Matches in SemOpenAlex for { <https://semopenalex.org/work/W2617003155> ?p ?o ?g. }
- W2617003155 endingPage "33" @default.
- W2617003155 startingPage "33" @default.
- W2617003155 abstract "Myeloperoxidase (MPO) belongs to the family of heme-containing peroxidases, produced mostly from polymorphonuclear neutrophils. The active enzyme (150 kDa) is the product of the MPO gene located on long arm of chromosome 17. The primary gene product undergoes several modifications, such as the removal of introns and signal peptides, and leads to the formation of enzymatically inactive glycosylated apoproMPO which complexes with chaperons, producing inactive proMPO by the insertion of a heme moiety. The active enzyme is a homodimer of heavy and light chain protomers. This enzyme is released into the extracellular fluid after oxidative stress and different inflammatory responses. Myeloperoxidase is the only type of peroxidase that uses H2O2 to oxidize several halides and pseudohalides to form different hypohalous acids. So, the antibacterial activities of MPO involve the production of reactive oxygen and reactive nitrogen species. Controlled MPO release at the site of infection is of prime importance for its efficient activities. Any uncontrolled degranulation exaggerates the inflammation and can also lead to tissue damage even in absence of inflammation. Several types of tissue injuries and the pathogenesis of several other major chronic diseases such as rheumatoid arthritis, cardiovascular diseases, liver diseases, diabetes, and cancer have been reported to be linked with MPO-derived oxidants. Thus, the enhanced level of MPO activity is one of the best diagnostic tools of inflammatory and oxidative stress biomarkers among these commonly-occurring diseases." @default.
- W2617003155 created "2017-06-05" @default.
- W2617003155 creator A5065898891 @default.
- W2617003155 creator A5082284202 @default.
- W2617003155 creator A5084401624 @default.
- W2617003155 date "2018-04-18" @default.
- W2617003155 modified "2023-10-10" @default.
- W2617003155 title "Myeloperoxidase as an Active Disease Biomarker: Recent Biochemical and Pathological Perspectives" @default.
- W2617003155 cites W1026060964 @default.
- W2617003155 cites W1456504179 @default.
- W2617003155 cites W1505149221 @default.
- W2617003155 cites W1506275008 @default.
- W2617003155 cites W1525107448 @default.
- W2617003155 cites W1532795681 @default.
- W2617003155 cites W1584766640 @default.
- W2617003155 cites W1600783018 @default.
- W2617003155 cites W1606963643 @default.
- W2617003155 cites W1638726768 @default.
- W2617003155 cites W1669011391 @default.
- W2617003155 cites W1772269777 @default.
- W2617003155 cites W1845299120 @default.
- W2617003155 cites W1914775755 @default.
- W2617003155 cites W1952870193 @default.
- W2617003155 cites W1963617522 @default.
- W2617003155 cites W1964949062 @default.
- W2617003155 cites W1970339106 @default.
- W2617003155 cites W1970443937 @default.
- W2617003155 cites W1970681355 @default.
- W2617003155 cites W1971435128 @default.
- W2617003155 cites W1971786132 @default.
- W2617003155 cites W1973018387 @default.
- W2617003155 cites W1975746081 @default.
- W2617003155 cites W1975972501 @default.
- W2617003155 cites W1976616659 @default.
- W2617003155 cites W1977102146 @default.
- W2617003155 cites W1977384147 @default.
- W2617003155 cites W1977796000 @default.
- W2617003155 cites W1978878743 @default.
- W2617003155 cites W1981356555 @default.
- W2617003155 cites W1985855906 @default.
- W2617003155 cites W1985997391 @default.
- W2617003155 cites W1986753163 @default.
- W2617003155 cites W1987587435 @default.
- W2617003155 cites W1988631382 @default.
- W2617003155 cites W1992887841 @default.
- W2617003155 cites W1994606929 @default.
- W2617003155 cites W1995006827 @default.
- W2617003155 cites W1995899440 @default.
- W2617003155 cites W1996854958 @default.
- W2617003155 cites W1997474235 @default.
- W2617003155 cites W1997517963 @default.
- W2617003155 cites W1999517476 @default.
- W2617003155 cites W2000155150 @default.
- W2617003155 cites W2001840006 @default.
- W2617003155 cites W2002771345 @default.
- W2617003155 cites W2006061640 @default.
- W2617003155 cites W2007187686 @default.
- W2617003155 cites W2007995316 @default.
- W2617003155 cites W2008370029 @default.
- W2617003155 cites W2010575607 @default.
- W2617003155 cites W2011239271 @default.
- W2617003155 cites W2011500110 @default.
- W2617003155 cites W2013204959 @default.
- W2617003155 cites W2013287270 @default.
- W2617003155 cites W2014225278 @default.
- W2617003155 cites W2015264794 @default.
- W2617003155 cites W2015591510 @default.
- W2617003155 cites W2016327540 @default.
- W2617003155 cites W2016627273 @default.
- W2617003155 cites W2018542299 @default.
- W2617003155 cites W2021213904 @default.
- W2617003155 cites W2021882325 @default.
- W2617003155 cites W2023020387 @default.
- W2617003155 cites W2023847300 @default.
- W2617003155 cites W2024170817 @default.
- W2617003155 cites W2026648244 @default.
- W2617003155 cites W2027946740 @default.
- W2617003155 cites W2028031080 @default.
- W2617003155 cites W2031576122 @default.
- W2617003155 cites W2033968078 @default.
- W2617003155 cites W2034367487 @default.
- W2617003155 cites W2035299293 @default.
- W2617003155 cites W2035626087 @default.
- W2617003155 cites W2036704125 @default.
- W2617003155 cites W2037826719 @default.
- W2617003155 cites W2040233646 @default.
- W2617003155 cites W2040252933 @default.
- W2617003155 cites W2041198388 @default.
- W2617003155 cites W2041475242 @default.
- W2617003155 cites W2043446682 @default.
- W2617003155 cites W2045532378 @default.
- W2617003155 cites W2047632582 @default.
- W2617003155 cites W2048533116 @default.
- W2617003155 cites W2050243594 @default.
- W2617003155 cites W2050669250 @default.
- W2617003155 cites W2050758464 @default.
- W2617003155 cites W2053142936 @default.
- W2617003155 cites W2053369310 @default.