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- W2616454571 abstract "Genetic variability greatly impacts on the human immune system and is the basis for inter-patient variability in alloimmune responses and allograft rejection. While human leukocyte antigen (HLA) polymorphism clearly has a dominant impact on the cellular immune response, we investigated if allelic sequence variation within T-cell receptor (TCR) loci represents another genetic variable influencing the T-cell alloresponse. Based on previous reports that some variable (V) gene polymorphisms encode for TCR regions that make contact with the peptide-HLA complex, a pyrosequencing technique was used to determine whether T-cells expressing certain TCR V gene alleles preferentially responded to HLA-mismatched stimulator cells. Frequently occurring polymorphisms within both TCR-α and -ß gene segments were shown to significantly influence T cell responsiveness to cells expressing a single mismatched HLA allele. The most striking bias was observed with TRAV8-7 and TRBV9, whereby individuals who were heterozygous for the two alleles responded to particular alloantigens with over 95% of T cells expressing only one of the alleles. Thus, polymorphism in the TCR loci is another genetic variable that may contribute toward inter-individual variability in T cell alloresponses and allograft rejection." @default.
- W2616454571 created "2017-05-26" @default.
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- W2616454571 date "2017-05-01" @default.
- W2616454571 modified "2023-09-26" @default.
- W2616454571 title "Allelic Polymorphism in the T-Cell Receptor Genes and Its Impact on T-Cell Alloreactivity" @default.
- W2616454571 doi "https://doi.org/10.1097/01.tp.0000520399.77215.56" @default.
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