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- W2616166953 abstract "Epigenetics, a term with many meanings, can be broadly defined as the study of dynamic states of the genome. Ciliates, a clade of unicellular eukaryotes, can teach us about the intersection of epigenetics and evolution due to the advantages of working with cultivable ciliate lineages, plus their tendency to express extreme phenotypes such as heritable doublet morphology. Moreover, ciliates provide a powerful model for studying epigenetics given the presence of dimorphic nuclei - a somatic macronucleus and germline micronucleus - within each cell. Here, we exemplify the power of studying ciliates to learn about epigenetic phenomena. We highlight classical examples from morphology and physiology including cortical inheritance, mating type determination, and serotype expression. In addition, we detail molecular studies of epigenetic phenomena, including: DNA elimination; alternative processing and unscrambling; and copy number determination. Based on the implications of these studies, we discuss epigenetics as a possible functional mechanism for rapid speciation in ciliates." @default.
- W2616166953 created "2017-05-26" @default.
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- W2616166953 date "2017-10-01" @default.
- W2616166953 modified "2023-10-18" @default.
- W2616166953 title "Insights into transgenerational epigenetics from studies of ciliates" @default.
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- W2616166953 doi "https://doi.org/10.1016/j.ejop.2017.05.004" @default.
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