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- W2616232212 abstract "Early change of the blood-brain barrier (BBB) following laser hyperthermia was studied experimentally. Laser hyperthermia was applied to rat brains. Trypan blue was injected zero to ten minutes after laser irradiation. Fixed brains were prepared for macroscopic examination and detailed examination using image analyzer. On macroscopic examination the BBB started to open 6 minutes after laser irradiation.However examination by image analyzer revealed that the BBB started to open 4 minutes after laser irradiation. Transmission electron microscopic examination disclosed no significant change in the capillary endothelium at 4 minutes after laser irradiation but showed endothelial infolding vacuoles and swollen astrocytic foot processes at 6 minutes after irradiation. We concluded that the BBB started to open 4 minutes after laser hyperthermia. The mechanism of the BBB opening following laser hyperthermia is probably due to the impaired endothelial membrane potentials." @default.
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- W2616232212 date "1990-01-01" @default.
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- W2616232212 doi "https://doi.org/10.2530/jslsm1980.11.supplement_243" @default.
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