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• W2616974080 abstract "Diabetes-induced muscle loss is associated with stimulated the muscle RING-finger protein 1 (MuRF1), a muscle specific E3 ubiquitin ligase. Elevated lipid metabolites impair myogenesis. Flavanol-rich lychee fruit extract (FRLFE) exhibited anti-diabetic and -obesity properties which would be an alternative approach for maintaining muscle homeostasis. PURPOSE: The underlying mechanisms of FRLFE on maintaining muscle homeostasis was studied in vivo and in vitro. METHODS: Dietary (10 wk) FRLFE supplementation (200 mg/kg diet) on the skeletal muscle size and transcription factors such as NF-κB and Foxo3a involved in regulation of MuRF1 were investigated in diabetic db/db mice (n=10/per group). The roles of FRLFE on cell cycle and senescent phenotype were investigated in palmitate-induced insulin resistance in C2C12 muscle cells. The statistical significance of the differences among the groups (P < 0.05) was determined by one-way ANOVA and following post hoc assessment by Student-Newman-Keuls Method. RESULTS: The average cross-sectional area was significantly increased by 1.6-fold after administration of FRLFE compared with non-treated db/db mice (420μm2). Prevention of muscle loss by FRLFE was associated with down regulation of MuRF1 mRNA expression (410% vs. 100%, p<0.05). Decreased NF-κB expression in the nuclear fraction was observed in FRLFE treated db/db mice compared with untreated mice (260% vs. 60%, p<0.05). At transcriptional level, FRLFE abated ceramide-induced MuRF1 promoter activity (200% vs. 100%, p<0.05). Restoration of SIRT1 expression (30% vs. 150%, p<0.05) prevented Foxo3a nuclear localization in FRLFE treated db/db mice. A strong β-galactosidase staining positive signal was observed in the palmitate-treated myoblasts. For cell cycle analysis, significantly increased proportion of cells in G2-phase by palmitate was observed compared with group without palmitate treatment (28.9% vs. 18.3%). Weak β-galactosidase staining positive signals in accordance with decreased proportion of cells in G2-phase (21.7%) were observed in FRLFE-treated myoblasts. CONCLUSION: The efficacy of FRLFE on preserving skeletal muscle mass and myogenic process indicates that FRLFE acts as an effective supplement for diabetes and/or obesity-induced muscle atrophy." @default.
• W2616974080 created "2017-06-05" @default.
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• W2616974080 date "2017-05-01" @default.
• W2616974080 modified "2023-09-25" @default.
• W2616974080 title "Flavanol-Rich Lychee Fruit Extract Prevents Diabetes-induced Muscle Loss And Palmitate-induced Myotube Loss" @default.
• W2616974080 doi "https://doi.org/10.1249/01.mss.0000519524.22220.79" @default.
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