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• W2616805871 endingPage "789" @default.
• W2616805871 startingPage "782" @default.
• W2616805871 abstract "Phytomedicine research received tremendous attention for novel therapeutic agent due to their safety and low cost. We assessed a novel nanoformulation of Biophytum sensitivum (BS), natural flavonoids for their improved efficacy and superior bioavailability against crude extract for prostate cancer cells (PC3). We prepared a nanomedicine of BS by nanoprecipitation method and size analysis via DLS and SEM revealed a range of 100–118 nm and surface zeta potential as −9.77 mV. FTIR was performed to evaluate functional for presence of carbonyl and aromatic rings, respectively. Human PC3 cells showed concentration at 0.5, 0.8, and 1 mg/ml dependent cytotoxicity 22, 39, and 56% for 24 h, whereas 43, 41, and 67% for 48 h of BS nanomedicine compared with crude 11, 22, and 53% for 24 h and 38, 31, and 60% for 48 h, respectively. Haemocompatibility of BS nanomedicine at the concentration of 0.5, 0.8, and 1 mg/ml did not show blood aggregation. Cellular uptake was confirmed using rhodamine-conjugated BS nanomedicine for 48 h. Interestingly, BS nanomedicine 1 mg/ml decreases the nitrite productions in PC3 cells. Collectively, BS nanomedicine has the potential anti-cancer agents with biocompatible and enhanced efficacy can be beneficial for the treatment of prostate cancer" @default.
• W2616805871 created "2017-05-26" @default.
• W2616805871 creator A5015945024 @default.
• W2616805871 creator A5051340124 @default.
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• W2616805871 date "2017-08-02" @default.
• W2616805871 modified "2023-10-18" @default.
• W2616805871 title "Biophytum sensitivum nanomedicine reduces cell viability and nitrite production in prostate cancer cells" @default.
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• W2616805871 doi "https://doi.org/10.1049/iet-nbt.2016.0235" @default.
• W2616805871 hasPublicationYear "2017" @default.
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