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• W2616647019 abstract "In a continuation of our research into antitubercular lanostane triterpenoids from submerged cultures of Ganoderma species, three strains, Ganoderma orbiforme BCC 22325, Ganoderma sp. BCC 60695, and Ganoderma australe BCC 22314, have been investigated. Fourteen new lanostane triterpenoids, together with 35 known compounds, were isolated. Antitubercular activities of these mycelium-associated Ganoderma lanostanoids against Mycobacterium tuberculosis H37Ra were evaluated. Taken together with the assay data of previously isolated compounds, structure-activity relationships of the antitubercular activity are proposed. Most importantly, 3β- and 15α-acetoxy groups were shown to be critical for antimycobacterial activity. The most potent compound was (24E)-3β,15α-diacetoxylanosta-7,9(11),24-trien-26-oic acid (35)." @default.
• W2616647019 created "2017-05-26" @default.
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• W2616647019 date "2017-05-15" @default.
• W2616647019 modified "2023-10-17" @default.
• W2616647019 title "Antitubercular Activity of Mycelium-Associated <i>Ganoderma</i> Lanostanoids" @default.
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• W2616647019 doi "https://doi.org/10.1021/acs.jnatprod.6b00973" @default.
• W2616647019 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28504879" @default.
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