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• W2616363315 abstract "Abstract Background and objective We analysed baseline and kinetic characteristics of lipid metabolism during the first month of bitherapy in patients with chronic hepatitis C genotype 1 (CHC-1). Patients and methods A longitudinal, prospective study including 99 naive CHC-1 patients with liver biopsy who were treated with bitherapy. Our patients were assigned to one of the 5 different “degrees of lipid requirement” that we established depending on the degree of liver fibrosis, baseline viral load and infectivity ratio (ratio between the median level of triglycerides and high density lipoproteins-cholesterol during the first month). The goal was to achieve “a favourable lipid metabolism” (FLM) by establishing a necessary minimum level of low density lipoproteins (LDL)-cholesterol during this period for each one of them. We also analysed the relationship with the rate of sustained virological response. Results Patients with liver fibrosis F3-F4 who had higher baseline levels of LDL-cholesterol achieved higher rates of sustained virological response. Those patients who had a lower value of infectivity ratio and median levels of LDL-cholesterol during the first month of bitherapy also achieved higher rates of sustained virological response: SVR group 100 (23) mg/dl against non-SVR group: 89 (28) mg/dl; odds ratio 1.1; 95% confidence interval (1.0–1.2); P P  = 0.013). Patients with sustained virological response had higher rates of FLM. Conclusions Not every patient with CHC-1 has the same lipid kinetics during the first month of bitherapy, and it is necessary to achieve a sustained virological response and/or a FLM to keep higher plasma levels of LDL-cholesterol during this period. Those subjects without FLM could benefit from statins." @default.
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• W2616363315 date "2015-06-01" @default.
• W2616363315 modified "2023-10-18" @default.
• W2616363315 title "Lipid kinetics during dual antiviral therapy in patients with chronic hepatitis C" @default.
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• W2616363315 doi "https://doi.org/10.1016/j.medcle.2015.12.031" @default.
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• W2616363315 hasPublicationYear "2015" @default.
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