FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2617237563> ?p ?o ?g. }

• W2617237563 endingPage "1171" @default.
• W2617237563 startingPage "1159" @default.
• W2617237563 abstract "Summary Objective Seizures in mesial temporal lobe epilepsy ( MTLE ) associated with hippocampal sclerosis are thought to develop with various latency intervals after an initial transient brain insult. To study seizure dynamics after an initial transient precipitating insult in a systematic fashion, we utilized continuous video–electroencephalography (EEG) monitoring after the induction of status epilepticus ( SE ) in a mouse MTLE model. Methods Continuous 24/7 video/telemetric hippocampal EEG recordings in the systemic pilocarpine MTLE mouse model. Results After SE , we observed emerging seizures interfering with the circadian EEG rhythms. The physiologic circadian EEG pattern of mice was transiently suppressed for 2.9 (mean) ± (SEM) 0.5 days after SE . This period was accompanied predominately by nonconvulsive seizure activity, followed by convulsive seizures at later stages. After the circadian rhythm was restored, spontaneous generalized seizures occurred mainly in a clustered manner in a narrow time window between 4 and 7 p.m. (light cycle 7 a.m./7 p.m.). Moreover, we demonstrate that depth‐electrode implantation surgery transiently disturbs the physiologic EEG circadian cycle; variation of the time point of SE induction after electrode insertion surgery revealed a substantial impact on the epilepsy phenotype, which was more severe when SE occurred after postsurgical reappearance of EEG circadian cycling. Significance These data have several experimental and pathophysiologic implications. The impact of depth‐electrode surgery on the phenotype has to be tightly controlled. In mice monitored after pilocarpine‐induced SE , the “epileptogenesis” period is characterized by the dynamics of epileptiform activity toward behavioral recurrent seizure patterns. The striking clustering of spontaneous seizures at the transition from sleep to activity stages of mice has to be taken into account for future studies on the model. Improving our understanding of the molecular mechanisms that determine the circadian dynamics of seizure threshold remains an intriguing task for the future." @default.
• W2617237563 created "2017-06-05" @default.
• W2617237563 creator A5003615920 @default.
• W2617237563 creator A5004859175 @default.
• W2617237563 creator A5017476278 @default.
• W2617237563 creator A5027294480 @default.
• W2617237563 creator A5043187819 @default.
• W2617237563 creator A5072488640 @default.
• W2617237563 date "2017-05-24" @default.
• W2617237563 modified "2023-10-17" @default.
• W2617237563 title "Circadian clustering of spontaneous epileptic seizures emerges after pilocarpine-induced status epilepticus" @default.
• W2617237563 cites W1553429955 @default.
• W2617237563 cites W1896206937 @default.
• W2617237563 cites W1965911702 @default.
• W2617237563 cites W1965953789 @default.
• W2617237563 cites W1967634043 @default.
• W2617237563 cites W1970202218 @default.
• W2617237563 cites W1978326730 @default.
• W2617237563 cites W1978582068 @default.
• W2617237563 cites W1984050978 @default.
• W2617237563 cites W1984310623 @default.
• W2617237563 cites W1987408294 @default.
• W2617237563 cites W1991147561 @default.
• W2617237563 cites W1995536650 @default.
• W2617237563 cites W2007054480 @default.
• W2617237563 cites W2008966677 @default.
• W2617237563 cites W2010425177 @default.
• W2617237563 cites W2010460856 @default.
• W2617237563 cites W2013055611 @default.
• W2617237563 cites W2014995849 @default.
• W2617237563 cites W2015513895 @default.
• W2617237563 cites W2031575360 @default.
• W2617237563 cites W2031616221 @default.
• W2617237563 cites W2032166622 @default.
• W2617237563 cites W2034299256 @default.
• W2617237563 cites W2042050853 @default.
• W2617237563 cites W2052032553 @default.
• W2617237563 cites W2062870268 @default.
• W2617237563 cites W2063810190 @default.
• W2617237563 cites W2074710570 @default.
• W2617237563 cites W2078428957 @default.
• W2617237563 cites W2079239821 @default.
• W2617237563 cites W2085116094 @default.
• W2617237563 cites W2087519172 @default.
• W2617237563 cites W2089746292 @default.
• W2617237563 cites W2093238337 @default.
• W2617237563 cites W2127725502 @default.
• W2617237563 cites W2127817146 @default.
• W2617237563 cites W2138234506 @default.
• W2617237563 cites W2139125704 @default.
• W2617237563 cites W2156511434 @default.
• W2617237563 cites W2264658168 @default.
• W2617237563 cites W2288238997 @default.
• W2617237563 doi "https://doi.org/10.1111/epi.13795" @default.
• W2617237563 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28542864" @default.
• W2617237563 hasPublicationYear "2017" @default.
• W2617237563 type Work @default.
• W2617237563 sameAs 2617237563 @default.
• W2617237563 citedByCount "42" @default.
• W2617237563 countsByYear W26172375632017 @default.
• W2617237563 countsByYear W26172375632018 @default.
• W2617237563 countsByYear W26172375632019 @default.
• W2617237563 countsByYear W26172375632020 @default.
• W2617237563 countsByYear W26172375632021 @default.
• W2617237563 countsByYear W26172375632022 @default.
• W2617237563 countsByYear W26172375632023 @default.
• W2617237563 crossrefType "journal-article" @default.
• W2617237563 hasAuthorship W2617237563A5003615920 @default.
• W2617237563 hasAuthorship W2617237563A5004859175 @default.
• W2617237563 hasAuthorship W2617237563A5017476278 @default.
• W2617237563 hasAuthorship W2617237563A5027294480 @default.
• W2617237563 hasAuthorship W2617237563A5043187819 @default.
• W2617237563 hasAuthorship W2617237563A5072488640 @default.
• W2617237563 hasBestOaLocation W26172375631 @default.
• W2617237563 hasConcept C121446783 @default.
• W2617237563 hasConcept C148762608 @default.
• W2617237563 hasConcept C15744967 @default.
• W2617237563 hasConcept C169760540 @default.
• W2617237563 hasConcept C17755696 @default.
• W2617237563 hasConcept C2777204577 @default.
• W2617237563 hasConcept C2777341932 @default.
• W2617237563 hasConcept C2777597344 @default.
• W2617237563 hasConcept C2778186239 @default.
• W2617237563 hasConcept C2780803581 @default.
• W2617237563 hasConcept C2781099131 @default.
• W2617237563 hasConcept C42219234 @default.
• W2617237563 hasConcept C522805319 @default.
• W2617237563 hasConcept C57236427 @default.
• W2617237563 hasConcept C71924100 @default.
• W2617237563 hasConceptScore W2617237563C121446783 @default.
• W2617237563 hasConceptScore W2617237563C148762608 @default.
• W2617237563 hasConceptScore W2617237563C15744967 @default.
• W2617237563 hasConceptScore W2617237563C169760540 @default.
• W2617237563 hasConceptScore W2617237563C17755696 @default.
• W2617237563 hasConceptScore W2617237563C2777204577 @default.
• W2617237563 hasConceptScore W2617237563C2777341932 @default.
• W2617237563 hasConceptScore W2617237563C2777597344 @default.
• W2617237563 hasConceptScore W2617237563C2778186239 @default.

• next