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• W2616191509 abstract "Chlamydiatrachomatis (Ct) infection causes significant morbidity. In vitro studies demonstrate that Ct growth inhibition occurs by interferon-gamma (IFN-γ)–mediated depletion of intracellular tryptophan, and some Ct strains utilize extracellular indole to restore tryptophan levels. Whether tryptophan levels are associated with Ct infection clearance in humans remains unknown. We evaluated tryptophan, indole, and IFN-γ levels in cervicovaginal lavages from women with either naturally cleared or persisting Ct infection. Women who cleared infection had significantly lower tryptophan levels and trended toward lower IFN-γ levels compared to women with persisting infection. Due to its volatility, indole was not measurable in either group." @default.
• W2616191509 created "2017-05-26" @default.
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• W2616191509 date "2017-05-17" @default.
• W2616191509 modified "2023-09-25" @default.
• W2616191509 title "Lower Levels of Cervicovaginal Tryptophan Are Associated With Natural Clearance of Chlamydia in Women" @default.
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• W2616191509 doi "https://doi.org/10.1093/infdis/jix240" @default.
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