FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2616408378> ?p ?o ?g. }

• W2616408378 abstract "Background Cigarette smoking plays a major role in cardiovascular diseases. The acute effects of cigarette smoking produce central nervous system–mediated activation of the sympathetic nervous system. The overactive sympathetic nervous system stimulates the secretion of serotonin (5‐ HT ) and catecholamine into blood at supraphysiological levels. The correlation between these pathological conditions induced by smoking and the increased risk of thrombosis has not been thoroughly investigated. The goal of our study was to explore cigarette smoking–associated changes in platelet biology mediated by elevated 5‐ HT and catecholamine levels in blood plasma. Methods and Results Using blood samples collected from healthy nonsmokers and smokers (15 minutes after smoking), we determined that cigarette smoking increased the plasma 5‐ HT /catecholamine concentration by several fold and the percent aggregation of platelets 2‐fold. Liquid chromatography–tandem mass spectrometry analysis of proteins eluted from platelet plasma membranes of smokers and nonsmokers demonstrated that GTP ase‐activating proteins and proteins participating in the actin cytoskeletal network were differentially and significantly elevated in smokers' platelet membranes compared with those of nonsmokers. Interestingly, Matrix‐assisted laser desorption/ionization–mass spectrometry analyses of the glycans eluted from platelet plasma membranes of the smokers demonstrated that the level and structures of glycans are different from the nonsmokers' platelet surface glycans. Pharmacological blockade of 5‐ HT or catecholamine receptors counteracted the 5‐ HT /catecholamine‐mediated aggregation and altered the level and composition of glycan on platelet surfaces. Conclusions Based on our findings, we propose that smoking‐associated 5‐ HT /catecholamine signaling accelerates the trafficking dynamics of platelets, and this remodels the surface proteins and glycans and predisposes platelets to hyperactive levels. Smokers' platelets also had correspondingly higher resting concentrations of intracellular calcium and transglutaminase activity. These findings suggest a link among smoking, platelet 5‐ HT , catecholamine signaling, and their downstream effectors—including phospholipase C and inositol‐1,4,5‐triphosphate pathways—resulting in an increased tonic level of platelet activation in smokers." @default.
• W2616408378 created "2017-05-26" @default.
• W2616408378 creator A5012994303 @default.
• W2616408378 creator A5030566671 @default.
• W2616408378 creator A5044262695 @default.
• W2616408378 creator A5073577112 @default.
• W2616408378 creator A5073800945 @default.
• W2616408378 creator A5077844747 @default.
• W2616408378 creator A5080261804 @default.
• W2616408378 creator A5082717785 @default.
• W2616408378 creator A5082857119 @default.
• W2616408378 creator A5083220730 @default.
• W2616408378 date "2017-05-05" @default.
• W2616408378 modified "2023-10-11" @default.
• W2616408378 title "Cigarette Smoking‐Associated Alterations in Serotonin/Adrenalin Signaling Pathways of Platelets" @default.
• W2616408378 cites W1899700659 @default.
• W2616408378 cites W1964723513 @default.
• W2616408378 cites W1968415875 @default.
• W2616408378 cites W1992029300 @default.
• W2616408378 cites W2006847221 @default.
• W2616408378 cites W2009852374 @default.
• W2616408378 cites W2014769550 @default.
• W2616408378 cites W2017704303 @default.
• W2616408378 cites W2025015082 @default.
• W2616408378 cites W2025713994 @default.
• W2616408378 cites W2033337560 @default.
• W2616408378 cites W2039448868 @default.
• W2616408378 cites W2043368216 @default.
• W2616408378 cites W2044241495 @default.
• W2616408378 cites W2048605574 @default.
• W2616408378 cites W2052176508 @default.
• W2616408378 cites W2053305824 @default.
• W2616408378 cites W2056765905 @default.
• W2616408378 cites W2060004248 @default.
• W2616408378 cites W2061712065 @default.
• W2616408378 cites W2068586063 @default.
• W2616408378 cites W2071405646 @default.
• W2616408378 cites W2071532869 @default.
• W2616408378 cites W2077939074 @default.
• W2616408378 cites W2079961396 @default.
• W2616408378 cites W2080752012 @default.
• W2616408378 cites W2093905859 @default.
• W2616408378 cites W2098276516 @default.
• W2616408378 cites W2099380661 @default.
• W2616408378 cites W2104318497 @default.
• W2616408378 cites W2105541876 @default.
• W2616408378 cites W2106395903 @default.
• W2616408378 cites W2109204050 @default.
• W2616408378 cites W2113419485 @default.
• W2616408378 cites W2120002575 @default.
• W2616408378 cites W2121900171 @default.
• W2616408378 cites W2141399461 @default.
• W2616408378 cites W2148841524 @default.
• W2616408378 cites W2151663099 @default.
• W2616408378 cites W2168514834 @default.
• W2616408378 cites W2215280524 @default.
• W2616408378 cites W2290937015 @default.
• W2616408378 cites W2294883346 @default.
• W2616408378 cites W2299087924 @default.
• W2616408378 cites W2337353829 @default.
• W2616408378 cites W2437988774 @default.
• W2616408378 cites W2543636523 @default.
• W2616408378 cites W4236918658 @default.
• W2616408378 cites W4383677066 @default.
• W2616408378 doi "https://doi.org/10.1161/jaha.116.005465" @default.
• W2616408378 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5524091" @default.
• W2616408378 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28522678" @default.
• W2616408378 hasPublicationYear "2017" @default.
• W2616408378 type Work @default.
• W2616408378 sameAs 2616408378 @default.
• W2616408378 citedByCount "23" @default.
• W2616408378 countsByYear W26164083782018 @default.
• W2616408378 countsByYear W26164083782019 @default.
• W2616408378 countsByYear W26164083782020 @default.
• W2616408378 countsByYear W26164083782021 @default.
• W2616408378 countsByYear W26164083782022 @default.
• W2616408378 countsByYear W26164083782023 @default.
• W2616408378 crossrefType "journal-article" @default.
• W2616408378 hasAuthorship W2616408378A5012994303 @default.
• W2616408378 hasAuthorship W2616408378A5030566671 @default.
• W2616408378 hasAuthorship W2616408378A5044262695 @default.
• W2616408378 hasAuthorship W2616408378A5073577112 @default.
• W2616408378 hasAuthorship W2616408378A5073800945 @default.
• W2616408378 hasAuthorship W2616408378A5077844747 @default.
• W2616408378 hasAuthorship W2616408378A5080261804 @default.
• W2616408378 hasAuthorship W2616408378A5082717785 @default.
• W2616408378 hasAuthorship W2616408378A5082857119 @default.
• W2616408378 hasAuthorship W2616408378A5083220730 @default.
• W2616408378 hasBestOaLocation W26164083781 @default.
• W2616408378 hasConcept C126322002 @default.
• W2616408378 hasConcept C134018914 @default.
• W2616408378 hasConcept C170493617 @default.
• W2616408378 hasConcept C2775864247 @default.
• W2616408378 hasConcept C2775894120 @default.
• W2616408378 hasConcept C3018697912 @default.
• W2616408378 hasConcept C71924100 @default.
• W2616408378 hasConcept C89560881 @default.
• W2616408378 hasConceptScore W2616408378C126322002 @default.
• W2616408378 hasConceptScore W2616408378C134018914 @default.
• W2616408378 hasConceptScore W2616408378C170493617 @default.

• next