FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2616388670> ?p ?o ?g. }

• W2616388670 endingPage "69537" @default.
• W2616388670 startingPage "69527" @default.
• W2616388670 abstract "// Gongying Li 1, * , Ping Jing 2, * , Zhidong Liu 3, * , Zhiruo Li 4 , Hongxia Ma 5 , Wenzhen Tu 2, # , Wei Zhang 2, # and Chuanjun Zhuo 2, 1, 6, 7, # 1 Insitute of Mental health, Jining Medical University, Jining, 272067, China 2 Department of Psychiatry, Wenzhou Seventh People’s Hospital, Wenzhou, Zhejiang Province, 325000, China 3 Tianjin Fourth Central Hospital of Tianjin Medical University, Tianjin, 300000, China 4 Department of Neurology, The Affiliated Hospital of Jining Medical University, Jining, 272000, China 5 Department of Psychiatry, The Second Affiliated Hospital of Jining Medical University, Jining, 272051, China 6 Department of Psychiatric Neuroimaging Laboratory, Tianjin Anding Hospital, Tianjin Mental Health Center, Tianjin 300222, China 7 Department of Psychiatry, Tianjin Anning Hospital, Tianjin 300300, China * These authors have contributed equally to this work # Co First authors Correspondence to: Chuanjun Zhuo, email: chuanjunzhuotjmh@163.com Keywords: brain-derived neurotrophic factor (BDNF), psychological stress, fluoxetine, serotonin Received: January 23, 2017      Accepted: April 29, 2017      Published: May 15, 2017 ABSTRACT SSRI antidepressant fluoxetine is widely used to treat psychological stress related disorders, however the underlying working mechanisms is not fully understood, as SSRIs can rapidly increase the extracellular serotonin levels but it normally takes weeks to reveal their therapeutic effect in the stress-related psychological disorders. Our previous study demonstrated that purely psychological stress without any physic stimuli induces a biphasic change in the expression of brain-derived neurotrophic factor (BDNF), which immediately decrease and then gradually increase after the stress; and that the latter BDNF increase in response to the psychological stress involves the activation of serotonin system. To investigate the role of BDNF in the fluoxetine treatment for stress-related psychological disorders, we examined the mRNA and protein levels of BDNF in the brain of Sprague-Dawley (SD) rats, which were pretreated with fluoxetine at 10 mg/kg or vehicle solution for 14 days, over 24 hour after an acute psychological stress exposure. In situ hybridization and immunohistochemistry were performed to detect the expression of BDNF at different time points in various brain regions after the psychological stress. We found that fluoxetine treatment completely blocked the BDNF decrease induced by the psychological stress, and also enhanced the gradual increase in the expression of BDNF in most of the brain regions except VTA after the psychological stress. The results suggest that the enhancement in BDNF levels induced by chronic fluoxetine treatment mediates the therapeutic effect against psychological stress." @default.
• W2616388670 created "2017-05-26" @default.
• W2616388670 creator A5005997943 @default.
• W2616388670 creator A5021519459 @default.
• W2616388670 creator A5022293237 @default.
• W2616388670 creator A5036514805 @default.
• W2616388670 creator A5037660639 @default.
• W2616388670 creator A5076699095 @default.
• W2616388670 creator A5087792260 @default.
• W2616388670 creator A5091072052 @default.
• W2616388670 date "2017-05-15" @default.
• W2616388670 modified "2023-10-16" @default.
• W2616388670 title "Beneficial effect of fluoxetine treatment aganist psychological stress is mediated by increasing BDNF expression in selected brain areas" @default.
• W2616388670 cites W1556200960 @default.
• W2616388670 cites W1914011667 @default.
• W2616388670 cites W1958676502 @default.
• W2616388670 cites W1965331012 @default.
• W2616388670 cites W1967075670 @default.
• W2616388670 cites W1969542970 @default.
• W2616388670 cites W1986039782 @default.
• W2616388670 cites W1990568540 @default.
• W2616388670 cites W1992584151 @default.
• W2616388670 cites W1993656297 @default.
• W2616388670 cites W1993983321 @default.
• W2616388670 cites W1999399598 @default.
• W2616388670 cites W2000209446 @default.
• W2616388670 cites W2000273941 @default.
• W2616388670 cites W2002601834 @default.
• W2616388670 cites W2007862317 @default.
• W2616388670 cites W2008826113 @default.
• W2616388670 cites W2010269783 @default.
• W2616388670 cites W2013154464 @default.
• W2616388670 cites W2019939591 @default.
• W2616388670 cites W2021824998 @default.
• W2616388670 cites W2023826995 @default.
• W2616388670 cites W2025950603 @default.
• W2616388670 cites W2026762071 @default.
• W2616388670 cites W2029046909 @default.
• W2616388670 cites W2035683658 @default.
• W2616388670 cites W2045946829 @default.
• W2616388670 cites W2051556001 @default.
• W2616388670 cites W2054695075 @default.
• W2616388670 cites W2056205520 @default.
• W2616388670 cites W2058006510 @default.
• W2616388670 cites W2059858969 @default.
• W2616388670 cites W2060550784 @default.
• W2616388670 cites W2061081311 @default.
• W2616388670 cites W2061473276 @default.
• W2616388670 cites W2061494582 @default.
• W2616388670 cites W2062717339 @default.
• W2616388670 cites W2063797063 @default.
• W2616388670 cites W2065340410 @default.
• W2616388670 cites W2068880746 @default.
• W2616388670 cites W2070603219 @default.
• W2616388670 cites W2071804866 @default.
• W2616388670 cites W2075620663 @default.
• W2616388670 cites W2080433636 @default.
• W2616388670 cites W2085033756 @default.
• W2616388670 cites W2089739459 @default.
• W2616388670 cites W2099299312 @default.
• W2616388670 cites W2104156945 @default.
• W2616388670 cites W2123011060 @default.
• W2616388670 cites W2134083528 @default.
• W2616388670 cites W2134268790 @default.
• W2616388670 cites W2142789104 @default.
• W2616388670 cites W2156331665 @default.
• W2616388670 cites W2161365979 @default.
• W2616388670 cites W2163520430 @default.
• W2616388670 cites W2211535413 @default.
• W2616388670 cites W2287169485 @default.
• W2616388670 cites W2345236994 @default.
• W2616388670 cites W2525035643 @default.
• W2616388670 cites W2537316755 @default.
• W2616388670 cites W2581597337 @default.
• W2616388670 doi "https://doi.org/10.18632/oncotarget.17891" @default.
• W2616388670 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5642497" @default.
• W2616388670 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29050222" @default.
• W2616388670 hasPublicationYear "2017" @default.
• W2616388670 type Work @default.
• W2616388670 sameAs 2616388670 @default.
• W2616388670 citedByCount "16" @default.
• W2616388670 countsByYear W26163886702017 @default.
• W2616388670 countsByYear W26163886702018 @default.
• W2616388670 countsByYear W26163886702019 @default.
• W2616388670 countsByYear W26163886702020 @default.
• W2616388670 countsByYear W26163886702021 @default.
• W2616388670 countsByYear W26163886702022 @default.
• W2616388670 countsByYear W26163886702023 @default.
• W2616388670 crossrefType "journal-article" @default.
• W2616388670 hasAuthorship W2616388670A5005997943 @default.
• W2616388670 hasAuthorship W2616388670A5021519459 @default.
• W2616388670 hasAuthorship W2616388670A5022293237 @default.
• W2616388670 hasAuthorship W2616388670A5036514805 @default.
• W2616388670 hasAuthorship W2616388670A5037660639 @default.
• W2616388670 hasAuthorship W2616388670A5076699095 @default.
• W2616388670 hasAuthorship W2616388670A5087792260 @default.
• W2616388670 hasAuthorship W2616388670A5091072052 @default.
• W2616388670 hasBestOaLocation W26163886701 @default.

• next