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- W2617201056 endingPage "97670" @default.
- W2617201056 startingPage "97657" @default.
- W2617201056 abstract "// Zimin Pan 1 and Xing Xie 1 1 Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, People’s Republic of China Correspondence to: Xing Xie, email: xie.xing@yahoo.com Keywords: BRCA, ovarian cancer, pathogenesis, chemotherapy, targeted therapy Received: February 14, 2017 Accepted: April 28, 2017 Published: May 30, 2017 ABSTRACT BRCA genes are important for the integrity and stability of genetic material and play key roles in repairing DNA breaks via high fidelity homologous recombination. BRCA mutations are known to predispose carriers to gynecological malignancies, accounting for a majority of hereditary OC cases. Known to be lethal, OC is difficult to detect and control. Testing for BRCA mutations is a key step in the risk assessment, prognosis, treatment and prevention of OC and current clinical guidelines recommend BRCA mutation testing for all OCs of epithelial origin. Studies have established that ovarian tumors harboring BRCA mutations have distinct molecular and histo-pathological features that can be exploited for effective, targeted treatment. Deficiencies in DNA repair pathways that arise as a result of BRCA mutations make them hypersensitive to DNA-damaging treatments such as platinum chemotherapy and PARP inhibitors. Different combinations of treatment regimens which have the potential to greatly improve prognosis and disease outcomes are currently being evaluated. However, the issue of developing resistance to these treatments remains unresolved. This review emphasizes unique features of BRCA mutated OC and outlines the lay of the land in terms of diagnosis and treatment, while aiming to unravel the challenges that are part of its management." @default.
- W2617201056 created "2017-06-05" @default.
- W2617201056 creator A5017899711 @default.
- W2617201056 creator A5060805738 @default.
- W2617201056 date "2017-05-30" @default.
- W2617201056 modified "2023-10-16" @default.
- W2617201056 title "BRCA mutations in the manifestation and treatment of ovarian cancer" @default.
- W2617201056 cites W121553317 @default.
- W2617201056 cites W1484356204 @default.
- W2617201056 cites W1485595432 @default.
- W2617201056 cites W1588157222 @default.
- W2617201056 cites W1894955529 @default.
- W2617201056 cites W1926715094 @default.
- W2617201056 cites W1951483173 @default.
- W2617201056 cites W1961928411 @default.
- W2617201056 cites W1971954823 @default.
- W2617201056 cites W1973268287 @default.
- W2617201056 cites W1973421344 @default.
- W2617201056 cites W1976564360 @default.
- W2617201056 cites W1988224215 @default.
- W2617201056 cites W1988515793 @default.
- W2617201056 cites W1994563300 @default.
- W2617201056 cites W2009007206 @default.
- W2617201056 cites W2013344385 @default.
- W2617201056 cites W2015360671 @default.
- W2617201056 cites W2025460005 @default.
- W2617201056 cites W2029997311 @default.
- W2617201056 cites W2030093162 @default.
- W2617201056 cites W2033816200 @default.
- W2617201056 cites W2036546668 @default.
- W2617201056 cites W2038793520 @default.
- W2617201056 cites W2040686951 @default.
- W2617201056 cites W2042227848 @default.
- W2617201056 cites W2044132177 @default.
- W2617201056 cites W2045733577 @default.
- W2617201056 cites W2046056066 @default.
- W2617201056 cites W2046814345 @default.
- W2617201056 cites W2052234547 @default.
- W2617201056 cites W2052716289 @default.
- W2617201056 cites W2058064521 @default.
- W2617201056 cites W2059000312 @default.
- W2617201056 cites W2061635845 @default.
- W2617201056 cites W2064695479 @default.
- W2617201056 cites W2065849886 @default.
- W2617201056 cites W2067117419 @default.
- W2617201056 cites W2070369494 @default.
- W2617201056 cites W2079388655 @default.
- W2617201056 cites W2081401566 @default.
- W2617201056 cites W2085076399 @default.
- W2617201056 cites W2085491990 @default.
- W2617201056 cites W2086757750 @default.
- W2617201056 cites W2086833406 @default.
- W2617201056 cites W2087025655 @default.
- W2617201056 cites W2090740451 @default.
- W2617201056 cites W2090968329 @default.
- W2617201056 cites W2096253955 @default.
- W2617201056 cites W2098024955 @default.
- W2617201056 cites W2103455702 @default.
- W2617201056 cites W2106157865 @default.
- W2617201056 cites W2109584956 @default.
- W2617201056 cites W2110017381 @default.
- W2617201056 cites W2110790489 @default.
- W2617201056 cites W2116128552 @default.
- W2617201056 cites W2116186978 @default.
- W2617201056 cites W2117964602 @default.
- W2617201056 cites W2118498634 @default.
- W2617201056 cites W2120806256 @default.
- W2617201056 cites W2123696077 @default.
- W2617201056 cites W2130078242 @default.
- W2617201056 cites W2130344626 @default.
- W2617201056 cites W2132854918 @default.
- W2617201056 cites W2132927361 @default.
- W2617201056 cites W2135525536 @default.
- W2617201056 cites W2137538783 @default.
- W2617201056 cites W2144707486 @default.
- W2617201056 cites W2146373785 @default.
- W2617201056 cites W2147071985 @default.
- W2617201056 cites W2150111967 @default.
- W2617201056 cites W2151509048 @default.
- W2617201056 cites W2152217620 @default.
- W2617201056 cites W2153966196 @default.
- W2617201056 cites W2154175915 @default.
- W2617201056 cites W2156205902 @default.
- W2617201056 cites W2160466424 @default.
- W2617201056 cites W2163446307 @default.
- W2617201056 cites W2168880218 @default.
- W2617201056 cites W2168893449 @default.
- W2617201056 cites W2169678941 @default.
- W2617201056 cites W2169983032 @default.
- W2617201056 cites W2171658624 @default.
- W2617201056 cites W2213445629 @default.
- W2617201056 cites W2235523093 @default.
- W2617201056 cites W2259408084 @default.
- W2617201056 cites W2287706376 @default.
- W2617201056 cites W2293618284 @default.
- W2617201056 cites W2295085830 @default.
- W2617201056 cites W2305810750 @default.
- W2617201056 cites W2308659819 @default.