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- W2616506857 abstract "Background Antiresorptive drug related osteonecrosis of the jaw ( ARONJ ) can occur in patients taking bisphosphonates following an invasive dental procedure of the bone. At present, there is no accepted preventative intervention for the condition and its pathogenesis remains shrouded in mystery. Objectives The objective of this study was to elucidate if the application of a polyethylene glycol hydrogel with the addition of platelet-rich plasma (PRP) or recombinant human bone morphogenetic protein-2 (rhBMP-2) to a dentoalveolar socket could prevent the development of ARONJ in a pig animal model. Methods Three Australian minipigs (∼50 kg) were given weekly IV infusions of zoledronic acid (0.05 mg/kg) over eighteen weeks. Six weeks after the initial infusion the first premolars and first molars were removed surgically under general anaesthesia and defects homogenised to a volume of 785 mm3. The defects were then randomly assigned to a group and the interventions placed into the sockets. Defects were closed via a mucoperiosteal advancement flap and 4/0 Vicryl. After euthanasia the extraction sockets were harvested and processed for laboratory analysis. Findings Visually groups one and eight had necrosis with exposed bone present. Groups who received rhBMP-2 had the greatest mucosal closure. Laboratory analysis revealed statistically significant differences (P < 0.05) between the groups that received rhBMP-2 compared to groups one and eight in bone volume regenerated, osteoclastic and osteoblastic gene expression, and angiogenesis. Conclusions The application of a hydrogel or carrier with rhBMP-2 can stimulate increased angiogenesis and bone turnover in the local extraction socket environment. Further work is required to determine the minimum therapeutic dose of rhBMP-2 for ARONJ prevention." @default.
- W2616506857 created "2017-05-26" @default.
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- W2616506857 date "2017-03-01" @default.
- W2616506857 modified "2023-09-23" @default.
- W2616506857 title "A pilot study into prevention of antiresorptive drug-related osteonecrosis of the jaw in a porcine animal model" @default.
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