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- W2616456253 abstract "Dissemination of breast cancer cells (BCCs) to distant sites (metastasis) is the ultimate cause of mortality in patients with breast cancer. Hypoxia (low O2) is a microenvironmental hallmark of most solid cancers arising as a mismatch between cellular O2 consumption and supply. Hypoxic selection of BCCs triggers molecular and cellular adaptations dependent upon hypoxia-inducible factors (HIFs), a family of evolutionarily conserved transcriptional activators that coordinate the expression of numerous genes controlling each step of the metastatic process. In this review, we summarize current advances in the understanding of HIF-driven molecular mechanisms that promote BCC metastatic dissemination and patient mortality. In addition, we discuss the clinical and therapeutic implications of HIF targeting in breast cancers." @default.
- W2616456253 created "2017-05-26" @default.
- W2616456253 creator A5031707961 @default.
- W2616456253 creator A5053927306 @default.
- W2616456253 date "2017-08-01" @default.
- W2616456253 modified "2023-10-16" @default.
- W2616456253 title "Hypoxic pathobiology of breast cancer metastasis" @default.
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