Matches in SemOpenAlex for { <https://semopenalex.org/work/W2616140193> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2616140193 endingPage "233" @default.
- W2616140193 startingPage "227" @default.
- W2616140193 abstract "Low dose total body irradiation (TBI) administered in small fractional doses (5-10 cGy) for the treatment of disseminated malignancies such as chronic lymphocytic leukemia (CLL) and non-Hodgkin's lymphoma can be extremely toxic with substantial bone marrow depression. We elected to study bone marrow suppression following fractionated TBI in the rabbit. New Zealand white/female rabbits were thus treated with one of the following three schedules: (1) 3 fractions of 10 cGy per week; (2) 5 fractions of 10 cGy per week; and (3) 5 fractions of 25 cGy per week. Total doses ranged from 1050 to 2625 cGy and animals were sacrificed immediately, 4 weeks, or 8 weeks following completion of therapy. With the 10 cGy/day schedules, slight depression of total WBC counts and lymphocyte numbers occurred during and to the completion of irradiation followed by a rebound to greater than normal levels. With the 25 cGy schedule, a significant WBC and lymphocyte depression occurred at an accumulated dose of 1000 cGy and continued to decrease up to 2500 cGy, followed again by a rebound to greater than normal levels. The depression with the 25 cGy fractions was significantly greater than with the 10 cGy daily fractions. Thus, the severe and persistent peripheral blood count depression observed in CLL patients treated with TBI in small fractional doses was not reproduced in the normal rabbits. Possible explanations for this paradox are offered." @default.
- W2616140193 created "2017-05-26" @default.
- W2616140193 creator A5002120651 @default.
- W2616140193 creator A5010410691 @default.
- W2616140193 creator A5024834771 @default.
- W2616140193 date "1984-10-01" @default.
- W2616140193 modified "2023-09-23" @default.
- W2616140193 title "The paradoxes in patterns and mechanism of bone marrow regeneration after irradiation" @default.
- W2616140193 cites W1543601580 @default.
- W2616140193 cites W193514409 @default.
- W2616140193 cites W1981452363 @default.
- W2616140193 cites W1993034519 @default.
- W2616140193 cites W1999147003 @default.
- W2616140193 cites W2006238377 @default.
- W2616140193 cites W2029249390 @default.
- W2616140193 cites W2038783958 @default.
- W2616140193 cites W2042730130 @default.
- W2616140193 cites W2044938969 @default.
- W2616140193 cites W2051827070 @default.
- W2616140193 cites W2054049817 @default.
- W2616140193 cites W2083708532 @default.
- W2616140193 cites W2105505598 @default.
- W2616140193 cites W2132085924 @default.
- W2616140193 cites W2148794704 @default.
- W2616140193 cites W2215592690 @default.
- W2616140193 cites W2412982267 @default.
- W2616140193 cites W37957280 @default.
- W2616140193 cites W5387557 @default.
- W2616140193 doi "https://doi.org/10.1016/s0167-8140(84)80063-8" @default.
- W2616140193 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6396745" @default.
- W2616140193 hasPublicationYear "1984" @default.
- W2616140193 type Work @default.
- W2616140193 sameAs 2616140193 @default.
- W2616140193 citedByCount "14" @default.
- W2616140193 countsByYear W26161401932013 @default.
- W2616140193 crossrefType "journal-article" @default.
- W2616140193 hasAuthorship W2616140193A5002120651 @default.
- W2616140193 hasAuthorship W2616140193A5010410691 @default.
- W2616140193 hasAuthorship W2616140193A5024834771 @default.
- W2616140193 hasConcept C126322002 @default.
- W2616140193 hasConcept C139719470 @default.
- W2616140193 hasConcept C141071460 @default.
- W2616140193 hasConcept C162324750 @default.
- W2616140193 hasConcept C2776694085 @default.
- W2616140193 hasConcept C2776755627 @default.
- W2616140193 hasConcept C2776867660 @default.
- W2616140193 hasConcept C2777938653 @default.
- W2616140193 hasConcept C2778461978 @default.
- W2616140193 hasConcept C2778488018 @default.
- W2616140193 hasConcept C2778880498 @default.
- W2616140193 hasConcept C2780007613 @default.
- W2616140193 hasConcept C2989005 @default.
- W2616140193 hasConcept C509974204 @default.
- W2616140193 hasConcept C71924100 @default.
- W2616140193 hasConceptScore W2616140193C126322002 @default.
- W2616140193 hasConceptScore W2616140193C139719470 @default.
- W2616140193 hasConceptScore W2616140193C141071460 @default.
- W2616140193 hasConceptScore W2616140193C162324750 @default.
- W2616140193 hasConceptScore W2616140193C2776694085 @default.
- W2616140193 hasConceptScore W2616140193C2776755627 @default.
- W2616140193 hasConceptScore W2616140193C2776867660 @default.
- W2616140193 hasConceptScore W2616140193C2777938653 @default.
- W2616140193 hasConceptScore W2616140193C2778461978 @default.
- W2616140193 hasConceptScore W2616140193C2778488018 @default.
- W2616140193 hasConceptScore W2616140193C2778880498 @default.
- W2616140193 hasConceptScore W2616140193C2780007613 @default.
- W2616140193 hasConceptScore W2616140193C2989005 @default.
- W2616140193 hasConceptScore W2616140193C509974204 @default.
- W2616140193 hasConceptScore W2616140193C71924100 @default.
- W2616140193 hasIssue "3" @default.
- W2616140193 hasLocation W26161401931 @default.
- W2616140193 hasLocation W26161401932 @default.
- W2616140193 hasOpenAccess W2616140193 @default.
- W2616140193 hasPrimaryLocation W26161401931 @default.
- W2616140193 hasRelatedWork W1629649714 @default.
- W2616140193 hasRelatedWork W1983836789 @default.
- W2616140193 hasRelatedWork W2017298652 @default.
- W2616140193 hasRelatedWork W2367707652 @default.
- W2616140193 hasRelatedWork W2377386508 @default.
- W2616140193 hasRelatedWork W2382769489 @default.
- W2616140193 hasRelatedWork W2393821595 @default.
- W2616140193 hasRelatedWork W2463756048 @default.
- W2616140193 hasRelatedWork W3211657369 @default.
- W2616140193 hasRelatedWork W2784834472 @default.
- W2616140193 hasVolume "2" @default.
- W2616140193 isParatext "false" @default.
- W2616140193 isRetracted "false" @default.
- W2616140193 magId "2616140193" @default.
- W2616140193 workType "article" @default.