Matches in SemOpenAlex for { <https://semopenalex.org/work/W2617074166> ?p ?o ?g. }
- W2617074166 endingPage "e0177474" @default.
- W2617074166 startingPage "e0177474" @default.
- W2617074166 abstract "Objective Atrial fibrillation (AF) is frequently detected after ischemic stroke for the first time, and brain regions involved in autonomic control have been suspected to trigger AF. We examined whether specific brain regions are associated with newly detected AF after ischemic stroke. Methods Patients with acute cerebral infarctions on diffusion-weighted magnetic resonance imaging were included in this lesion mapping study. Lesions were mapped and modeled voxelwise using Bayesian Spatial Generalised Linear Mixed Modeling to determine differences in infarct locations between stroke patients with new AF, without AF and with AF already known before the stroke. Results 582 patients were included (median age 68 years; 63.2% male). AF was present in 109/582 patients [(18.7%); new AF: 39/109 (35.8%), known AF: 70/109 (64.2%)]. AF patients had larger infarct volumes than patients without AF (mean: 29.7 ± 45.8 ml vs. 15.2 ± 35.1 ml; p<0.001). Lesions in AF patients accumulated in the right central middle cerebral artery territory. Increasing stroke size predicted progressive cortical but not pontine and thalamic involvement. Patients with new AF had more frequently lesions in the right insula compared to patients without AF when stroke size was not accounted for, but no specific brain region was more frequently involved after adjustment for infarct volume. Controlled for stroke size, left parietal involvement was less likely for patients with new AF than for those without AF or with known AF. Conclusions In the search for brain areas potentially triggering cardiac arrhythmias infarct size should be accounted for. After controlling for infarct size, there is currently no evidence that ischemic stroke lesions of specific brain areas are associated with new AF compared to patients without AF. This challenges the neurogenic hypothesis of AF according to which a relevant proportion of new AF is triggered by ischemic brain lesions of particular locations." @default.
- W2617074166 created "2017-06-05" @default.
- W2617074166 creator A5004852507 @default.
- W2617074166 creator A5010331921 @default.
- W2617074166 creator A5039490283 @default.
- W2617074166 creator A5056453682 @default.
- W2617074166 creator A5061643035 @default.
- W2617074166 creator A5070898918 @default.
- W2617074166 creator A5087668487 @default.
- W2617074166 date "2017-05-24" @default.
- W2617074166 modified "2023-10-17" @default.
- W2617074166 title "Voxelwise distribution of acute ischemic stroke lesions in patients with newly diagnosed atrial fibrillation: Trigger of arrhythmia or only target of embolism?" @default.
- W2617074166 cites W1966413587 @default.
- W2617074166 cites W1970319849 @default.
- W2617074166 cites W1971316923 @default.
- W2617074166 cites W1976954310 @default.
- W2617074166 cites W1983444259 @default.
- W2617074166 cites W2002220726 @default.
- W2617074166 cites W2006096283 @default.
- W2617074166 cites W2006799924 @default.
- W2617074166 cites W2008236598 @default.
- W2617074166 cites W2009664264 @default.
- W2617074166 cites W2010550566 @default.
- W2617074166 cites W2025684441 @default.
- W2617074166 cites W2043914183 @default.
- W2617074166 cites W2050265501 @default.
- W2617074166 cites W2052644075 @default.
- W2617074166 cites W2053999497 @default.
- W2617074166 cites W2058161128 @default.
- W2617074166 cites W2065028337 @default.
- W2617074166 cites W2071881327 @default.
- W2617074166 cites W2074959430 @default.
- W2617074166 cites W2087961547 @default.
- W2617074166 cites W2098541838 @default.
- W2617074166 cites W2098973055 @default.
- W2617074166 cites W2102731214 @default.
- W2617074166 cites W2110678376 @default.
- W2617074166 cites W2111966088 @default.
- W2617074166 cites W2127038877 @default.
- W2617074166 cites W2127270213 @default.
- W2617074166 cites W2127309075 @default.
- W2617074166 cites W2127732410 @default.
- W2617074166 cites W2129906781 @default.
- W2617074166 cites W2148726987 @default.
- W2617074166 cites W2153857579 @default.
- W2617074166 cites W2163274894 @default.
- W2617074166 cites W2164956985 @default.
- W2617074166 cites W2229896252 @default.
- W2617074166 cites W2275737843 @default.
- W2617074166 cites W2307176359 @default.
- W2617074166 cites W2560670476 @default.
- W2617074166 cites W3106059482 @default.
- W2617074166 doi "https://doi.org/10.1371/journal.pone.0177474" @default.
- W2617074166 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5443524" @default.
- W2617074166 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28542605" @default.
- W2617074166 hasPublicationYear "2017" @default.
- W2617074166 type Work @default.
- W2617074166 sameAs 2617074166 @default.
- W2617074166 citedByCount "12" @default.
- W2617074166 countsByYear W26170741662017 @default.
- W2617074166 countsByYear W26170741662018 @default.
- W2617074166 countsByYear W26170741662019 @default.
- W2617074166 countsByYear W26170741662020 @default.
- W2617074166 countsByYear W26170741662021 @default.
- W2617074166 countsByYear W26170741662022 @default.
- W2617074166 countsByYear W26170741662023 @default.
- W2617074166 crossrefType "journal-article" @default.
- W2617074166 hasAuthorship W2617074166A5004852507 @default.
- W2617074166 hasAuthorship W2617074166A5010331921 @default.
- W2617074166 hasAuthorship W2617074166A5039490283 @default.
- W2617074166 hasAuthorship W2617074166A5056453682 @default.
- W2617074166 hasAuthorship W2617074166A5061643035 @default.
- W2617074166 hasAuthorship W2617074166A5070898918 @default.
- W2617074166 hasAuthorship W2617074166A5087668487 @default.
- W2617074166 hasBestOaLocation W26170741661 @default.
- W2617074166 hasConcept C126322002 @default.
- W2617074166 hasConcept C126838900 @default.
- W2617074166 hasConcept C127413603 @default.
- W2617074166 hasConcept C142724271 @default.
- W2617074166 hasConcept C143409427 @default.
- W2617074166 hasConcept C164705383 @default.
- W2617074166 hasConcept C2775841333 @default.
- W2617074166 hasConcept C2777185221 @default.
- W2617074166 hasConcept C2777798775 @default.
- W2617074166 hasConcept C2779161974 @default.
- W2617074166 hasConcept C2780645631 @default.
- W2617074166 hasConcept C2781156865 @default.
- W2617074166 hasConcept C500558357 @default.
- W2617074166 hasConcept C541997718 @default.
- W2617074166 hasConcept C71924100 @default.
- W2617074166 hasConcept C78519656 @default.
- W2617074166 hasConceptScore W2617074166C126322002 @default.
- W2617074166 hasConceptScore W2617074166C126838900 @default.
- W2617074166 hasConceptScore W2617074166C127413603 @default.
- W2617074166 hasConceptScore W2617074166C142724271 @default.
- W2617074166 hasConceptScore W2617074166C143409427 @default.
- W2617074166 hasConceptScore W2617074166C164705383 @default.
- W2617074166 hasConceptScore W2617074166C2775841333 @default.