCA1 (DNA damage repair); BAX (apoptosis); ABCG2 (resistance to xenobiotics). Genetic alterations, loss of heterozygosity (LOH) and microsatellite instability (MSI), were analysed using restriction fragments length or microsatellite repeats length polymorphisms. A difference betwen structural genetic alterations in seminoma and nonseminoma has been observed. Occurence of genetic alterations indicate an independent development of seminoma and nonseminoma, and clearly correlates with clinical behaviour of those tumours." @default.
- W2616105892 created "2017-05-26" @default.
- W2616105892 creator A5016502912 @default.
- W2616105892 date "2013-01-01" @default.
- W2616105892 modified "2023-09-27" @default.
- W2616105892 title "Strukturne promjene određenih gena u humanim tumorima zametnih stanica testisa" @default.
- W2616105892 hasPublicationYear "2013" @default.
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