Matches in SemOpenAlex for { <https://semopenalex.org/work/W2616622385> ?p ?o ?g. }
- W2616622385 endingPage "6766" @default.
- W2616622385 startingPage "6762" @default.
- W2616622385 abstract "Pathogens frequently rely on lectins for adhesion and cellular entry into the host. Since these interactions typically result from multimeric binding of lectins to cell-surface glycans, novel therapeutic strategies are being developed with the use of glycomimetics as competitors of such interactions. Herein we study the benefit of nucleic acid based oligomeric assemblies with PNA-fucose conjugates. We demonstrate that the interactions of a lectin with epithelial cells can be inhibited with conjugates that do not form stable assemblies in solution but benefit from cooperativity between ligand-protein interactions and PNA hybridization to achieve high affinity. A dynamic dimeric assembly fully blocked the binding of the fucose-binding lectin BambL of Burkholderia ambifaria, a pathogenic bacterium, to epithelial cells with an efficiency of more than 700-fold compared to l-fucose." @default.
- W2616622385 created "2017-05-26" @default.
- W2616622385 creator A5001644478 @default.
- W2616622385 creator A5013419718 @default.
- W2616622385 creator A5023325095 @default.
- W2616622385 creator A5048363375 @default.
- W2616622385 creator A5053671693 @default.
- W2616622385 creator A5053836868 @default.
- W2616622385 creator A5060991744 @default.
- W2616622385 creator A5072318876 @default.
- W2616622385 creator A5083991053 @default.
- W2616622385 date "2017-05-15" @default.
- W2616622385 modified "2023-10-12" @default.
- W2616622385 title "Dynamic Cooperative Glycan Assembly Blocks the Binding of Bacterial Lectins to Epithelial Cells" @default.
- W2616622385 cites W1561759065 @default.
- W2616622385 cites W1763517808 @default.
- W2616622385 cites W1965243534 @default.
- W2616622385 cites W1974225228 @default.
- W2616622385 cites W1978208506 @default.
- W2616622385 cites W1979360726 @default.
- W2616622385 cites W1984305420 @default.
- W2616622385 cites W1993882494 @default.
- W2616622385 cites W2002609175 @default.
- W2616622385 cites W2003312569 @default.
- W2616622385 cites W2005124056 @default.
- W2616622385 cites W2011947123 @default.
- W2616622385 cites W2017694526 @default.
- W2616622385 cites W2035151448 @default.
- W2616622385 cites W2048426121 @default.
- W2616622385 cites W2079591167 @default.
- W2616622385 cites W2117974051 @default.
- W2616622385 cites W2122816122 @default.
- W2616622385 cites W2140248985 @default.
- W2616622385 cites W2144596898 @default.
- W2616622385 cites W2144875777 @default.
- W2616622385 cites W2145978352 @default.
- W2616622385 cites W2160752868 @default.
- W2616622385 cites W2315544017 @default.
- W2616622385 cites W2560551164 @default.
- W2616622385 cites W385760414 @default.
- W2616622385 cites W4233184616 @default.
- W2616622385 cites W4244015740 @default.
- W2616622385 cites W4246170175 @default.
- W2616622385 cites W4383497367 @default.
- W2616622385 doi "https://doi.org/10.1002/anie.201700813" @default.
- W2616622385 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28504473" @default.
- W2616622385 hasPublicationYear "2017" @default.
- W2616622385 type Work @default.
- W2616622385 sameAs 2616622385 @default.
- W2616622385 citedByCount "38" @default.
- W2616622385 countsByYear W26166223852017 @default.
- W2616622385 countsByYear W26166223852018 @default.
- W2616622385 countsByYear W26166223852019 @default.
- W2616622385 countsByYear W26166223852020 @default.
- W2616622385 countsByYear W26166223852021 @default.
- W2616622385 countsByYear W26166223852022 @default.
- W2616622385 countsByYear W26166223852023 @default.
- W2616622385 crossrefType "journal-article" @default.
- W2616622385 hasAuthorship W2616622385A5001644478 @default.
- W2616622385 hasAuthorship W2616622385A5013419718 @default.
- W2616622385 hasAuthorship W2616622385A5023325095 @default.
- W2616622385 hasAuthorship W2616622385A5048363375 @default.
- W2616622385 hasAuthorship W2616622385A5053671693 @default.
- W2616622385 hasAuthorship W2616622385A5053836868 @default.
- W2616622385 hasAuthorship W2616622385A5060991744 @default.
- W2616622385 hasAuthorship W2616622385A5072318876 @default.
- W2616622385 hasAuthorship W2616622385A5083991053 @default.
- W2616622385 hasBestOaLocation W26166223852 @default.
- W2616622385 hasConcept C108625454 @default.
- W2616622385 hasConcept C1491633281 @default.
- W2616622385 hasConcept C166014724 @default.
- W2616622385 hasConcept C185592680 @default.
- W2616622385 hasConcept C206212055 @default.
- W2616622385 hasConcept C24107716 @default.
- W2616622385 hasConcept C2776841590 @default.
- W2616622385 hasConcept C2780758401 @default.
- W2616622385 hasConcept C51639874 @default.
- W2616622385 hasConcept C55493867 @default.
- W2616622385 hasConcept C85789140 @default.
- W2616622385 hasConcept C86803240 @default.
- W2616622385 hasConcept C95444343 @default.
- W2616622385 hasConceptScore W2616622385C108625454 @default.
- W2616622385 hasConceptScore W2616622385C1491633281 @default.
- W2616622385 hasConceptScore W2616622385C166014724 @default.
- W2616622385 hasConceptScore W2616622385C185592680 @default.
- W2616622385 hasConceptScore W2616622385C206212055 @default.
- W2616622385 hasConceptScore W2616622385C24107716 @default.
- W2616622385 hasConceptScore W2616622385C2776841590 @default.
- W2616622385 hasConceptScore W2616622385C2780758401 @default.
- W2616622385 hasConceptScore W2616622385C51639874 @default.
- W2616622385 hasConceptScore W2616622385C55493867 @default.
- W2616622385 hasConceptScore W2616622385C85789140 @default.
- W2616622385 hasConceptScore W2616622385C86803240 @default.
- W2616622385 hasConceptScore W2616622385C95444343 @default.
- W2616622385 hasFunder F4320320883 @default.
- W2616622385 hasFunder F4320320924 @default.
- W2616622385 hasFunder F4320334678 @default.
- W2616622385 hasIssue "24" @default.