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• W2616746657 abstract "We have recently reported that the serotonin (5-HT) projections from the midbrain’s raphe nuclei that contains 5-HT cell bodies may play a role both in heat production and in heat loss. The purpose of the present study was to clarify the involvement of 5-HT in the ventral tegmental area (VTA), where 5-HT is suggested to participate in thermoregulation, using the combined methods of telemetry, microdialysis, and high performance liquid chromatography, with a special emphasis on regulation of the body temperature (Tb) in freely moving rats. First, we measured changes in Tb, tail skin temperature (Ttail; an index of heat loss), heart rate (HR; an index of heat production), locomotor activity (Act), and levels of extracellular monoamines in the VTA during cold (5 °C) or heat (35 °C) exposure. Subsequently, we perfused citalopram (5-HT re-uptake inhibitor) into the VTA and measured the thermoregulatory parameters and monoamines release. Although Tb, Ttail, and HR changed during both exposures, significant changes in extracellular level of 5-HT (138.7 ± 12.7% baseline, p < 0.01), but not dopamine (DA) or noradrenaline (NA) were noted in the VTA only during heat exposure. In addition, perfusion of citalopram into the VTA increased extracellular 5-HT levels (221.0 ± 52.2% baseline, p < 0.01), but not DA or NA, while Tb decreased from 37.4 ± 0.1 °C to 36.8 ± 0.2 °C (p < 0.001), Ttail increased from 26.3 ± 0.4 °C to 28.4 ± 0.4 °C (p < 0.001), and HR and Act remained unchanged. Our results suggest that the VTA is a key area for thermoregulation, and 5-HT, but not DA or NA, modulates the heat loss system through action in the VTA." @default.
• W2616746657 created "2017-05-26" @default.
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• W2616746657 date "2017-07-01" @default.
• W2616746657 modified "2023-10-18" @default.
• W2616746657 title "Involvement of serotonin in the ventral tegmental area in thermoregulation of freely moving rats" @default.
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• W2616746657 doi "https://doi.org/10.1016/j.neulet.2017.05.030" @default.
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