FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2616150698> ?p ?o ?g. }

• W2616150698 abstract "Atrial fibrillation is the most common persistent cardiac arrhythmia, and it is not well controlled by present drugs. Because some resin acids open voltage-gated potassium channels and reduce neuronal excitability, we explored the effects of the resin acid isopimaric acid (IPA) on action potentials and ion currents in cardiomyocytes.Spontaneously beating mouse atrial HL-1 cells were investigated with the whole-cell patch-clamp technique.1-25 μmol L-1 IPA reduced the action potential frequency by up to 50%. The effect of IPA on six different voltage-gated ion channels was investigated; most voltage-dependent parameters of ion channel gating were shifted in the negative direction along the voltage axis, consistent with a hypothesis that a lipophilic and negatively charged compound binds to the lipid membrane close to the positively charged voltage sensor of the ion channels. The major finding was that IPA inactivated sodium channels and L- and T-type calcium channels and activated the rapidly activating potassium channel and the transient outward potassium channel. Computer simulations of IPA effects on all of the ion currents were consistent with a reduced excitability, and they also showed that effects on the Na channel played the largest role to reduce the action potential frequency. Finally, induced arrhythmia in the HL-1 cells was reversed by IPA.Low concentrations of IPA reduced the action potential frequency and restored regular firing by altering the voltage dependencies of several voltage-gated ion channels. These findings can form the basis for a new pharmacological strategy to treat atrial fibrillation." @default.
• W2616150698 created "2017-05-26" @default.
• W2616150698 creator A5022458121 @default.
• W2616150698 creator A5054685745 @default.
• W2616150698 creator A5059848596 @default.
• W2616150698 creator A5063202649 @default.
• W2616150698 date "2017-06-09" @default.
• W2616150698 modified "2023-10-01" @default.
• W2616150698 title "Isopimaric acid - a multi-targeting ion channel modulator reducing excitability and arrhythmicity in a spontaneously beating mouse atrial cell line" @default.
• W2616150698 cites W111522839 @default.
• W2616150698 cites W1522393179 @default.
• W2616150698 cites W1629647345 @default.
• W2616150698 cites W1746749941 @default.
• W2616150698 cites W1924098982 @default.
• W2616150698 cites W1973611043 @default.
• W2616150698 cites W1979118105 @default.
• W2616150698 cites W1994446230 @default.
• W2616150698 cites W1994452561 @default.
• W2616150698 cites W1997601961 @default.
• W2616150698 cites W2000072979 @default.
• W2616150698 cites W2002374666 @default.
• W2616150698 cites W2003013939 @default.
• W2616150698 cites W2008045438 @default.
• W2616150698 cites W2012153678 @default.
• W2616150698 cites W2012680333 @default.
• W2616150698 cites W2017448752 @default.
• W2616150698 cites W2026411976 @default.
• W2616150698 cites W2030036563 @default.
• W2616150698 cites W2038538268 @default.
• W2616150698 cites W2042625973 @default.
• W2616150698 cites W2047808952 @default.
• W2616150698 cites W2060258595 @default.
• W2616150698 cites W2063344460 @default.
• W2616150698 cites W2063435859 @default.
• W2616150698 cites W2070393344 @default.
• W2616150698 cites W2072027195 @default.
• W2616150698 cites W2074455154 @default.
• W2616150698 cites W2075175982 @default.
• W2616150698 cites W2075977700 @default.
• W2616150698 cites W2076555249 @default.
• W2616150698 cites W2077023701 @default.
• W2616150698 cites W2093707571 @default.
• W2616150698 cites W2094677101 @default.
• W2616150698 cites W2107709545 @default.
• W2616150698 cites W2114775432 @default.
• W2616150698 cites W2117453669 @default.
• W2616150698 cites W2120342952 @default.
• W2616150698 cites W2125693777 @default.
• W2616150698 cites W2126403835 @default.
• W2616150698 cites W2128995864 @default.
• W2616150698 cites W2130029281 @default.
• W2616150698 cites W2138409790 @default.
• W2616150698 cites W2139845545 @default.
• W2616150698 cites W2143518969 @default.
• W2616150698 cites W2146890174 @default.
• W2616150698 cites W2158751833 @default.
• W2616150698 cites W2158784397 @default.
• W2616150698 cites W2163212469 @default.
• W2616150698 cites W2167886664 @default.
• W2616150698 cites W2274328802 @default.
• W2616150698 cites W2313547185 @default.
• W2616150698 cites W2582910384 @default.
• W2616150698 cites W2587096332 @default.
• W2616150698 doi "https://doi.org/10.1111/apha.12895" @default.
• W2616150698 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28514017" @default.
• W2616150698 hasPublicationYear "2017" @default.
• W2616150698 type Work @default.
• W2616150698 sameAs 2616150698 @default.
• W2616150698 citedByCount "15" @default.
• W2616150698 countsByYear W26161506982017 @default.
• W2616150698 countsByYear W26161506982018 @default.
• W2616150698 countsByYear W26161506982020 @default.
• W2616150698 countsByYear W26161506982021 @default.
• W2616150698 countsByYear W26161506982022 @default.
• W2616150698 countsByYear W26161506982023 @default.
• W2616150698 crossrefType "journal-article" @default.
• W2616150698 hasAuthorship W2616150698A5022458121 @default.
• W2616150698 hasAuthorship W2616150698A5054685745 @default.
• W2616150698 hasAuthorship W2616150698A5059848596 @default.
• W2616150698 hasAuthorship W2616150698A5063202649 @default.
• W2616150698 hasBestOaLocation W26161506982 @default.
• W2616150698 hasConcept C12554922 @default.
• W2616150698 hasConcept C126322002 @default.
• W2616150698 hasConcept C145148216 @default.
• W2616150698 hasConcept C147944092 @default.
• W2616150698 hasConcept C170493617 @default.
• W2616150698 hasConcept C178790620 @default.
• W2616150698 hasConcept C181911157 @default.
• W2616150698 hasConcept C185263204 @default.
• W2616150698 hasConcept C185592680 @default.
• W2616150698 hasConcept C194544171 @default.
• W2616150698 hasConcept C2779161974 @default.
• W2616150698 hasConcept C37088560 @default.
• W2616150698 hasConcept C50254741 @default.
• W2616150698 hasConcept C50952357 @default.
• W2616150698 hasConcept C517785266 @default.
• W2616150698 hasConcept C537181965 @default.
• W2616150698 hasConcept C55493867 @default.
• W2616150698 hasConcept C71924100 @default.
• W2616150698 hasConcept C83743174 @default.

• next