FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2616574676> ?p ?o ?g. }

• W2616574676 abstract "Colorectal cancer (CRC) is the second leading cause of cancer-related death in men and women. Systemic disease with metastatic spread to distant sites such as the liver reduces the survival rate considerably. The aim of this study was to investigate the changes in gene expression that occur on invasion and expansion of CRC cells when forming metastases in the liver. The livers of syngeneic C57BL/6NCrl mice were inoculated with 1 million CRC cells (CMT-93) via the portal vein, leading to the stable formation of metastases within 4 weeks. RNA sequencing performed on the Illumina platform was employed to evaluate the expression profiles of more than 14,000 genes, utilizing the RNA of the cell line cells and liver metastases as well as from corresponding tumour-free liver. A total of 3329 differentially expressed genes (DEGs) were identified when cultured CMT-93 cells propagated as metastases in the liver. Hierarchical clustering on heat maps demonstrated the clear changes in gene expression of CMT-93 cells on propagation in the liver. Gene ontology analysis determined inflammation, angiogenesis, and signal transduction as the top three relevant biological processes involved. Using a selection list, matrix metallopeptidases 2, 7, and 9, wnt inhibitory factor, and chemokine receptor 4 were the top five significantly dysregulated genes. Bioinformatics assists in elucidating the factors and processes involved in CRC liver metastasis. Our results support the notion of an invasion-metastasis cascade involving CRC cells forming metastases on successful invasion and expansion within the liver. Furthermore, we identified a gene expression signature correlating strongly with invasiveness and migration. Our findings may guide future research on novel therapeutic targets in the treatment of CRC liver metastasis." @default.
• W2616574676 created "2017-05-26" @default.
• W2616574676 creator A5011726101 @default.
• W2616574676 creator A5017944645 @default.
• W2616574676 creator A5021851996 @default.
• W2616574676 creator A5024434468 @default.
• W2616574676 creator A5031452348 @default.
• W2616574676 creator A5035549647 @default.
• W2616574676 creator A5081552351 @default.
• W2616574676 creator A5089659190 @default.
• W2616574676 date "2017-05-19" @default.
• W2616574676 modified "2023-10-17" @default.
• W2616574676 title "The adaptation of colorectal cancer cells when forming metastases in the liver: expression of associated genes and pathways in a mouse model" @default.
• W2616574676 cites W1506680628 @default.
• W2616574676 cites W1520425169 @default.
• W2616574676 cites W1863581704 @default.
• W2616574676 cites W1953186510 @default.
• W2616574676 cites W1985727076 @default.
• W2616574676 cites W1988500653 @default.
• W2616574676 cites W1999574084 @default.
• W2616574676 cites W2003232455 @default.
• W2616574676 cites W2007040134 @default.
• W2616574676 cites W2007897263 @default.
• W2616574676 cites W2017104633 @default.
• W2616574676 cites W2025390110 @default.
• W2616574676 cites W2036182711 @default.
• W2616574676 cites W2053450932 @default.
• W2616574676 cites W2062265555 @default.
• W2616574676 cites W2069694547 @default.
• W2616574676 cites W2081046759 @default.
• W2616574676 cites W2087989448 @default.
• W2616574676 cites W2092868756 @default.
• W2616574676 cites W2093921289 @default.
• W2616574676 cites W2097705418 @default.
• W2616574676 cites W2101789878 @default.
• W2616574676 cites W2108009369 @default.
• W2616574676 cites W2111465076 @default.
• W2616574676 cites W2114104545 @default.
• W2616574676 cites W2120920534 @default.
• W2616574676 cites W2144744111 @default.
• W2616574676 cites W2148045801 @default.
• W2616574676 cites W2165146344 @default.
• W2616574676 cites W2165200432 @default.
• W2616574676 cites W2169456326 @default.
• W2616574676 cites W2169653318 @default.
• W2616574676 cites W2239828577 @default.
• W2616574676 cites W2310046094 @default.
• W2616574676 cites W2313029479 @default.
• W2616574676 cites W2389239223 @default.
• W2616574676 doi "https://doi.org/10.1186/s12885-017-3342-1" @default.
• W2616574676 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5437520" @default.
• W2616574676 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28525976" @default.
• W2616574676 hasPublicationYear "2017" @default.
• W2616574676 type Work @default.
• W2616574676 sameAs 2616574676 @default.
• W2616574676 citedByCount "9" @default.
• W2616574676 countsByYear W26165746762020 @default.
• W2616574676 countsByYear W26165746762021 @default.
• W2616574676 countsByYear W26165746762022 @default.
• W2616574676 countsByYear W26165746762023 @default.
• W2616574676 crossrefType "journal-article" @default.
• W2616574676 hasAuthorship W2616574676A5011726101 @default.
• W2616574676 hasAuthorship W2616574676A5017944645 @default.
• W2616574676 hasAuthorship W2616574676A5021851996 @default.
• W2616574676 hasAuthorship W2616574676A5024434468 @default.
• W2616574676 hasAuthorship W2616574676A5031452348 @default.
• W2616574676 hasAuthorship W2616574676A5035549647 @default.
• W2616574676 hasAuthorship W2616574676A5081552351 @default.
• W2616574676 hasAuthorship W2616574676A5089659190 @default.
• W2616574676 hasBestOaLocation W26165746761 @default.
• W2616574676 hasConcept C104317684 @default.
• W2616574676 hasConcept C121608353 @default.
• W2616574676 hasConcept C126322002 @default.
• W2616574676 hasConcept C137620995 @default.
• W2616574676 hasConcept C143998085 @default.
• W2616574676 hasConcept C150194340 @default.
• W2616574676 hasConcept C2776231280 @default.
• W2616574676 hasConcept C2778019345 @default.
• W2616574676 hasConcept C2779013556 @default.
• W2616574676 hasConcept C2780140570 @default.
• W2616574676 hasConcept C2780394083 @default.
• W2616574676 hasConcept C502942594 @default.
• W2616574676 hasConcept C526805850 @default.
• W2616574676 hasConcept C54355233 @default.
• W2616574676 hasConcept C71924100 @default.
• W2616574676 hasConcept C86803240 @default.
• W2616574676 hasConceptScore W2616574676C104317684 @default.
• W2616574676 hasConceptScore W2616574676C121608353 @default.
• W2616574676 hasConceptScore W2616574676C126322002 @default.
• W2616574676 hasConceptScore W2616574676C137620995 @default.
• W2616574676 hasConceptScore W2616574676C143998085 @default.
• W2616574676 hasConceptScore W2616574676C150194340 @default.
• W2616574676 hasConceptScore W2616574676C2776231280 @default.
• W2616574676 hasConceptScore W2616574676C2778019345 @default.
• W2616574676 hasConceptScore W2616574676C2779013556 @default.
• W2616574676 hasConceptScore W2616574676C2780140570 @default.
• W2616574676 hasConceptScore W2616574676C2780394083 @default.
• W2616574676 hasConceptScore W2616574676C502942594 @default.
• W2616574676 hasConceptScore W2616574676C526805850 @default.
• W2616574676 hasConceptScore W2616574676C54355233 @default.

• next