FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2617032419> ?p ?o ?g. }

• W2617032419 endingPage "56" @default.
• W2617032419 startingPage "43" @default.
• W2617032419 abstract "A link between diabetes mellitus (DM) related islet amyloid polypeptide (IAPP) and Alzheimer's disease (AD) related amyloid-β (Aβ) has been suggested in epidemiological and clinical studies. In 2017, proof for existing interaction between type 2 DM and AD on a molecular level was provided based on research carried out in experimental animal models. We assessed aging-related neurodegenerative lesions, i.e., misfolded proteins, associated with dementia such as hyperphosphorylated τ (HPτ), Aβ, α-synuclein (αS), and phosphorylated transactive DNA binding protein 43 (pTDP43) seen in the brain and IAPP seen in the pancreas in subjects with and without DM applying immunohistochemical techniques. HPτ in the brain and IAPP in the pancreas were observed in most subjects. The prevalence and the extent of all misfolded proteins increased with age but this increase was not influenced by DM. Interestingly the extent of misfolded proteins in the brain was higher in non-diabetics when compared with diabetics in demented. A significant correlation was observed between HPτ, Aβ, αS, and pTDP43, whereas IAPP showed no association with HPτ, Aβ, and αS. In subjects with DM, the extent of pTDP43 in brain correlated with the extent of IAPP in pancreas. Thus, there is no evidence of a link between AD-related pathology and DM in humans, whereas an association was found between pTDP43 and IAPP in DM. TDP43 is ubiquitously expressed in all organs but whether TDP43 is phosphorylated in other organs in DM or whether the phosphorylation of TDP43 is influenced by glucose metabolism is yet unknown." @default.
• W2617032419 created "2017-06-05" @default.
• W2617032419 creator A5011419309 @default.
• W2617032419 creator A5037145306 @default.
• W2617032419 creator A5089275240 @default.
• W2617032419 date "2017-07-03" @default.
• W2617032419 modified "2023-09-24" @default.
• W2617032419 title "Transactive DNA Binding Protein 43 Rather Than Other Misfolded Proteins in the Brain is Associated with Islet Amyloid Polypeptide in Pancreas in Aged Subjects with Diabetes Mellitus" @default.
• W2617032419 cites W10948360 @default.
• W2617032419 cites W1106983225 @default.
• W2617032419 cites W1645350431 @default.
• W2617032419 cites W1837066325 @default.
• W2617032419 cites W1967443709 @default.
• W2617032419 cites W1967823816 @default.
• W2617032419 cites W1999062513 @default.
• W2617032419 cites W2003618511 @default.
• W2617032419 cites W2006797111 @default.
• W2617032419 cites W2012526287 @default.
• W2617032419 cites W2027177575 @default.
• W2617032419 cites W2028416698 @default.
• W2617032419 cites W2028713570 @default.
• W2617032419 cites W2036792490 @default.
• W2617032419 cites W2037915842 @default.
• W2617032419 cites W2038300433 @default.
• W2617032419 cites W2066881823 @default.
• W2617032419 cites W206978487 @default.
• W2617032419 cites W2073449985 @default.
• W2617032419 cites W2074249519 @default.
• W2617032419 cites W2079403467 @default.
• W2617032419 cites W2091265793 @default.
• W2617032419 cites W2093650784 @default.
• W2617032419 cites W2101841732 @default.
• W2617032419 cites W2102572922 @default.
• W2617032419 cites W2109241488 @default.
• W2617032419 cites W2126581925 @default.
• W2617032419 cites W2128228199 @default.
• W2617032419 cites W2138638156 @default.
• W2617032419 cites W2143461767 @default.
• W2617032419 cites W2146343703 @default.
• W2617032419 cites W2157617823 @default.
• W2617032419 cites W2163314359 @default.
• W2617032419 cites W2171236187 @default.
• W2617032419 cites W2209022283 @default.
• W2617032419 cites W2260379945 @default.
• W2617032419 cites W2287966587 @default.
• W2617032419 cites W2290336843 @default.
• W2617032419 cites W2292782286 @default.
• W2617032419 cites W2297272001 @default.
• W2617032419 cites W2322177510 @default.
• W2617032419 cites W2461151446 @default.
• W2617032419 cites W2463189234 @default.
• W2617032419 cites W2469121291 @default.
• W2617032419 cites W2509224801 @default.
• W2617032419 cites W2514506319 @default.
• W2617032419 cites W2548167872 @default.
• W2617032419 cites W2552319314 @default.
• W2617032419 cites W2557663540 @default.
• W2617032419 cites W2560590017 @default.
• W2617032419 cites W2915384989 @default.
• W2617032419 cites W842083477 @default.
• W2617032419 cites W2575403535 @default.
• W2617032419 doi "https://doi.org/10.3233/jad-170192" @default.
• W2617032419 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5502839" @default.
• W2617032419 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28582864" @default.
• W2617032419 hasPublicationYear "2017" @default.
• W2617032419 type Work @default.
• W2617032419 sameAs 2617032419 @default.
• W2617032419 citedByCount "7" @default.
• W2617032419 countsByYear W26170324192018 @default.
• W2617032419 countsByYear W26170324192019 @default.
• W2617032419 countsByYear W26170324192020 @default.
• W2617032419 countsByYear W26170324192021 @default.
• W2617032419 countsByYear W26170324192023 @default.
• W2617032419 crossrefType "journal-article" @default.
• W2617032419 hasAuthorship W2617032419A5011419309 @default.
• W2617032419 hasAuthorship W2617032419A5037145306 @default.
• W2617032419 hasAuthorship W2617032419A5089275240 @default.
• W2617032419 hasBestOaLocation W26170324191 @default.
• W2617032419 hasConcept C11960822 @default.
• W2617032419 hasConcept C126322002 @default.
• W2617032419 hasConcept C134018914 @default.
• W2617032419 hasConcept C142724271 @default.
• W2617032419 hasConcept C165220095 @default.
• W2617032419 hasConcept C2777633098 @default.
• W2617032419 hasConcept C2778764654 @default.
• W2617032419 hasConcept C2779134260 @default.
• W2617032419 hasConcept C2779483572 @default.
• W2617032419 hasConcept C55493867 @default.
• W2617032419 hasConcept C555293320 @default.
• W2617032419 hasConcept C71924100 @default.
• W2617032419 hasConcept C86803240 @default.
• W2617032419 hasConceptScore W2617032419C11960822 @default.
• W2617032419 hasConceptScore W2617032419C126322002 @default.
• W2617032419 hasConceptScore W2617032419C134018914 @default.
• W2617032419 hasConceptScore W2617032419C142724271 @default.
• W2617032419 hasConceptScore W2617032419C165220095 @default.
• W2617032419 hasConceptScore W2617032419C2777633098 @default.
• W2617032419 hasConceptScore W2617032419C2778764654 @default.

• next