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• W2616366890 endingPage "5748" @default.
• W2616366890 startingPage "5743" @default.
• W2616366890 abstract "Significance The calcium channel of sperm—CatSper—is vital for male fertility. CatSper is activated by the hormone progesterone, but its pharmacological profile is not well studied. By exploring steroid selectivity of CatSper activation, we found one additional agonist—pregnenolone sulfate—and the two plant-derived inhibitors pristimerin and lupeol. By averting sperm hyperactivation, both inhibitors can prevent fertilization, thus acting as contraceptive agents. Additionally, by exploring CatSper regulation by endogenous steroids, we explain why CatSper is silent within the male reproductive tract and is only activated in close proximity to the egg. Interestingly, both testosterone and hydrocortisone antagonize the action of progesterone at physiological concentrations, which may explain why elevated levels of these steroids in the female organism affect fertility." @default.
• W2616366890 created "2017-05-26" @default.
• W2616366890 creator A5048310294 @default.
• W2616366890 creator A5054974974 @default.
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• W2616366890 date "2017-05-15" @default.
• W2616366890 modified "2023-10-15" @default.
• W2616366890 title "Regulation of the sperm calcium channel CatSper by endogenous steroids and plant triterpenoids" @default.
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• W2616366890 doi "https://doi.org/10.1073/pnas.1700367114" @default.
• W2616366890 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5465908" @default.
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• W2616366890 hasPublicationYear "2017" @default.
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