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• W2617058515 endingPage "56790" @default.
• W2617058515 startingPage "56780" @default.
• W2617058515 abstract "The CASP8 -652 6N insertion/deletion (I/D) polymorphism reduces expression of caspase 8. We conducted a meta-analysis to clarify the relationship between this polymorphism and cancer risk. Eligible articles were retrieved from PubMed, EMBASE, CNKI, and WANFANG databases through February 2017. A total of 33 articles with 49 studies, including 33,494 cases and 36,397 controls, were analyzed. We found that the CASP8 -652 6N ins/del polymorphism was associated with decreased overall cancer risk in five genetic models [DD vs. II: odds ratio (OR)=0.76, 95% confidence interval (CI)=0.69-0.84, ID vs. II: OR=0.87, 95% CI=0.83-0.92, DD vs.OR=0.82, 95% CI=0.75-0.89, ID/DD vs. II: OR=0.85, 95% CI=0.80-0.90, and D vs. I: OR=0.87, 95% CI=0.83-0.91]. Stratified analyses showed that the polymorphism was associated with decreased risk of colorectal, breast, esophageal, renal cell, lung, cervical, bladder, gastric, and other cancers. Overall cancer risk was reduced in Asian and Caucasian patients, both hospital- and population-based studies, and both high and low quality studies. Our results highlight the role of the CASP8 -652 6N ins/del polymorphism in decreasing cancer risk. Further studies with large-cohort populations, especially for specific cancer types and ethnic groups, are needed to confirm our findings." @default.
• W2617058515 created "2017-06-05" @default.
• W2617058515 creator A5014544666 @default.
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• W2617058515 date "2017-05-25" @default.
• W2617058515 modified "2023-09-27" @default.
• W2617058515 title "<i>CASP8</i>-652 6N insertion/deletion polymorphism and overall cancer risk: evidence from 49 studies" @default.
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• W2617058515 doi "https://doi.org/10.18632/oncotarget.18187" @default.
• W2617058515 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5593601" @default.
• W2617058515 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28915630" @default.
• W2617058515 hasPublicationYear "2017" @default.
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