Matches in SemOpenAlex for { <https://semopenalex.org/work/W2616626780> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2616626780 endingPage "3249" @default.
- W2616626780 startingPage "3243" @default.
- W2616626780 abstract "Suppressors of cytokine signaling (SOCS) are encoded by immediate early genes known to inhibit cytokine responses in a classical feedback loop. SOCS gene expression has been shown to be induced by many cytokines, growth factors, and innate immune stimuli, such as LPS. In this paper, we report that the chemoattractants, IL-8 and fMLP, up-regulate SOCS1 mRNA in human myeloid cells, primary human neutrophils, PBMCs, and dendritic cells. fMLP rapidly up-regulates SOCS1, whereas the induction of SOCS1 upon IL-8 treatment is delayed. IL-8 and fMLP did not signal via Jak/STATs in primary human macrophages, thus implicating the induction of SOCS by other intracellular pathways. As chemoattractant-induced SOCS1 expression in neutrophils may play an important role in regulating the subsequent response to growth promoting cytokines like G-CSF, we investigated the effect of chemoattractant-induced SOCS1 on cytokine signal transduction. We show that pretreatment of primary human neutrophils with fMLP or IL-8 blocks G-CSF-mediated STAT3 activation. This study provides evidence for cross-talk between chemoattractant and cytokine signal transduction pathways involving SOCS proteins, suggesting that these chemotactic factors may desensitize neutrophils to G-CSF via rapid induction of SOCS1 expression." @default.
- W2616626780 created "2017-05-26" @default.
- W2616626780 creator A5006694562 @default.
- W2616626780 creator A5030142565 @default.
- W2616626780 creator A5036176344 @default.
- W2616626780 creator A5038296391 @default.
- W2616626780 creator A5040331730 @default.
- W2616626780 creator A5062748059 @default.
- W2616626780 creator A5071215739 @default.
- W2616626780 date "2004-09-01" @default.
- W2616626780 modified "2023-09-24" @default.
- W2616626780 title "The chemoattractants, IL-8 and formyl-methionyl-leucyl-phenylalanine, regulate granulocyte colony-stimulating factor signaling by inducing suppressor of cytokine signaling-1 expression" @default.
- W2616626780 hasPublicationYear "2004" @default.
- W2616626780 type Work @default.
- W2616626780 sameAs 2616626780 @default.
- W2616626780 citedByCount "0" @default.
- W2616626780 crossrefType "journal-article" @default.
- W2616626780 hasAuthorship W2616626780A5006694562 @default.
- W2616626780 hasAuthorship W2616626780A5030142565 @default.
- W2616626780 hasAuthorship W2616626780A5036176344 @default.
- W2616626780 hasAuthorship W2616626780A5038296391 @default.
- W2616626780 hasAuthorship W2616626780A5040331730 @default.
- W2616626780 hasAuthorship W2616626780A5062748059 @default.
- W2616626780 hasAuthorship W2616626780A5071215739 @default.
- W2616626780 hasConcept C104317684 @default.
- W2616626780 hasConcept C106363011 @default.
- W2616626780 hasConcept C126042315 @default.
- W2616626780 hasConcept C14077384 @default.
- W2616626780 hasConcept C150194340 @default.
- W2616626780 hasConcept C162354598 @default.
- W2616626780 hasConcept C170493617 @default.
- W2616626780 hasConcept C179185449 @default.
- W2616626780 hasConcept C203014093 @default.
- W2616626780 hasConcept C2778690821 @default.
- W2616626780 hasConcept C2778923194 @default.
- W2616626780 hasConcept C54166955 @default.
- W2616626780 hasConcept C55493867 @default.
- W2616626780 hasConcept C62478195 @default.
- W2616626780 hasConcept C84934515 @default.
- W2616626780 hasConcept C86803240 @default.
- W2616626780 hasConcept C95444343 @default.
- W2616626780 hasConceptScore W2616626780C104317684 @default.
- W2616626780 hasConceptScore W2616626780C106363011 @default.
- W2616626780 hasConceptScore W2616626780C126042315 @default.
- W2616626780 hasConceptScore W2616626780C14077384 @default.
- W2616626780 hasConceptScore W2616626780C150194340 @default.
- W2616626780 hasConceptScore W2616626780C162354598 @default.
- W2616626780 hasConceptScore W2616626780C170493617 @default.
- W2616626780 hasConceptScore W2616626780C179185449 @default.
- W2616626780 hasConceptScore W2616626780C203014093 @default.
- W2616626780 hasConceptScore W2616626780C2778690821 @default.
- W2616626780 hasConceptScore W2616626780C2778923194 @default.
- W2616626780 hasConceptScore W2616626780C54166955 @default.
- W2616626780 hasConceptScore W2616626780C55493867 @default.
- W2616626780 hasConceptScore W2616626780C62478195 @default.
- W2616626780 hasConceptScore W2616626780C84934515 @default.
- W2616626780 hasConceptScore W2616626780C86803240 @default.
- W2616626780 hasConceptScore W2616626780C95444343 @default.
- W2616626780 hasIssue "5" @default.
- W2616626780 hasLocation W26166267801 @default.
- W2616626780 hasOpenAccess W2616626780 @default.
- W2616626780 hasPrimaryLocation W26166267801 @default.
- W2616626780 hasRelatedWork W1510098359 @default.
- W2616626780 hasRelatedWork W1541744429 @default.
- W2616626780 hasRelatedWork W1776411292 @default.
- W2616626780 hasRelatedWork W1899067865 @default.
- W2616626780 hasRelatedWork W1983453191 @default.
- W2616626780 hasRelatedWork W2016313989 @default.
- W2616626780 hasRelatedWork W2017458586 @default.
- W2616626780 hasRelatedWork W2028273208 @default.
- W2616626780 hasRelatedWork W2038296012 @default.
- W2616626780 hasRelatedWork W2039615146 @default.
- W2616626780 hasRelatedWork W2048045422 @default.
- W2616626780 hasRelatedWork W2049349390 @default.
- W2616626780 hasRelatedWork W2062048006 @default.
- W2616626780 hasRelatedWork W2131728660 @default.
- W2616626780 hasRelatedWork W2515134560 @default.
- W2616626780 hasRelatedWork W2621233636 @default.
- W2616626780 hasRelatedWork W2780924514 @default.
- W2616626780 hasRelatedWork W2806848535 @default.
- W2616626780 hasRelatedWork W2903736981 @default.
- W2616626780 hasRelatedWork W2981231315 @default.
- W2616626780 isParatext "false" @default.
- W2616626780 isRetracted "false" @default.
- W2616626780 magId "2616626780" @default.
- W2616626780 workType "article" @default.