Matches in SemOpenAlex for { <https://semopenalex.org/work/W2617103674> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2617103674 abstract "The 12/15 lipoxygenase (LOX) enzyme catalyzes oxygenation of fatty acids to form lipid mediators leading to non-resolving inflammation. However, how 12/15LOX interacts with PUFA (polyunsaturated fatty acids) in post-myocardial infarction (MI) cardiac healing is unclear. Here we assessed the role of 12/15LOX in post-MI cardiac remodeling in a PUFA (10% w/w, 22 Kcal) enriched environment. C57BL/6J wild-type (WT) and 12/15LOX null (12/15LOX –/– ) male mice of 8-12-weeks age were fed PUFA-enriched diet for 1 month and subjected to permanent coronary artery ligation. Post-MI mice were monitored for day (d)1 or d5 along with standard diet (SD)-fed MI controls. No-MI surgery mice served as d0 controls. 12/15LOX and PUFA+12/15LOX -/- mice reduced infarcted wall thinning with decreased lung edema index at d5 post-MI (all p<0.05) despite comparable infarct area (49-52%). PUFA+WT and 12/15LOX -/- mice showed improved ejection fraction with reduced left ventricle (LV) hypertrophy index than SD+WT at d5 post-MI (p<0.05). The neutrophil density was decreased in both PUFA+WT and 12/15LOX -/- mice at d1 post-MI (P<0.05). The neutrophil clearance was rapid in 12/15LOX -/- alone and PUFA+12/15LOX -/- mice, with increases in expression of formyl peptide receptor 2 at d5 post-MI. The macrophage density was decreased in PUFA+WT and 12/15LOX -/- mice compared with their respective SD+WT control at d5 post-MI. PUFA+12/15LOX -/- mice displayed an increased expression of ccl2 (all p<0.05) in the infarct area. 12/15LOX deletion stimulated 5-LOX and heme oxygenase-1 in PUFA+12/15LOX -/- mice with increased levels of 9-and 13-hydroxyoctadecadienoic acid indicating improved resolution of inflammation at d5 post-MI. The PUFA+12/15LOX -/- mice displayed higher expression of proresolving macrophages ym-1, mrc-1 and arg-1 compared with SD+12/15LOX -/- mice at d5 post-MI (all p<0.05). Further, 12/15LOX -/- mice with or without PUFA showed reduced collagen deposition at d5 post-MI compared to SD+WT. In conclusion, deletion of 12/15LOX and short-term PUFA exposure attenuated cardiac remodeling via shortening the pro-inflammatory window, thus leading to an improved resolution of inflammation and LV function post-MI." @default.
- W2617103674 created "2017-06-05" @default.
- W2617103674 creator A5007568139 @default.
- W2617103674 creator A5011003263 @default.
- W2617103674 creator A5013428111 @default.
- W2617103674 creator A5047616595 @default.
- W2617103674 creator A5047758341 @default.
- W2617103674 creator A5069347117 @default.
- W2617103674 date "2015-07-17" @default.
- W2617103674 modified "2023-09-22" @default.
- W2617103674 title "Abstract 213: Deletion of 12/15 Lipoxygenase and Fatty Acids Interaction Alters Leukocyte Kinetics Leading to Improved Healing Following Myocardial Infarction" @default.
- W2617103674 doi "https://doi.org/10.1161/res.117.suppl_1.213" @default.
- W2617103674 hasPublicationYear "2015" @default.
- W2617103674 type Work @default.
- W2617103674 sameAs 2617103674 @default.
- W2617103674 citedByCount "0" @default.
- W2617103674 crossrefType "journal-article" @default.
- W2617103674 hasAuthorship W2617103674A5007568139 @default.
- W2617103674 hasAuthorship W2617103674A5011003263 @default.
- W2617103674 hasAuthorship W2617103674A5013428111 @default.
- W2617103674 hasAuthorship W2617103674A5047616595 @default.
- W2617103674 hasAuthorship W2617103674A5047758341 @default.
- W2617103674 hasAuthorship W2617103674A5069347117 @default.
- W2617103674 hasConcept C126322002 @default.
- W2617103674 hasConcept C134018914 @default.
- W2617103674 hasConcept C181199279 @default.
- W2617103674 hasConcept C185592680 @default.
- W2617103674 hasConcept C19038510 @default.
- W2617103674 hasConcept C2776914184 @default.
- W2617103674 hasConcept C2778198053 @default.
- W2617103674 hasConcept C2778921608 @default.
- W2617103674 hasConcept C2780857362 @default.
- W2617103674 hasConcept C500558357 @default.
- W2617103674 hasConcept C543025807 @default.
- W2617103674 hasConcept C55493867 @default.
- W2617103674 hasConcept C71924100 @default.
- W2617103674 hasConcept C78085059 @default.
- W2617103674 hasConceptScore W2617103674C126322002 @default.
- W2617103674 hasConceptScore W2617103674C134018914 @default.
- W2617103674 hasConceptScore W2617103674C181199279 @default.
- W2617103674 hasConceptScore W2617103674C185592680 @default.
- W2617103674 hasConceptScore W2617103674C19038510 @default.
- W2617103674 hasConceptScore W2617103674C2776914184 @default.
- W2617103674 hasConceptScore W2617103674C2778198053 @default.
- W2617103674 hasConceptScore W2617103674C2778921608 @default.
- W2617103674 hasConceptScore W2617103674C2780857362 @default.
- W2617103674 hasConceptScore W2617103674C500558357 @default.
- W2617103674 hasConceptScore W2617103674C543025807 @default.
- W2617103674 hasConceptScore W2617103674C55493867 @default.
- W2617103674 hasConceptScore W2617103674C71924100 @default.
- W2617103674 hasConceptScore W2617103674C78085059 @default.
- W2617103674 hasIssue "suppl_1" @default.
- W2617103674 hasLocation W26171036741 @default.
- W2617103674 hasOpenAccess W2617103674 @default.
- W2617103674 hasPrimaryLocation W26171036741 @default.
- W2617103674 hasRelatedWork W1552047714 @default.
- W2617103674 hasRelatedWork W1982455349 @default.
- W2617103674 hasRelatedWork W2000339401 @default.
- W2617103674 hasRelatedWork W2003442392 @default.
- W2617103674 hasRelatedWork W2006452441 @default.
- W2617103674 hasRelatedWork W2149275975 @default.
- W2617103674 hasRelatedWork W2198064013 @default.
- W2617103674 hasRelatedWork W2271631843 @default.
- W2617103674 hasRelatedWork W2364551809 @default.
- W2617103674 hasRelatedWork W2382455758 @default.
- W2617103674 hasRelatedWork W2400051404 @default.
- W2617103674 hasRelatedWork W2615739902 @default.
- W2617103674 hasRelatedWork W2790938638 @default.
- W2617103674 hasRelatedWork W2805185084 @default.
- W2617103674 hasRelatedWork W2892525729 @default.
- W2617103674 hasRelatedWork W2982282004 @default.
- W2617103674 hasRelatedWork W3023815470 @default.
- W2617103674 hasRelatedWork W3189228403 @default.
- W2617103674 hasRelatedWork W3198444249 @default.
- W2617103674 hasRelatedWork W1764952922 @default.
- W2617103674 hasVolume "117" @default.
- W2617103674 isParatext "false" @default.
- W2617103674 isRetracted "false" @default.
- W2617103674 magId "2617103674" @default.
- W2617103674 workType "article" @default.