FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2616944218> ?p ?o ?g. }

• W2616944218 endingPage "406" @default.
• W2616944218 startingPage "392" @default.
• W2616944218 abstract "Polysialic acid (PSA) is a large, negatively charged, linear homopolymer of alpha2-8-linked sialic acid residues. It is generated by two polysialyltransferases and attached to N- and/or O-linked glycans, and its main carrier is the neural cell adhesion molecule (NCAM). PSA controls the development and regeneration of the nervous system by enhancing cell migration, axon pathfinding, synaptic targeting, synaptic plasticity, by regulating the differentiation of progenitor cells and by modulating cell-cell and cell-matrix adhesions. In the adult, PSA plays a role in the immune system, and PSA mimetics promote functional recovery after nervous system injury. In search for novel small molecule mimetics of PSA that are applicable for therapy, we identified idarubicin, an antineoplastic anthracycline, and irinotecan, an antineoplastic agent of the topoisomerase I inhibitor class, as PSA mimetics using a competition enzyme-linked immunosorbent assay. Idarubicin and irinotecan compete with the PSA-mimicking peptide and colominic acid, the bacterial analog of PSA, for binding to the PSA-specific monoclonal antibody 735. Idarubicin and irinotecan stimulate neurite outgrowth and survival of cultured cerebellar neurons after oxidative stress via protein kinase C and Erk1/2 in a similar manner as colominic acid, whereas Fyn, casein kinase II and the phosphatase and tensin homolog are only involved in idarubicin and irinotecan-stimulated neurite outgrowth. These novel results show that the structure and function of PSA can be mimicked by the small organic compounds irinotecan and idarubicin which trigger the same signaling cascades as PSA, thus introducing the possibility of retargeting these drugs to treat nervous system injuries." @default.
• W2616944218 created "2017-06-05" @default.
• W2616944218 creator A5000407694 @default.
• W2616944218 creator A5004973809 @default.
• W2616944218 creator A5013006072 @default.
• W2616944218 creator A5015993199 @default.
• W2616944218 creator A5016916300 @default.
• W2616944218 creator A5045905555 @default.
• W2616944218 creator A5049765264 @default.
• W2616944218 creator A5051833391 @default.
• W2616944218 creator A5082265228 @default.
• W2616944218 date "2017-06-20" @default.
• W2616944218 modified "2023-10-15" @default.
• W2616944218 title "The polysialic acid mimetics idarubicin and irinotecan stimulate neuronal survival and neurite outgrowth and signal via protein kinase C" @default.
• W2616944218 cites W132683945 @default.
• W2616944218 cites W1488137693 @default.
• W2616944218 cites W1490814884 @default.
• W2616944218 cites W1498373535 @default.
• W2616944218 cites W1498735063 @default.
• W2616944218 cites W1510884166 @default.
• W2616944218 cites W1539927687 @default.
• W2616944218 cites W1717362450 @default.
• W2616944218 cites W1743663113 @default.
• W2616944218 cites W1931802909 @default.
• W2616944218 cites W1965842745 @default.
• W2616944218 cites W1966621020 @default.
• W2616944218 cites W1966724696 @default.
• W2616944218 cites W1978749842 @default.
• W2616944218 cites W1979343320 @default.
• W2616944218 cites W1985353690 @default.
• W2616944218 cites W1987438805 @default.
• W2616944218 cites W1987822504 @default.
• W2616944218 cites W1991160714 @default.
• W2616944218 cites W1993283480 @default.
• W2616944218 cites W1993875393 @default.
• W2616944218 cites W1999911226 @default.
• W2616944218 cites W2005932295 @default.
• W2616944218 cites W2006128826 @default.
• W2616944218 cites W2013631185 @default.
• W2616944218 cites W2019986705 @default.
• W2616944218 cites W2020715178 @default.
• W2616944218 cites W2026632890 @default.
• W2616944218 cites W2029503143 @default.
• W2616944218 cites W2031631096 @default.
• W2616944218 cites W2031790580 @default.
• W2616944218 cites W2036788942 @default.
• W2616944218 cites W2041422241 @default.
• W2616944218 cites W2042431388 @default.
• W2616944218 cites W2048129906 @default.
• W2616944218 cites W2051125361 @default.
• W2616944218 cites W2054271640 @default.
• W2616944218 cites W2055592286 @default.
• W2616944218 cites W2057790314 @default.
• W2616944218 cites W2064572902 @default.
• W2616944218 cites W2069221168 @default.
• W2616944218 cites W2070827711 @default.
• W2616944218 cites W2077247278 @default.
• W2616944218 cites W2077439657 @default.
• W2616944218 cites W2079010602 @default.
• W2616944218 cites W2086782135 @default.
• W2616944218 cites W2092122140 @default.
• W2616944218 cites W2094844863 @default.
• W2616944218 cites W2097371392 @default.
• W2616944218 cites W2123396714 @default.
• W2616944218 cites W2124170577 @default.
• W2616944218 cites W2126818728 @default.
• W2616944218 cites W2141046449 @default.
• W2616944218 cites W2150649688 @default.
• W2616944218 cites W2151069021 @default.
• W2616944218 cites W2151081587 @default.
• W2616944218 cites W2153613897 @default.
• W2616944218 cites W2156771487 @default.
• W2616944218 cites W2163669616 @default.
• W2616944218 cites W2165029000 @default.
• W2616944218 cites W2170758516 @default.
• W2616944218 cites W2206848459 @default.
• W2616944218 cites W2257876215 @default.
• W2616944218 cites W2273967916 @default.
• W2616944218 cites W2286272055 @default.
• W2616944218 cites W2291658560 @default.
• W2616944218 cites W2300505259 @default.
• W2616944218 cites W2319494661 @default.
• W2616944218 cites W2407324151 @default.
• W2616944218 cites W2466328987 @default.
• W2616944218 cites W4231432428 @default.
• W2616944218 doi "https://doi.org/10.1111/jnc.14076" @default.
• W2616944218 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5539918" @default.
• W2616944218 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28542923" @default.
• W2616944218 hasPublicationYear "2017" @default.
• W2616944218 type Work @default.
• W2616944218 sameAs 2616944218 @default.
• W2616944218 citedByCount "12" @default.
• W2616944218 countsByYear W26169442182018 @default.
• W2616944218 countsByYear W26169442182019 @default.
• W2616944218 countsByYear W26169442182020 @default.
• W2616944218 countsByYear W26169442182022 @default.
• W2616944218 countsByYear W26169442182023 @default.
• W2616944218 crossrefType "journal-article" @default.

• next