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- W2616572511 abstract "Aim: This study aims to validate the anti-Helicobacter pylori efficacy of amoxicillin-loaded nanoparticles and nanogels with pH-responsive and site-specific drug release properties against H. pylori infection. Materials & methods: Genipin-crosslinked low molecular weight fucoidan/chitosan-N-arginine nanogels (FCSA) were prepared for targeted delivery of amoxicillin to the site of H. pylori infected AGS gastric epithelial cells. Results: The negatively charged nanogels (n-FCSA) adhered to H. pylori and exhibited pH-responsive drug release property to reduce cytotoxic effects in H. pylori infected AGS cells. Conclusion: These in vitro findings suggest that n-FCSA nanogels are potential carriers for H. pylori specific delivery of antibacterial agents, and provide the basis for further studies on the clinical use of the nanogels." @default.
- W2616572511 created "2017-05-26" @default.
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- W2616572511 date "2017-06-01" @default.
- W2616572511 modified "2023-09-23" @default.
- W2616572511 title "Development of genipin-crosslinked fucoidan/chitosan-<i>N</i>-arginine nanogels for preventing <i>Helicobacter</i> infection" @default.
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- W2616572511 doi "https://doi.org/10.2217/nnm-2017-0055" @default.
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