Matches in SemOpenAlex for { <https://semopenalex.org/work/W2616741311> ?p ?o ?g. }
- W2616741311 abstract "The Psmb11-encoded β5t subunit of the thymoproteasome, which is specifically expressed in cortical thymic epithelial cells (cTECs), is essential for the optimal positive selection of functionally competent CD8+ T cells in mice. Here, we report that a human genomic PSMB11 variation, which is detectable at an appreciable allele frequency in human populations, alters the β5t amino acid sequence that affects the processing of catalytically active β5t proteins. The introduction of this variation in the mouse genome revealed that the heterozygotes showed reduced β5t expression in cTECs and the homozygotes further exhibited reduction in the cellularity of CD8+ T cells. No severe health problems were noticed in many heterozygous and 5 homozygous human individuals. Long-term analysis of health status, particularly in the homozygotes, is expected to improve our understanding of the role of the thymoproteasome-dependent positive selection of CD8+ T cells in humans." @default.
- W2616741311 created "2017-05-26" @default.
- W2616741311 creator A5001318936 @default.
- W2616741311 creator A5002391399 @default.
- W2616741311 creator A5006787725 @default.
- W2616741311 creator A5009824094 @default.
- W2616741311 creator A5011477167 @default.
- W2616741311 creator A5013879304 @default.
- W2616741311 creator A5018182534 @default.
- W2616741311 creator A5020713654 @default.
- W2616741311 creator A5022448456 @default.
- W2616741311 creator A5025748633 @default.
- W2616741311 creator A5029891710 @default.
- W2616741311 creator A5029936292 @default.
- W2616741311 creator A5034140202 @default.
- W2616741311 creator A5034949085 @default.
- W2616741311 creator A5036273908 @default.
- W2616741311 creator A5040367383 @default.
- W2616741311 creator A5042371436 @default.
- W2616741311 creator A5042787337 @default.
- W2616741311 creator A5044722698 @default.
- W2616741311 creator A5059658283 @default.
- W2616741311 creator A5075475154 @default.
- W2616741311 creator A5082187394 @default.
- W2616741311 creator A5086413249 @default.
- W2616741311 date "2017-05-18" @default.
- W2616741311 modified "2023-10-16" @default.
- W2616741311 title "A human PSMB11 variant affects thymoproteasome processing and CD8+ T cell production" @default.
- W2616741311 cites W1617046568 @default.
- W2616741311 cites W17552899 @default.
- W2616741311 cites W1967399128 @default.
- W2616741311 cites W1972160020 @default.
- W2616741311 cites W1986568390 @default.
- W2616741311 cites W1993201799 @default.
- W2616741311 cites W2004699309 @default.
- W2616741311 cites W2011833868 @default.
- W2616741311 cites W2017082201 @default.
- W2616741311 cites W2024748688 @default.
- W2616741311 cites W2026614040 @default.
- W2616741311 cites W2027007610 @default.
- W2616741311 cites W2028135910 @default.
- W2616741311 cites W2028703847 @default.
- W2616741311 cites W2050625211 @default.
- W2616741311 cites W2053071361 @default.
- W2616741311 cites W2056730836 @default.
- W2616741311 cites W2058171547 @default.
- W2616741311 cites W2078280637 @default.
- W2616741311 cites W2085354593 @default.
- W2616741311 cites W2093191258 @default.
- W2616741311 cites W2094751071 @default.
- W2616741311 cites W2114667045 @default.
- W2616741311 cites W2122264691 @default.
- W2616741311 cites W2126391194 @default.
- W2616741311 cites W2130960197 @default.
- W2616741311 cites W2154820739 @default.
- W2616741311 cites W2167380395 @default.
- W2616741311 cites W2202471025 @default.
- W2616741311 cites W2203448 @default.
- W2616741311 cites W2525401066 @default.
- W2616741311 cites W2566426804 @default.
- W2616741311 cites W2583176331 @default.
- W2616741311 doi "https://doi.org/10.1172/jci.insight.93664" @default.
- W2616741311 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5436549" @default.
- W2616741311 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28515360" @default.
- W2616741311 hasPublicationYear "2017" @default.
- W2616741311 type Work @default.
- W2616741311 sameAs 2616741311 @default.
- W2616741311 citedByCount "6" @default.
- W2616741311 countsByYear W26167413112018 @default.
- W2616741311 countsByYear W26167413112020 @default.
- W2616741311 countsByYear W26167413112021 @default.
- W2616741311 crossrefType "journal-article" @default.
- W2616741311 hasAuthorship W2616741311A5001318936 @default.
- W2616741311 hasAuthorship W2616741311A5002391399 @default.
- W2616741311 hasAuthorship W2616741311A5006787725 @default.
- W2616741311 hasAuthorship W2616741311A5009824094 @default.
- W2616741311 hasAuthorship W2616741311A5011477167 @default.
- W2616741311 hasAuthorship W2616741311A5013879304 @default.
- W2616741311 hasAuthorship W2616741311A5018182534 @default.
- W2616741311 hasAuthorship W2616741311A5020713654 @default.
- W2616741311 hasAuthorship W2616741311A5022448456 @default.
- W2616741311 hasAuthorship W2616741311A5025748633 @default.
- W2616741311 hasAuthorship W2616741311A5029891710 @default.
- W2616741311 hasAuthorship W2616741311A5029936292 @default.
- W2616741311 hasAuthorship W2616741311A5034140202 @default.
- W2616741311 hasAuthorship W2616741311A5034949085 @default.
- W2616741311 hasAuthorship W2616741311A5036273908 @default.
- W2616741311 hasAuthorship W2616741311A5040367383 @default.
- W2616741311 hasAuthorship W2616741311A5042371436 @default.
- W2616741311 hasAuthorship W2616741311A5042787337 @default.
- W2616741311 hasAuthorship W2616741311A5044722698 @default.
- W2616741311 hasAuthorship W2616741311A5059658283 @default.
- W2616741311 hasAuthorship W2616741311A5075475154 @default.
- W2616741311 hasAuthorship W2616741311A5082187394 @default.
- W2616741311 hasAuthorship W2616741311A5086413249 @default.
- W2616741311 hasBestOaLocation W26167413111 @default.
- W2616741311 hasConcept C104292427 @default.
- W2616741311 hasConcept C104317684 @default.
- W2616741311 hasConcept C141231307 @default.
- W2616741311 hasConcept C153471976 @default.