Matches in SemOpenAlex for { <https://semopenalex.org/work/W2617096708> ?p ?o ?g. }
- W2617096708 endingPage "e2812" @default.
- W2617096708 startingPage "e2812" @default.
- W2617096708 abstract "Abstract Histones are intra-nuclear cationic proteins that are present in all eukaryotic cells and are highly conserved across species. Within the nucleus, they provide structural stability to chromatin and regulate gene expression. Histone may be released into the extracellular space in three forms: freely, as a DNA-bound nucleosome or as part of neutrophil extracellular traps, and all three can be detected in serum after significant cellular death such as sepsis, trauma, ischaemia/reperfusion injury and autoimmune disease. Once in the extracellular space, histones act as damage-associated molecular pattern proteins, activating the immune system and causing further cytotoxicity. They interact with Toll-like receptors (TLRs), complement and the phospholipids of cell membranes inducing endothelial and epithelial cytotoxicity, TLR2/TLR4/TLR9 activation and pro-inflammatory cytokine/chemokine release via MyD88, NFκB and NLRP3 inflammasome-dependent pathways. Drugs that block the release of histone, neutralise circulating histone or block histone signal transduction provide significant protection from mortality in animal models of acute organ injury but warrant further research to inform future clinical applications." @default.
- W2617096708 created "2017-06-05" @default.
- W2617096708 creator A5021064727 @default.
- W2617096708 creator A5022693579 @default.
- W2617096708 creator A5052590910 @default.
- W2617096708 creator A5080765126 @default.
- W2617096708 date "2017-05-25" @default.
- W2617096708 modified "2023-10-06" @default.
- W2617096708 title "The role of extracellular histone in organ injury" @default.
- W2617096708 cites W107941992 @default.
- W2617096708 cites W1464666752 @default.
- W2617096708 cites W1496811300 @default.
- W2617096708 cites W1499906668 @default.
- W2617096708 cites W1600560134 @default.
- W2617096708 cites W161836838 @default.
- W2617096708 cites W1720411342 @default.
- W2617096708 cites W1938477866 @default.
- W2617096708 cites W1967014670 @default.
- W2617096708 cites W1969691479 @default.
- W2617096708 cites W1971799714 @default.
- W2617096708 cites W1978508787 @default.
- W2617096708 cites W1979952618 @default.
- W2617096708 cites W1984805653 @default.
- W2617096708 cites W1984848905 @default.
- W2617096708 cites W1986282241 @default.
- W2617096708 cites W1995482231 @default.
- W2617096708 cites W1995586746 @default.
- W2617096708 cites W1999408698 @default.
- W2617096708 cites W1999478182 @default.
- W2617096708 cites W2000987923 @default.
- W2617096708 cites W2001546520 @default.
- W2617096708 cites W2002698073 @default.
- W2617096708 cites W2004465286 @default.
- W2617096708 cites W2005130936 @default.
- W2617096708 cites W2006003949 @default.
- W2617096708 cites W2006679777 @default.
- W2617096708 cites W2008024105 @default.
- W2617096708 cites W2008906374 @default.
- W2617096708 cites W2009036858 @default.
- W2617096708 cites W2014678245 @default.
- W2617096708 cites W2017785279 @default.
- W2617096708 cites W2021912241 @default.
- W2617096708 cites W2025102161 @default.
- W2617096708 cites W2028797773 @default.
- W2617096708 cites W2029497579 @default.
- W2617096708 cites W2034340491 @default.
- W2617096708 cites W2034808365 @default.
- W2617096708 cites W2035515342 @default.
- W2617096708 cites W2035601236 @default.
- W2617096708 cites W2043756611 @default.
- W2617096708 cites W2044384913 @default.
- W2617096708 cites W2045819100 @default.
- W2617096708 cites W2046934643 @default.
- W2617096708 cites W2050449334 @default.
- W2617096708 cites W2051384995 @default.
- W2617096708 cites W2054376629 @default.
- W2617096708 cites W2055132644 @default.
- W2617096708 cites W2055215728 @default.
- W2617096708 cites W2056924043 @default.
- W2617096708 cites W2059944604 @default.
- W2617096708 cites W2061213644 @default.
- W2617096708 cites W2068854215 @default.
- W2617096708 cites W2073625832 @default.
- W2617096708 cites W2076122670 @default.
- W2617096708 cites W2080586887 @default.
- W2617096708 cites W2080869236 @default.
- W2617096708 cites W2081278295 @default.
- W2617096708 cites W2083363029 @default.
- W2617096708 cites W2085522739 @default.
- W2617096708 cites W2086632246 @default.
- W2617096708 cites W2087647367 @default.
- W2617096708 cites W2091512988 @default.
- W2617096708 cites W2095361792 @default.
- W2617096708 cites W2098103685 @default.
- W2617096708 cites W2098920407 @default.
- W2617096708 cites W2100158915 @default.
- W2617096708 cites W2101674426 @default.
- W2617096708 cites W2102359149 @default.
- W2617096708 cites W2102831728 @default.
- W2617096708 cites W2104934425 @default.
- W2617096708 cites W2109178826 @default.
- W2617096708 cites W2110751735 @default.
- W2617096708 cites W2112211760 @default.
- W2617096708 cites W2112313575 @default.
- W2617096708 cites W2114100604 @default.
- W2617096708 cites W2118125488 @default.
- W2617096708 cites W2120563714 @default.
- W2617096708 cites W2122020125 @default.
- W2617096708 cites W2125382661 @default.
- W2617096708 cites W2130154369 @default.
- W2617096708 cites W2130989367 @default.
- W2617096708 cites W2133353550 @default.
- W2617096708 cites W2134046896 @default.
- W2617096708 cites W2136623765 @default.
- W2617096708 cites W2143152020 @default.
- W2617096708 cites W2143461874 @default.
- W2617096708 cites W2144792857 @default.
- W2617096708 cites W2152818840 @default.