FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2617233684> ?p ?o ?g. }

• W2617233684 endingPage "1459" @default.
• W2617233684 startingPage "1453" @default.
• W2617233684 abstract "We discuss the hypothesis that ZEB1-Wnt-p300 signaling integrates epithelial to mesenchymal transition (EMT) and resistance to histone deacetylase inhibitors (HDACis) in colorectal cancer (CRC) cells. The HDACi butyrate, derived from dietary fiber, has been linked to CRC prevention, and other HDACis have been proposed as therapeutic agents against CRC. We have previously discussed that resistance to butyrate likely contributes to colonic carcinogenesis, and we have demonstrated that butyrate resistance leads to cross-resistance to cancer therapeutic HDACis. Deregulated Wnt signaling is the major initiating event in most CRC cases. One mechanism whereby butyrate and other HDACis exert their anti-CRC effects is via Wnt signaling hyperactivation, which promotes CRC cell apoptosis. The histone acetylases (HATs) CBP and p300 are mediators of Wnt transcriptional activity, and play divergent roles in the downstream consequences of Wnt signaling. CBP-mediated Wnt signaling is associated with cell proliferation and stem cell maintenance; whereas, p300-mediated Wnt activity is associated with differentiation. We have found that CBP and p300 differentially affect the ability of butyrate to influence Wnt signaling, apoptosis, and proliferation. ZEB1 is a Wnt signaling-targeted gene, whose product is a transcription factor expressed at the invasive front of carcinomas where it promotes malignant progression and EMT. ZEB1 is typically a transcriptional repressor; however, when associated with p300, ZEB1 enhances transcription. These changes in ZEB1 activity likely affect the cancer cell phenotype. ZEB1 has been shown to promote resistance to chemotherapeutic agents, and expression of ZEB1 is upregulated in butyrate-resistant CRC cells that lack p300 expression. Since the expression of ZEB1 correlates with poor outcomes in cancer, ZEB represents a relevant therapeutic target. Here we propose that targeting the signaling network established by ZEB1, Wnt signaling, and p300 signaling can reverse HDACi resistance and inhibit EMT." @default.
• W2617233684 created "2017-06-05" @default.
• W2617233684 creator A5054453491 @default.
• W2617233684 creator A5054487082 @default.
• W2617233684 date "2017-01-01" @default.
• W2617233684 modified "2023-10-15" @default.
• W2617233684 title "ZEB1 Mediates Drug Resistance and EMT in p300-Deficient CRC" @default.
• W2617233684 cites W1021332480 @default.
• W2617233684 cites W1499915332 @default.
• W2617233684 cites W1579963067 @default.
• W2617233684 cites W1593004859 @default.
• W2617233684 cites W1830269738 @default.
• W2617233684 cites W1896007356 @default.
• W2617233684 cites W1928298256 @default.
• W2617233684 cites W1931140155 @default.
• W2617233684 cites W1964485346 @default.
• W2617233684 cites W1967137553 @default.
• W2617233684 cites W1967243795 @default.
• W2617233684 cites W1968251679 @default.
• W2617233684 cites W1973959916 @default.
• W2617233684 cites W1975881786 @default.
• W2617233684 cites W1976287566 @default.
• W2617233684 cites W1982057613 @default.
• W2617233684 cites W1984430627 @default.
• W2617233684 cites W1985733585 @default.
• W2617233684 cites W1989215255 @default.
• W2617233684 cites W1995046740 @default.
• W2617233684 cites W1995133050 @default.
• W2617233684 cites W2009993892 @default.
• W2617233684 cites W2024585236 @default.
• W2617233684 cites W2028593825 @default.
• W2617233684 cites W2028693181 @default.
• W2617233684 cites W2029784055 @default.
• W2617233684 cites W2029857102 @default.
• W2617233684 cites W2033660315 @default.
• W2617233684 cites W2037422913 @default.
• W2617233684 cites W2037583144 @default.
• W2617233684 cites W2038833190 @default.
• W2617233684 cites W2039165130 @default.
• W2617233684 cites W2039661491 @default.
• W2617233684 cites W2044383852 @default.
• W2617233684 cites W2050089891 @default.
• W2617233684 cites W2050414776 @default.
• W2617233684 cites W2053985534 @default.
• W2617233684 cites W2055310509 @default.
• W2617233684 cites W2056628299 @default.
• W2617233684 cites W2056801328 @default.
• W2617233684 cites W2064027874 @default.
• W2617233684 cites W2076118448 @default.
• W2617233684 cites W2077893873 @default.
• W2617233684 cites W2078351836 @default.
• W2617233684 cites W2080598921 @default.
• W2617233684 cites W2081758458 @default.
• W2617233684 cites W2090636859 @default.
• W2617233684 cites W2093423091 @default.
• W2617233684 cites W2093965955 @default.
• W2617233684 cites W2105599008 @default.
• W2617233684 cites W2113779553 @default.
• W2617233684 cites W2115001053 @default.
• W2617233684 cites W2118195139 @default.
• W2617233684 cites W2121389240 @default.
• W2617233684 cites W2121982452 @default.
• W2617233684 cites W2125436596 @default.
• W2617233684 cites W2131331729 @default.
• W2617233684 cites W2133450689 @default.
• W2617233684 cites W2135232490 @default.
• W2617233684 cites W2135865691 @default.
• W2617233684 cites W2138732842 @default.
• W2617233684 cites W2139477740 @default.
• W2617233684 cites W2144509527 @default.
• W2617233684 cites W2146167376 @default.
• W2617233684 cites W2147807172 @default.
• W2617233684 cites W2149908207 @default.
• W2617233684 cites W2150359108 @default.
• W2617233684 cites W2150909248 @default.
• W2617233684 cites W2155131748 @default.
• W2617233684 cites W2158579203 @default.
• W2617233684 cites W2161080156 @default.
• W2617233684 cites W2162438863 @default.
• W2617233684 cites W2165739143 @default.
• W2617233684 cites W2166295460 @default.
• W2617233684 cites W2168787308 @default.
• W2617233684 cites W2177850607 @default.
• W2617233684 cites W2204695746 @default.
• W2617233684 cites W2222701722 @default.
• W2617233684 cites W2237880968 @default.
• W2617233684 cites W2259200740 @default.
• W2617233684 cites W2325723327 @default.
• W2617233684 cites W2429625728 @default.
• W2617233684 cites W2475324019 @default.
• W2617233684 cites W2559932550 @default.
• W2617233684 cites W2564989217 @default.
• W2617233684 cites W92073110 @default.
• W2617233684 doi "https://doi.org/10.7150/jca.18762" @default.
• W2617233684 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5479251" @default.
• W2617233684 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28638460" @default.
• W2617233684 hasPublicationYear "2017" @default.
• W2617233684 type Work @default.

• next