Matches in SemOpenAlex for { <https://semopenalex.org/work/W2616759563> ?p ?o ?g. }
- W2616759563 endingPage "12" @default.
- W2616759563 startingPage "1" @default.
- W2616759563 abstract "Exosomes secreted by mesenchymal stem cells (MSCs) have shown repairing effects on several tissue injury diseases. In this study, we aimed to investigate the effects of exosomes released from human umbilical cord mesenchymal stem cells (hucMSCs) on the treatment of dextran sulfate sodium- (DSS-) induced inflammatory bowel disease (IBD) and to explore the underlying mechanism. We found that indocyanine green (ICG) labeled exosomes homed to colon tissues of IBD mice at 12 hours after injection. Exosomes significantly relieved the severity of IBD in mice as hucMSCs. The expression of IL-10 gene was increased while that of TNF- α , IL-1 β , IL-6, iNOS, and IL-7 genes was decreased in the colon tissues and spleens of exosomes-treated mice. Furthermore, the infiltration of macrophages into the colon tissues was decreased by exosome treatment in IBD mice. In addition, we provided evidence that in vitro coculture with exosomes inhibited the expression of iNOS and IL-7 in mouse enterocoelia macrophages. Moreover, we found that the expression of IL-7 was higher in the colon tissues of colitis patients than that of healthy controls. Our findings suggest that exosomes from hucMSCs have profound effects on alleviating DSS-induced IBD and may exert their impact through the modulation of IL-7 expression in macrophages." @default.
- W2616759563 created "2017-05-26" @default.
- W2616759563 creator A5027924175 @default.
- W2616759563 creator A5041277132 @default.
- W2616759563 creator A5046881277 @default.
- W2616759563 creator A5048965407 @default.
- W2616759563 creator A5051242165 @default.
- W2616759563 creator A5067238930 @default.
- W2616759563 creator A5069598030 @default.
- W2616759563 creator A5071329338 @default.
- W2616759563 creator A5073568638 @default.
- W2616759563 date "2017-01-01" @default.
- W2616759563 modified "2023-10-17" @default.
- W2616759563 title "Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Relieve Inflammatory Bowel Disease in Mice" @default.
- W2616759563 cites W1553048017 @default.
- W2616759563 cites W1601173130 @default.
- W2616759563 cites W1969119774 @default.
- W2616759563 cites W1990341849 @default.
- W2616759563 cites W1990950572 @default.
- W2616759563 cites W2009567356 @default.
- W2616759563 cites W2011508825 @default.
- W2616759563 cites W2019495971 @default.
- W2616759563 cites W2022042576 @default.
- W2616759563 cites W2025447206 @default.
- W2616759563 cites W2030491651 @default.
- W2616759563 cites W2043263890 @default.
- W2616759563 cites W2045080708 @default.
- W2616759563 cites W2045475041 @default.
- W2616759563 cites W2046026467 @default.
- W2616759563 cites W2046985281 @default.
- W2616759563 cites W2049897663 @default.
- W2616759563 cites W2055424631 @default.
- W2616759563 cites W2058812990 @default.
- W2616759563 cites W2058907132 @default.
- W2616759563 cites W2074218230 @default.
- W2616759563 cites W2075889321 @default.
- W2616759563 cites W2091526175 @default.
- W2616759563 cites W2099369804 @default.
- W2616759563 cites W2108541168 @default.
- W2616759563 cites W2115508261 @default.
- W2616759563 cites W2124124073 @default.
- W2616759563 cites W2130794824 @default.
- W2616759563 cites W2136611420 @default.
- W2616759563 cites W2141720233 @default.
- W2616759563 cites W2145142940 @default.
- W2616759563 cites W2147923982 @default.
- W2616759563 cites W2159999899 @default.
- W2616759563 cites W2257130060 @default.
- W2616759563 cites W2262985044 @default.
- W2616759563 cites W2287440804 @default.
- W2616759563 cites W2326463211 @default.
- W2616759563 cites W2342859699 @default.
- W2616759563 cites W2396322679 @default.
- W2616759563 cites W2398917510 @default.
- W2616759563 cites W2412721688 @default.
- W2616759563 cites W2413758166 @default.
- W2616759563 cites W2433617566 @default.
- W2616759563 cites W2509179509 @default.
- W2616759563 cites W2538370262 @default.
- W2616759563 cites W2567035970 @default.
- W2616759563 cites W2571034953 @default.
- W2616759563 cites W31665177 @default.
- W2616759563 cites W4390753 @default.
- W2616759563 doi "https://doi.org/10.1155/2017/5356760" @default.
- W2616759563 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5447283" @default.
- W2616759563 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28589143" @default.
- W2616759563 hasPublicationYear "2017" @default.
- W2616759563 type Work @default.
- W2616759563 sameAs 2616759563 @default.
- W2616759563 citedByCount "142" @default.
- W2616759563 countsByYear W26167595632017 @default.
- W2616759563 countsByYear W26167595632018 @default.
- W2616759563 countsByYear W26167595632019 @default.
- W2616759563 countsByYear W26167595632020 @default.
- W2616759563 countsByYear W26167595632021 @default.
- W2616759563 countsByYear W26167595632022 @default.
- W2616759563 countsByYear W26167595632023 @default.
- W2616759563 crossrefType "journal-article" @default.
- W2616759563 hasAuthorship W2616759563A5027924175 @default.
- W2616759563 hasAuthorship W2616759563A5041277132 @default.
- W2616759563 hasAuthorship W2616759563A5046881277 @default.
- W2616759563 hasAuthorship W2616759563A5048965407 @default.
- W2616759563 hasAuthorship W2616759563A5051242165 @default.
- W2616759563 hasAuthorship W2616759563A5067238930 @default.
- W2616759563 hasAuthorship W2616759563A5069598030 @default.
- W2616759563 hasAuthorship W2616759563A5071329338 @default.
- W2616759563 hasAuthorship W2616759563A5073568638 @default.
- W2616759563 hasBestOaLocation W26167595631 @default.
- W2616759563 hasConcept C104317684 @default.
- W2616759563 hasConcept C142724271 @default.
- W2616759563 hasConcept C145059251 @default.
- W2616759563 hasConcept C164027704 @default.
- W2616759563 hasConcept C198826908 @default.
- W2616759563 hasConcept C203014093 @default.
- W2616759563 hasConcept C20518536 @default.
- W2616759563 hasConcept C2776914184 @default.
- W2616759563 hasConcept C2776955114 @default.
- W2616759563 hasConcept C2778260677 @default.