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• W2616200709 endingPage "1814" @default.
• W2616200709 startingPage "1804" @default.
• W2616200709 abstract "The heterotrimeric kinase AMPK acts as an energy sensor to coordinate cell metabolism with environmental status in species from yeast through humans. Low intracellular ATP leads to AMPK activation through phosphorylation of the activation loop within the catalytic subunit. Other environmental stresses also activate AMPK, but it is unclear whether cellular energy status affects AMPK activation under these conditions. Fission yeast AMPK catalytic subunit Ssp2 is phosphorylated at Thr-189 by the upstream kinase Ssp1 in low-glucose conditions, similar to other systems. Here we find that hyperosmotic stress induces strong phosphorylation of Ssp2-T189 by Ssp1. Ssp2-pT189 during osmotic stress is transient and leads to transient regulation of AMPK targets, unlike sustained activation by low glucose. Cells lacking this activation mechanism fail to proliferate after hyperosmotic stress. Activation during osmotic stress requires energy sensing by AMPK heterotrimer, and osmotic stress leads to decreased intracellular ATP levels. We observed mitochondrial fission during osmotic stress, but blocking fission did not affect AMPK activation. Stress-activated kinases Sty1 and Pmk1 did not promote AMPK activation but contributed to subsequent inactivation. Our results show that osmotic stress induces transient energy stress, and AMPK activation allows cells to manage this energy stress for proliferation in new osmotic states." @default.
• W2616200709 created "2017-05-26" @default.
• W2616200709 creator A5075839935 @default.
• W2616200709 creator A5081650906 @default.
• W2616200709 date "2017-07-01" @default.
• W2616200709 modified "2023-09-26" @default.
• W2616200709 title "Transient activation of fission yeast AMPK is required for cell proliferation during osmotic stress" @default.
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• W2616200709 doi "https://doi.org/10.1091/mbc.e17-04-0235" @default.
• W2616200709 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5491188" @default.
• W2616200709 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28515144" @default.
• W2616200709 hasPublicationYear "2017" @default.
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