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- W2616951892 abstract "Described herein is a mechanism-based approach to develop a versatile C-H amidation protocol under IrIII catalysis. Reaction kinetics of a key C-N coupling step with acyl azide and 1,4,2-dioxazol-5-one led us to conclude that dioxazolones are much more efficient in mediating the formation of a carbon-nitrogen bond from an iridacyclic intermediate. Computational analysis revealed that the origin of higher reactivity is asynchronous decarboxylation motion, which may facilitate the formation of Ir-imido species. Importantly, stoichiometric reactivity was successfully translated into catalytic activity with a broad range of substrates (18 different types), many of which are regarded as challenging to functionalize. Application of the new method enables late-stage functionalization of drug molecules." @default.
- W2616951892 created "2017-06-05" @default.
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- W2616951892 creator A5049414933 @default.
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- W2616951892 date "2017-07-28" @default.
- W2616951892 modified "2023-10-03" @default.
- W2616951892 title "Mechanism-Driven Approach To Develop a Mild and Versatile C−H Amidation through Ir<sup>III</sup>Catalysis" @default.
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- W2616951892 doi "https://doi.org/10.1002/chem.201702397" @default.
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