FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2616419215> ?p ?o ?g. }

• W2616419215 endingPage "2835" @default.
• W2616419215 startingPage "2827" @default.
• W2616419215 abstract "Human N-acetyltransferase 2 (NAT2) catalyzes the N-acetylation of numerous aromatic amine drugs such as sulfamethazine (SMZ) and hydrazine drugs such as isoniazid (INH). NAT2 also catalyzes the N-acetylation of aromatic amine carcinogens such as 2-aminofluorene and the O- and N,O-acetylation of aromatic amine and heterocyclic amine metabolites. Genetic polymorphism in NAT2 modifies drug efficacy and toxicity as well as cancer risk. Acetyltransferase catalytic activities and heat stability associated with six novel NAT2 haplotypes (NAT2*6C, NAT2*14C, NAT2*14D, NAT2*14E, NAT2*17, and NAT2*18) were compared with that of the reference NAT2*4 haplotype following recombinant expression in Escherichia coli. N-acetyltransferase activities towards SMZ and INH were significantly (p < 0.0001) lower when catalyzed by the novel recombinant human NAT2 allozymes compared to NAT2 4. SMZ and INH N-acetyltransferase activities catalyzed by NAT2 14C and NAT2 14D were significantly lower (p < 0.001) than catalyzed by NAT2 6C and NAT2 14E. N-Acetylation catalyzed by recombinant human NAT2 17 was over several hundred-fold lower than by recombinant NAT2 4 precluding measurement of its kinetic or heat inactivation constants. Similar results were observed for the O-acetylation of N-hydroxy-2-aminofluorene and N-hydroxy-2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine and the intramolecular N,O-acetylation of N-hydroxy-N-acetyl-2-aminofluorene. The apparent V max of the novel recombinant NAT2 allozymes NAT2 6C, NAT2 14C, NAT2 14D, and NAT2 14E towards AF, 4-aminobiphenyl (ABP), and 3,2'-dimethyl-4-aminobiphenyl (DMABP) were each significantly (p < 0.001) lower while their apparent K m values did not differ significantly (p > 0.05) from recombinant NAT2 4. The apparent V max catalyzed by NAT2 14C and NAT2 14D were significantly lower (p < 0.05) than the apparent V max catalyzed by NAT2 6C and NAT2 14E towards AF, ABP, and DMABP. Heat inactivation rate constants for recombinant human NAT2 14C, 14D, 14E, and 18 were significantly (p < 0.05) higher than NAT2 4. These results provide further evidence of genetic heterogeneity within the NAT2 slow acetylator phenotype." @default.
• W2616419215 created "2017-05-26" @default.
• W2616419215 creator A5014517451 @default.
• W2616419215 creator A5086028523 @default.
• W2616419215 date "2017-05-18" @default.
• W2616419215 modified "2023-09-26" @default.
• W2616419215 title "Catalytic properties and heat stabilities of novel recombinant human N-acetyltransferase 2 allozymes support existence of genetic heterogeneity within the slow acetylator phenotype" @default.
• W2616419215 cites W1906630699 @default.
• W2616419215 cites W1972316851 @default.
• W2616419215 cites W1975347866 @default.
• W2616419215 cites W1978494123 @default.
• W2616419215 cites W1984399473 @default.
• W2616419215 cites W1985232100 @default.
• W2616419215 cites W1988855705 @default.
• W2616419215 cites W1996151633 @default.
• W2616419215 cites W1998260637 @default.
• W2616419215 cites W2002957391 @default.
• W2616419215 cites W2008573798 @default.
• W2616419215 cites W2010914303 @default.
• W2616419215 cites W2027971820 @default.
• W2616419215 cites W2042503727 @default.
• W2616419215 cites W2042981474 @default.
• W2616419215 cites W2043064457 @default.
• W2616419215 cites W2052510996 @default.
• W2616419215 cites W2053867451 @default.
• W2616419215 cites W2060273330 @default.
• W2616419215 cites W2061203773 @default.
• W2616419215 cites W2072084995 @default.
• W2616419215 cites W2074093254 @default.
• W2616419215 cites W2077762449 @default.
• W2616419215 cites W2084527569 @default.
• W2616419215 cites W2088555055 @default.
• W2616419215 cites W2102433970 @default.
• W2616419215 cites W2106028933 @default.
• W2616419215 cites W2107165053 @default.
• W2616419215 cites W2115608456 @default.
• W2616419215 cites W2120913101 @default.
• W2616419215 cites W2123072231 @default.
• W2616419215 cites W2123904231 @default.
• W2616419215 cites W2128024417 @default.
• W2616419215 cites W2132772570 @default.
• W2616419215 cites W2138270253 @default.
• W2616419215 cites W2138629620 @default.
• W2616419215 cites W2142657810 @default.
• W2616419215 cites W2160882122 @default.
• W2616419215 cites W2168022936 @default.
• W2616419215 cites W2169207504 @default.
• W2616419215 cites W2177965561 @default.
• W2616419215 cites W2182950825 @default.
• W2616419215 cites W2287862604 @default.
• W2616419215 cites W2400308603 @default.
• W2616419215 cites W2615279325 @default.
• W2616419215 cites W2795876477 @default.
• W2616419215 doi "https://doi.org/10.1007/s00204-017-1989-7" @default.
• W2616419215 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5710007" @default.
• W2616419215 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28523442" @default.
• W2616419215 hasPublicationYear "2017" @default.
• W2616419215 type Work @default.
• W2616419215 sameAs 2616419215 @default.
• W2616419215 citedByCount "2" @default.
• W2616419215 countsByYear W26164192152020 @default.
• W2616419215 countsByYear W26164192152021 @default.
• W2616419215 crossrefType "journal-article" @default.
• W2616419215 hasAuthorship W2616419215A5014517451 @default.
• W2616419215 hasAuthorship W2616419215A5086028523 @default.
• W2616419215 hasBestOaLocation W26164192152 @default.
• W2616419215 hasConcept C104317684 @default.
• W2616419215 hasConcept C114246631 @default.
• W2616419215 hasConcept C119157956 @default.
• W2616419215 hasConcept C131779359 @default.
• W2616419215 hasConcept C178790620 @default.
• W2616419215 hasConcept C181199279 @default.
• W2616419215 hasConcept C185592680 @default.
• W2616419215 hasConcept C2777278644 @default.
• W2616419215 hasConcept C2778328694 @default.
• W2616419215 hasConcept C2778340702 @default.
• W2616419215 hasConcept C2779043668 @default.
• W2616419215 hasConcept C2779649592 @default.
• W2616419215 hasConcept C40767141 @default.
• W2616419215 hasConcept C55493867 @default.
• W2616419215 hasConcept C71240020 @default.
• W2616419215 hasConceptScore W2616419215C104317684 @default.
• W2616419215 hasConceptScore W2616419215C114246631 @default.
• W2616419215 hasConceptScore W2616419215C119157956 @default.
• W2616419215 hasConceptScore W2616419215C131779359 @default.
• W2616419215 hasConceptScore W2616419215C178790620 @default.
• W2616419215 hasConceptScore W2616419215C181199279 @default.
• W2616419215 hasConceptScore W2616419215C185592680 @default.
• W2616419215 hasConceptScore W2616419215C2777278644 @default.
• W2616419215 hasConceptScore W2616419215C2778328694 @default.
• W2616419215 hasConceptScore W2616419215C2778340702 @default.
• W2616419215 hasConceptScore W2616419215C2779043668 @default.
• W2616419215 hasConceptScore W2616419215C2779649592 @default.
• W2616419215 hasConceptScore W2616419215C40767141 @default.
• W2616419215 hasConceptScore W2616419215C55493867 @default.
• W2616419215 hasConceptScore W2616419215C71240020 @default.
• W2616419215 hasIssue "8" @default.
• W2616419215 hasLocation W26164192151 @default.

• next