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• W2616882914 startingPage "1135" @default.
• W2616882914 abstract "Influenza A viruses remain a significant health problem, especially when a novel subtype emerges from the avian population to cause severe outbreaks in humans. Zoonotic viruses arise from the animal population as a result of mutations and reassortments, giving rise to novel strains with the capability to evade the host species barrier and cause human infections. Despite progress in understanding interspecies transmission of influenza viruses, we are no closer to predicting zoonotic strains that can lead to an outbreak. We have previously discovered distinct host tropism protein signatures of avian, human and zoonotic influenza strains obtained from host tropism predictions on individual protein sequences. Here, we apply machine learning approaches on the signatures to build a computational model capable of predicting zoonotic strains. The zoonotic strain prediction model can classify avian, human or zoonotic strains with high accuracy, as well as providing an estimated zoonotic risk. This would therefore allow us to quickly determine if an influenza virus strain has the potential to be zoonotic using only protein sequences. The swift identification of potential zoonotic strains in the animal population using the zoonotic strain prediction model could provide us with an early indication of an imminent influenza outbreak." @default.
• W2616882914 created "2017-06-05" @default.
• W2616882914 creator A5008594188 @default.
• W2616882914 creator A5028617489 @default.
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• W2616882914 date "2017-05-25" @default.
• W2616882914 modified "2023-10-01" @default.
• W2616882914 title "Predicting Zoonotic Risk of Influenza A Viruses from Host Tropism Protein Signature Using Random Forest" @default.
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• W2616882914 doi "https://doi.org/10.3390/ijms18061135" @default.
• W2616882914 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5485959" @default.
• W2616882914 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28587080" @default.
• W2616882914 hasPublicationYear "2017" @default.
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