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- W2616315171 abstract "The mycobacterial cell wall is crucial to the host-pathogen interface, because it provides a barrier against antibiotics and the host immune response. In addition, cell wall lipids are mycobacterial virulence factors. The mycobacterial membrane protein large (MmpL) proteins are cell wall lipid transporters that are important for basic mycobacterial physiology and Mycobacterium tuberculosis pathogenesis. MmpL3 and MmpL11 are conserved across pathogenic and nonpathogenic mycobacteria, a feature consistent with an important role in the basic physiology of the bacterium. MmpL3 is essential and transports trehalose monomycolate to the mycobacterial surface. In this report, we characterize the role of MmpL11 in M. tuberculosis. M. tuberculosismmpL11 mutants have altered biofilms associated with lower levels of mycolic acid wax ester and long-chain triacylglycerols than those for wild-type bacteria. While the growth rate of the mmpL11 mutant is similar to that of wild-type M. tuberculosis in macrophages, the mutant exhibits impaired survival in an in vitro granuloma model. Finally, we show that the survival or recovery of the mmpL11 mutant is impaired when it is incubated under conditions of nutrient and oxygen starvation. Our results suggest that MmpL11 and its cell wall lipid substrates are important for survival in the context of adaptive immune pressure and for nonreplicating persistence, both of which are critically important aspects of M. tuberculosis pathogenicity." @default.
- W2616315171 created "2017-05-26" @default.
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- W2616315171 date "2017-08-01" @default.
- W2616315171 modified "2023-10-11" @default.
- W2616315171 title "The Mycobacterium tuberculosis MmpL11 Cell Wall Lipid Transporter Is Important for Biofilm Formation, Intracellular Growth, and Nonreplicating Persistence" @default.
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- W2616315171 cites W1934542416 @default.
- W2616315171 cites W1954303926 @default.
- W2616315171 cites W1958432512 @default.
- W2616315171 cites W197096261 @default.
- W2616315171 cites W1974402216 @default.
- W2616315171 cites W1976870904 @default.
- W2616315171 cites W1977138279 @default.
- W2616315171 cites W1977959789 @default.
- W2616315171 cites W1978212400 @default.
- W2616315171 cites W1990746686 @default.
- W2616315171 cites W1991233072 @default.
- W2616315171 cites W1996907187 @default.
- W2616315171 cites W2005036750 @default.
- W2616315171 cites W2005797236 @default.
- W2616315171 cites W2012579922 @default.
- W2616315171 cites W2017513650 @default.
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- W2616315171 cites W2035787643 @default.
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- W2616315171 cites W2067327881 @default.
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- W2616315171 doi "https://doi.org/10.1128/iai.00131-17" @default.
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