FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2616803923> ?p ?o ?g. }

• W2616803923 abstract "Angiopoietin-2 (Ang-2) has been investigated in cancer primarily in terms of its angiogenic function, and its role as an oncogene has yet to be elucidated. The current study hypothesized that Ang-2 may be an oncogene and have a function in tumor progression. An investigation of the function of Ang-2 in the LoVo colorectal cancer (CRC) cell line in vitro, which expresses a high level of Ang-2, was performed by knocking down endogenous expression with a targeted short hairpin RNA. The aggressive phenotypic effects of Ang-2 on experimental and control group cells were assessed using cell proliferation, migration and invasion assays. The association between Ang-2 expression levels and clinicopathological factors was evaluated in 415 CRC tissues using immunohistochemistry. Suppressing Ang-2 expression decreased cellular proliferation, invasion and migration in an in vitro study. Ang-2 overexpression was observed in 46% of patients with CRC and was significantly associated with pT (P=0.048), pN (P<0.001), venous invasion (P=0.023), lymphatic invasion (P<0.001) and tumor-node-metastasis stage (P=0.022). Furthermore, Ang-2 overexpression was an independent prognostic factor in pN stages 1 and 2. These results reveal that Ang-2 may be an oncogene in colorectal carcinogenesis and its expression may exert aggressive phenotypic effects during tumor progression. In addition, Ang-2 expression may serve as a prognostic marker and a potential drug target." @default.
• W2616803923 created "2017-05-26" @default.
• W2616803923 creator A5005196912 @default.
• W2616803923 creator A5006696982 @default.
• W2616803923 creator A5008421230 @default.
• W2616803923 creator A5016254699 @default.
• W2616803923 creator A5023107984 @default.
• W2616803923 creator A5025416763 @default.
• W2616803923 creator A5036729023 @default.
• W2616803923 creator A5055100242 @default.
• W2616803923 creator A5057913923 @default.
• W2616803923 creator A5068809063 @default.
• W2616803923 creator A5070856229 @default.
• W2616803923 creator A5075150288 @default.
• W2616803923 creator A5086036131 @default.
• W2616803923 date "2017-05-18" @default.
• W2616803923 modified "2023-09-27" @default.
• W2616803923 title "Oncogenic function of angiopoietin-2 in vitro and its modulation of tumor progression in colorectal carcinoma" @default.
• W2616803923 cites W109317992 @default.
• W2616803923 cites W1498167302 @default.
• W2616803923 cites W1573363574 @default.
• W2616803923 cites W1576660283 @default.
• W2616803923 cites W1783580437 @default.
• W2616803923 cites W1968293112 @default.
• W2616803923 cites W1982613163 @default.
• W2616803923 cites W1985500381 @default.
• W2616803923 cites W2014245338 @default.
• W2616803923 cites W2029658107 @default.
• W2616803923 cites W2038233531 @default.
• W2616803923 cites W2043103956 @default.
• W2616803923 cites W2043228552 @default.
• W2616803923 cites W2055220513 @default.
• W2616803923 cites W2065242375 @default.
• W2616803923 cites W2085054303 @default.
• W2616803923 cites W2086435807 @default.
• W2616803923 cites W2087256879 @default.
• W2616803923 cites W2136405754 @default.
• W2616803923 cites W2137596113 @default.
• W2616803923 cites W2140080261 @default.
• W2616803923 cites W2145267522 @default.
• W2616803923 cites W2150487692 @default.
• W2616803923 cites W2152740887 @default.
• W2616803923 cites W2159755902 @default.
• W2616803923 cites W2170201138 @default.
• W2616803923 cites W2170770755 @default.
• W2616803923 cites W2916719214 @default.
• W2616803923 cites W3147439379 @default.
• W2616803923 doi "https://doi.org/10.3892/ol.2017.6203" @default.
• W2616803923 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5494651" @default.
• W2616803923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28693205" @default.
• W2616803923 hasPublicationYear "2017" @default.
• W2616803923 type Work @default.
• W2616803923 sameAs 2616803923 @default.
• W2616803923 citedByCount "4" @default.
• W2616803923 countsByYear W26168039232020 @default.
• W2616803923 countsByYear W26168039232021 @default.
• W2616803923 countsByYear W26168039232022 @default.
• W2616803923 crossrefType "journal-article" @default.
• W2616803923 hasAuthorship W2616803923A5005196912 @default.
• W2616803923 hasAuthorship W2616803923A5006696982 @default.
• W2616803923 hasAuthorship W2616803923A5008421230 @default.
• W2616803923 hasAuthorship W2616803923A5016254699 @default.
• W2616803923 hasAuthorship W2616803923A5023107984 @default.
• W2616803923 hasAuthorship W2616803923A5025416763 @default.
• W2616803923 hasAuthorship W2616803923A5036729023 @default.
• W2616803923 hasAuthorship W2616803923A5055100242 @default.
• W2616803923 hasAuthorship W2616803923A5057913923 @default.
• W2616803923 hasAuthorship W2616803923A5068809063 @default.
• W2616803923 hasAuthorship W2616803923A5070856229 @default.
• W2616803923 hasAuthorship W2616803923A5075150288 @default.
• W2616803923 hasAuthorship W2616803923A5086036131 @default.
• W2616803923 hasBestOaLocation W26168039231 @default.
• W2616803923 hasConcept C121608353 @default.
• W2616803923 hasConcept C126322002 @default.
• W2616803923 hasConcept C203014093 @default.
• W2616803923 hasConcept C204232928 @default.
• W2616803923 hasConcept C2778740770 @default.
• W2616803923 hasConcept C2779013556 @default.
• W2616803923 hasConcept C2779256057 @default.
• W2616803923 hasConcept C2780394083 @default.
• W2616803923 hasConcept C2781018059 @default.
• W2616803923 hasConcept C29537977 @default.
• W2616803923 hasConcept C502942594 @default.
• W2616803923 hasConcept C526805850 @default.
• W2616803923 hasConcept C54355233 @default.
• W2616803923 hasConcept C555283112 @default.
• W2616803923 hasConcept C62112901 @default.
• W2616803923 hasConcept C67082663 @default.
• W2616803923 hasConcept C71924100 @default.
• W2616803923 hasConcept C86803240 @default.
• W2616803923 hasConceptScore W2616803923C121608353 @default.
• W2616803923 hasConceptScore W2616803923C126322002 @default.
• W2616803923 hasConceptScore W2616803923C203014093 @default.
• W2616803923 hasConceptScore W2616803923C204232928 @default.
• W2616803923 hasConceptScore W2616803923C2778740770 @default.
• W2616803923 hasConceptScore W2616803923C2779013556 @default.
• W2616803923 hasConceptScore W2616803923C2779256057 @default.
• W2616803923 hasConceptScore W2616803923C2780394083 @default.
• W2616803923 hasConceptScore W2616803923C2781018059 @default.
• W2616803923 hasConceptScore W2616803923C29537977 @default.

• next