FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2616890438> ?p ?o ?g. }

• W2616890438 abstract "Gingerol is a major dietary compound that occurs in several plants belonging to the Zingiberaceae family. In the current study, the protective effect of gingerol on STZ-induced sporadic Alzheimer's disease (SAD) was determined. Gingerol was isolated from the seeds of Aframomum melegueta K. Schum and tested at doses of 10 and 20 mg/kgbwt for its possible effect on the SAD model in mice, using celecoxib (30 mg/kg bwt) as a reference standard. The curative effects of gingerol were assessed through measurement of β-amyloid (Aβ-42), α-, β- secretases, APH1a and COX-2 levels. In addition, improvement in the cognitive deficit in mice after treatment was confirmed using the water maze and Y-maze with intra-maze cues. Gingerol improved the cognitive and behavioral impairment and AD-like pathology in streptozotocin model mice. These beneficial effects occurred with an increase in α-secretase activity and a decrease in cerebral Aβ-42, β- secretase, APH1a activity and COX-2-linked neuro-inflammation." @default.
• W2616890438 created "2017-06-05" @default.
• W2616890438 creator A5047052632 @default.
• W2616890438 creator A5051362040 @default.
• W2616890438 creator A5067258065 @default.
• W2616890438 creator A5079774265 @default.
• W2616890438 date "2017-06-06" @default.
• W2616890438 modified "2023-10-05" @default.
• W2616890438 title "Protective effects of gingerol on streptozotocin-induced sporadic Alzheimer’s disease: emphasis on inhibition of β-amyloid, COX-2, alpha-, beta - secretases and APH1a" @default.
• W2616890438 cites W1487675939 @default.
• W2616890438 cites W1487727801 @default.
• W2616890438 cites W1595531455 @default.
• W2616890438 cites W1670803694 @default.
• W2616890438 cites W1833368592 @default.
• W2616890438 cites W1977451682 @default.
• W2616890438 cites W1978494744 @default.
• W2616890438 cites W1979787441 @default.
• W2616890438 cites W1983014483 @default.
• W2616890438 cites W1992123323 @default.
• W2616890438 cites W1993377197 @default.
• W2616890438 cites W2000075444 @default.
• W2616890438 cites W2004738728 @default.
• W2616890438 cites W2012327371 @default.
• W2616890438 cites W2017779103 @default.
• W2616890438 cites W2028557451 @default.
• W2616890438 cites W2032006844 @default.
• W2616890438 cites W2035092856 @default.
• W2616890438 cites W2035778488 @default.
• W2616890438 cites W2037520593 @default.
• W2616890438 cites W2038488950 @default.
• W2616890438 cites W2039428198 @default.
• W2616890438 cites W2039755830 @default.
• W2616890438 cites W2041508562 @default.
• W2616890438 cites W2044987522 @default.
• W2616890438 cites W2071263424 @default.
• W2616890438 cites W2080238811 @default.
• W2616890438 cites W2081093364 @default.
• W2616890438 cites W2090552566 @default.
• W2616890438 cites W2109119080 @default.
• W2616890438 cites W2112138262 @default.
• W2616890438 cites W2119445810 @default.
• W2616890438 cites W2124434575 @default.
• W2616890438 cites W2128860352 @default.
• W2616890438 cites W2131059456 @default.
• W2616890438 cites W2154508412 @default.
• W2616890438 cites W2159879659 @default.
• W2616890438 cites W2164317658 @default.
• W2616890438 cites W2169473035 @default.
• W2616890438 cites W2189066799 @default.
• W2616890438 cites W2317522265 @default.
• W2616890438 cites W4247759744 @default.
• W2616890438 doi "https://doi.org/10.1038/s41598-017-02961-0" @default.
• W2616890438 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5460182" @default.
• W2616890438 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28588301" @default.
• W2616890438 hasPublicationYear "2017" @default.
• W2616890438 type Work @default.
• W2616890438 sameAs 2616890438 @default.
• W2616890438 citedByCount "72" @default.
• W2616890438 countsByYear W26168904382017 @default.
• W2616890438 countsByYear W26168904382018 @default.
• W2616890438 countsByYear W26168904382019 @default.
• W2616890438 countsByYear W26168904382020 @default.
• W2616890438 countsByYear W26168904382021 @default.
• W2616890438 countsByYear W26168904382022 @default.
• W2616890438 countsByYear W26168904382023 @default.
• W2616890438 crossrefType "journal-article" @default.
• W2616890438 hasAuthorship W2616890438A5047052632 @default.
• W2616890438 hasAuthorship W2616890438A5051362040 @default.
• W2616890438 hasAuthorship W2616890438A5067258065 @default.
• W2616890438 hasAuthorship W2616890438A5079774265 @default.
• W2616890438 hasBestOaLocation W26168904381 @default.
• W2616890438 hasConcept C126322002 @default.
• W2616890438 hasConcept C134018914 @default.
• W2616890438 hasConcept C134550120 @default.
• W2616890438 hasConcept C2776156579 @default.
• W2616890438 hasConcept C2776789170 @default.
• W2616890438 hasConcept C2779134260 @default.
• W2616890438 hasConcept C2779280383 @default.
• W2616890438 hasConcept C31705614 @default.
• W2616890438 hasConcept C36103677 @default.
• W2616890438 hasConcept C502032728 @default.
• W2616890438 hasConcept C555293320 @default.
• W2616890438 hasConcept C556039675 @default.
• W2616890438 hasConcept C71924100 @default.
• W2616890438 hasConcept C98274493 @default.
• W2616890438 hasConceptScore W2616890438C126322002 @default.
• W2616890438 hasConceptScore W2616890438C134018914 @default.
• W2616890438 hasConceptScore W2616890438C134550120 @default.
• W2616890438 hasConceptScore W2616890438C2776156579 @default.
• W2616890438 hasConceptScore W2616890438C2776789170 @default.
• W2616890438 hasConceptScore W2616890438C2779134260 @default.
• W2616890438 hasConceptScore W2616890438C2779280383 @default.
• W2616890438 hasConceptScore W2616890438C31705614 @default.
• W2616890438 hasConceptScore W2616890438C36103677 @default.
• W2616890438 hasConceptScore W2616890438C502032728 @default.
• W2616890438 hasConceptScore W2616890438C555293320 @default.
• W2616890438 hasConceptScore W2616890438C556039675 @default.
• W2616890438 hasConceptScore W2616890438C71924100 @default.
• W2616890438 hasConceptScore W2616890438C98274493 @default.
• W2616890438 hasIssue "1" @default.

• next