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- W2616284760 endingPage "109" @default.
- W2616284760 startingPage "109" @default.
- W2616284760 abstract "Master developmental pathways, such as Notch, Wnt, and Hedgehog, are signaling systems that control proliferation, cell death, motility, migration, and stemness. These systems are not only commonly activated in many solid tumors, where they drive or contribute to cancer initiation, but also in primary and metastatic tumor development. The reactivation of developmental pathways in cancer stroma favors the development of cancer stem cells and allows their maintenance, indicating these signaling pathways as particularly attractive targets for efficient anticancer therapies, especially in advanced primary tumors and metastatic cancers. Metastasis is the worst feature of cancer development. This feature results from a cascade of events emerging from the hijacking of epithelial-mesenchymal transition, angiogenesis, migration, and invasion by transforming cells and is associated with poor survival, drug resistance, and tumor relapse. In the present review, we summarize and discuss experimental data suggesting pivotal roles for developmental pathways in cancer development and metastasis, considering the therapeutic potential. Emerging targeted antimetastatic therapies based on Notch, Wnt, and Hedgehog pathways are also discussed." @default.
- W2616284760 created "2017-05-26" @default.
- W2616284760 creator A5005050372 @default.
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- W2616284760 creator A5084464465 @default.
- W2616284760 creator A5084804501 @default.
- W2616284760 date "2017-01-01" @default.
- W2616284760 modified "2023-10-18" @default.
- W2616284760 title "Developmental pathways associated with cancer metastasis: Notch, Wnt, and Hedgehog" @default.
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