FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2616678830> ?p ?o ?g. }

• W2616678830 endingPage "174" @default.
• W2616678830 startingPage "168" @default.
• W2616678830 abstract "The protective potential of ethyl pyruvate (EP) on neuron has been investigated previously. This study was intended to investigate the effects of EP on the severity of oxygen-glucose deprivation (OGD)-induced injury in neural-like PC12 cells. PC12 cells were exposed to OGD condition with or without EP treatment. Then, cell viability, apoptosis, and the expressions of neurotrophic factors were detected. Further, Sprague–Dawley rats were intravenously administered with 5 mg/kg EP for 14 days post-middle cerebral artery occlusion (MCAO). The effects of EP on the infarct volumes and neurological functions of MCAO rats were then assessed. Result showed that EP alleviated OGD-diminished cells viability, OGD-induced apoptosis, and OGD-reduced expressions of brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF) and Nestin in PC-12 cells. EP blocked OGD-activated the Notch1 and nuclear factor Kappa B (NF-κB) signaling pathways in PC12 cells. Besides, in vivo data demonstrated that EP treatment decreased infarct volume and mNSS score, and increased the time spent on the rota-rod apparatus of MCAO rats. To conclude, EP protected neural-like PC12 cells from cerebral ischemia–reperfusion injury by suppressing apoptosis and promoting neural restoration. Notch1 and NF-κB pathway might implicated in the functions of EP on neuron." @default.
• W2616678830 created "2017-05-26" @default.
• W2616678830 creator A5012486505 @default.
• W2616678830 creator A5045225444 @default.
• W2616678830 creator A5048843406 @default.
• W2616678830 creator A5056406981 @default.
• W2616678830 creator A5057206919 @default.
• W2616678830 creator A5067987105 @default.
• W2616678830 date "2017-08-01" @default.
• W2616678830 modified "2023-09-23" @default.
• W2616678830 title "Ethyl pyruvate protects PC12 cells from oxygen-glucose deprivation: A potential role in ischemic cerebrovascular disease" @default.
• W2616678830 cites W1522242377 @default.
• W2616678830 cites W1989690549 @default.
• W2616678830 cites W2002642158 @default.
• W2616678830 cites W2003023571 @default.
• W2616678830 cites W2019973536 @default.
• W2616678830 cites W2021183201 @default.
• W2616678830 cites W2032144770 @default.
• W2616678830 cites W2051303005 @default.
• W2616678830 cites W2051600135 @default.
• W2616678830 cites W2059606453 @default.
• W2616678830 cites W2071362026 @default.
• W2616678830 cites W2094211752 @default.
• W2616678830 cites W2096316414 @default.
• W2616678830 cites W2113145144 @default.
• W2616678830 cites W2119197080 @default.
• W2616678830 cites W2155838233 @default.
• W2616678830 cites W2157487737 @default.
• W2616678830 cites W2177410773 @default.
• W2616678830 cites W2289155891 @default.
• W2616678830 cites W2414406450 @default.
• W2616678830 cites W2417663854 @default.
• W2616678830 cites W2463268404 @default.
• W2616678830 cites W2483971647 @default.
• W2616678830 cites W2504956284 @default.
• W2616678830 cites W2507793541 @default.
• W2616678830 cites W2509853338 @default.
• W2616678830 cites W2513011130 @default.
• W2616678830 cites W2536771773 @default.
• W2616678830 cites W2589680782 @default.
• W2616678830 cites W334621809 @default.
• W2616678830 doi "https://doi.org/10.1016/j.biopha.2017.05.067" @default.
• W2616678830 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28538193" @default.
• W2616678830 hasPublicationYear "2017" @default.
• W2616678830 type Work @default.
• W2616678830 sameAs 2616678830 @default.
• W2616678830 citedByCount "8" @default.
• W2616678830 countsByYear W26166788302017 @default.
• W2616678830 countsByYear W26166788302018 @default.
• W2616678830 countsByYear W26166788302019 @default.
• W2616678830 countsByYear W26166788302020 @default.
• W2616678830 countsByYear W26166788302021 @default.
• W2616678830 crossrefType "journal-article" @default.
• W2616678830 hasAuthorship W2616678830A5012486505 @default.
• W2616678830 hasAuthorship W2616678830A5045225444 @default.
• W2616678830 hasAuthorship W2616678830A5048843406 @default.
• W2616678830 hasAuthorship W2616678830A5056406981 @default.
• W2616678830 hasAuthorship W2616678830A5057206919 @default.
• W2616678830 hasAuthorship W2616678830A5067987105 @default.
• W2616678830 hasConcept C126322002 @default.
• W2616678830 hasConcept C134018914 @default.
• W2616678830 hasConcept C136834591 @default.
• W2616678830 hasConcept C160539049 @default.
• W2616678830 hasConcept C170493617 @default.
• W2616678830 hasConcept C185592680 @default.
• W2616678830 hasConcept C190283241 @default.
• W2616678830 hasConcept C2777738006 @default.
• W2616678830 hasConcept C2778423431 @default.
• W2616678830 hasConcept C2778790584 @default.
• W2616678830 hasConcept C2780114680 @default.
• W2616678830 hasConcept C28328180 @default.
• W2616678830 hasConcept C53227056 @default.
• W2616678830 hasConcept C541997718 @default.
• W2616678830 hasConcept C55493867 @default.
• W2616678830 hasConcept C71924100 @default.
• W2616678830 hasConcept C86803240 @default.
• W2616678830 hasConcept C95444343 @default.
• W2616678830 hasConcept C98274493 @default.
• W2616678830 hasConceptScore W2616678830C126322002 @default.
• W2616678830 hasConceptScore W2616678830C134018914 @default.
• W2616678830 hasConceptScore W2616678830C136834591 @default.
• W2616678830 hasConceptScore W2616678830C160539049 @default.
• W2616678830 hasConceptScore W2616678830C170493617 @default.
• W2616678830 hasConceptScore W2616678830C185592680 @default.
• W2616678830 hasConceptScore W2616678830C190283241 @default.
• W2616678830 hasConceptScore W2616678830C2777738006 @default.
• W2616678830 hasConceptScore W2616678830C2778423431 @default.
• W2616678830 hasConceptScore W2616678830C2778790584 @default.
• W2616678830 hasConceptScore W2616678830C2780114680 @default.
• W2616678830 hasConceptScore W2616678830C28328180 @default.
• W2616678830 hasConceptScore W2616678830C53227056 @default.
• W2616678830 hasConceptScore W2616678830C541997718 @default.
• W2616678830 hasConceptScore W2616678830C55493867 @default.
• W2616678830 hasConceptScore W2616678830C71924100 @default.
• W2616678830 hasConceptScore W2616678830C86803240 @default.
• W2616678830 hasConceptScore W2616678830C95444343 @default.
• W2616678830 hasConceptScore W2616678830C98274493 @default.
• W2616678830 hasLocation W26166788301 @default.

• next