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• W2617089932 abstract "A non-diaryl quinoline scaffold 6,7-dihydropyrazolo[1,5-a]pyrazin-4-one was identified by screening of diverse set of compounds against M. smegmatis ATP synthase. Herein, we disclose our efforts to develop the structure activity relationship against Mycobacterium tuberculosis (Mtb.H37Rv strain) around the identified hit 1. A scaffold hopping approach was used to identify compounds 14a, 14b and 24a with improved activity against MTb.H37Rv." @default.
• W2617089932 created "2017-06-05" @default.
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• W2617089932 date "2017-08-01" @default.
• W2617089932 modified "2023-10-13" @default.
• W2617089932 title "Identification and synthesis of novel inhibitors of mycobacterium ATP synthase" @default.
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• W2617089932 doi "https://doi.org/10.1016/j.bmcl.2017.05.081" @default.
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