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• W2616895005 abstract "Andrographis paniculata is a herbal plant in the Acanthaceae family with potential to treat diabetes and cardiovascular and asan antifertility agent. The purpose of this study was to determine the reversible antifertility effect of methanol extract A.paniculata on sperm quality and spermatogenesis. A total of 28 male Sprague Dawley rats were assigned into two groups;control group (K1) and treated group (K2) with 14 rats in each group. The treated group was force-fed with a dose of 800mg/kg for 14 days. On day 15, seven rats from each group were sacrificed. There was significant decrease (p<0.05) in spermcount, viability and sperm motility grade in K2 compared to K1, however, the percentage of normal sperm morphology inboth groups showed no difference. Histologically, the lumens of seminiferous tubule were seen less packed with sperm andthe Leydig cells were regressed. The damaged Sertoli cells were seen and spermatogenesis was also inhibited in K2. Thestudy was proceeded for another 14 days without treatment to determine the reversible effect of the extract. On day 29, theremainder seven rats from each group were sacrificed for the same parameter analysis. Data showed the sperm count, viabilityand the sperm motility grade in K2 increased significantly (p<0.05). The testes histology showed that normal spermatogenesis,seminiferous tubule filled with sperm and normal Leydig and Sertoli cells. It appeared that the methanol extract of A. paniculatahave an antifertility effect on sperm quality and possess spermatoxic feature in spermatogenesis activity and the effect wasreversible." @default.
• W2616895005 created "2017-06-05" @default.
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• W2616895005 date "2017-03-01" @default.
• W2616895005 modified "2023-09-23" @default.
• W2616895005 title "Reversible spermatoxic effect of Andrographis paniculata methanol extract in Sprague Dawley rats" @default.
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